A5068577663- Calcium signaling and nucleotide metabolism
- Abdominal vascular conditions and treatments
- Sirtuins and Resveratrol in Medicine
- Vascular anomalies and interventions
- PARP inhibition in cancer therapy
- Aortic aneurysm repair treatments
- Renal and Vascular Pathologies
- Aortic Disease and Treatment Approaches
- RNA Interference and Gene Delivery
- Adenosine and Purinergic Signaling
- Thin-Film Transistor Technologies
- Coronary Artery Anomalies
- Gallbladder and Bile Duct Disorders
- Infectious Aortic and Vascular Conditions
- Nutrition, Genetics, and Disease
- Vascular Malformations Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Kawasaki Disease and Coronary Complications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Abdominal Surgery and Complications
- Intracranial Aneurysms: Treatment and Complications
- Ion Channels and Receptors
- Cardiac, Anesthesia and Surgical Outcomes
- Metabolomics and Mass Spectrometry Studies
- Cancer Treatment and Pharmacology
Mayo Clinic
2013-2024
Mayo Clinic in Arizona
2014-2024
WinnMed
2018-2023
Mayo Clinic in Florida
2022-2023
Current studies on the age-related development of metabolic dysfunction and frailty are each day in more evidence. It is known, as aging progresses, nicotinamide adenine dinucleotide (NAD+) levels decrease an expected physiological process. Recent have shown that a reduction NAD+ key factor for age-associated decline. Increased vivo results activation pro-longevity health span-related factors. Also, it improves several parameters aging, including muscle function, exercise capacity, glucose...
CD38 is a multifunctional enzyme involved in calcium signaling and Nicotinamide Adenine Dinucleotide (NAD+) metabolism. Through its major activity, the hydrolysis of NAD+, helps maintain appropriate levels this molecule for all NAD+-dependent metabolic processes to occur. Due current advances studies relating NAD+ decline development multiple age-related conditions diseases, gained importance both basic science clinical settings. The discovery strategies modulate function and, possibly,...
Maturational failure of dialysis arteriovenous fistulas (AVFs) not uncommonly occurs and is considerable timely importance. Our prior studies demonstrate that senescence, a phenotypic process promotes vascular other diseases, in the murine AVF. In present study, we examined whether senescence also rat AVF model effect compounds inhibit or accelerate senescence.
Steatosis is the most important prognostic histologic feature in setting of liver procurement. The currently utilized diagnostic methods, including gross evaluation and frozen section examination, have shortcomings. Novel techniques that offer advantages over current tools could be significant practical utility. aim this study to evaluate accuracy surface color spectrophotometry quantitative assessment steatosis a murine model fatty liver. C57BL/6 mice were divided into control group...
Aortic aneurysms are classified as complex based on their extent and involvement of side branches. Complex aortic include arch, thoracoabdominal, juxtarenal suprarenal aneurysms. Open surgical repair carries high morbidity mortality beyond large tertiary care centers. During the last decade, numerous technological advances have allowed incorporation branches using hybrid total endovascular techniques. Fenestrated branched endografts been widely applied to treat patients with aneurysm...
In mammals, nicotinamide (NAM) is the primary NAD precursor available in circulation, a signaling molecule, and for methyl-nicotinamide (M-NAM) synthesis. However, our knowledge about how body regulates tissue NAM levels still limited. Here we demonstrate that dietary vitamin B 3 partially plasma NAM-derived metabolites, but not their levels. We found de novo synthesis from tryptophan contributes to NAM, likely by providing substrates NAD-degrading enzymes. also mainly generated endogenous...