A5044135482- Calcium signaling and nucleotide metabolism
- Blood properties and coagulation
- Muscle Physiology and Disorders
- Neuroscience and Neuropharmacology Research
- Adenosine and Purinergic Signaling
- Histone Deacetylase Inhibitors Research
- Preterm Birth and Chorioamnionitis
- Neurotransmitter Receptor Influence on Behavior
- PARP inhibition in cancer therapy
- TGF-β signaling in diseases
- Muscle metabolism and nutrition
- Nutrition and Health in Aging
- Biomedical Ethics and Regulation
- Ion Channels and Receptors
- Neonatal and Maternal Infections
- Sirtuins and Resveratrol in Medicine
- Cytomegalovirus and herpesvirus research
- S100 Proteins and Annexins
- Exercise and Physiological Responses
- Frailty in Older Adults
- Air Quality and Health Impacts
- FOXO transcription factor regulation
- Pluripotent Stem Cells Research
- NF-κB Signaling Pathways
- Angiogenesis and VEGF in Cancer
Pennsylvania State University
2010-2023
Manchester Royal Infirmary
2023
Mayo Clinic in Arizona
2020-2023
Mayo Clinic
2017-2022
University of Michigan
2013-2020
WinnMed
2017-2019
Tisch Cancer Institute
2018
Tisch Hospital
2018
Rutgers, The State University of New Jersey
2000-2004
University of North Carolina at Chapel Hill
2000
Tissue nicotinamide adenine dinucleotide (NAD+) decline has been implicated in aging. We have recently identified CD38 as a central regulator involved tissue NAD+ during the aging process. is an ecto-enzyme highly expressed endothelial and inflammatory cells. To date, mechanisms that regulate expression tissues characterized by presence of senescent cells not completely understood. Cellular senescence described hallmark process these are known to secrete several factors including cytokines...
The neurotoxic actions of methamphetamine (METH) may be mediated in part by reactive oxygen species (ROS). Methamphetamine administration leads to increases ROS formation and lipid peroxidation rodent brain; however, the extent which proteins modified or whether affected brain regions exhibit similar elevations protein oxidative markers have not been investigated. In this study we measured concentrations TBARs, carbonyls monoamines various mouse at 4 h 24 after last four injections METH (10...
Abstract: [ 3 H]Dihydrotetrabenazine ([ H]DTBZ), a specific ligand for the vesicular monoamine transporter (VMAT2), has been used to characterize integrity of monoaminergic nerve terminals in experimental animals and humans. The purpose present studies was compare loss VMAT2 binding with other neurochemical markers dopamine (DA) mice treated neurotoxic doses methamphetamine (METH) or MPTP. Profound decreases (≥70%) DA content, tyrosine hydroxylase activity,...
Pregnant women are uniquely susceptible to adverse effects of air pollution exposure due vulnerabilities and health consequences during pregnancy (e.g., hypertensive disorders [HDP]) compared the general population. Because Clean Air Act (CAA) creates a duty protect at‐risk groups, regulatory assessment populations has both policy scientific foundations. Previously, pregnant have not been specially protected in establishing margin safety for ozone particulate matter (PM) standards. Due...
Significant differences exist in the sensitivity of mice and rats to neurotoxicity 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) that cannot be explained by exposure or uptake 1-methyl-4-phenylpyridinium (MPP(+)) into dopamine (DA) neurons. MPP(+) is also a substrate for brain vesicular monoamine transporter (VMAT2), sequestration synaptic vesicles may one mechanism protection against toxicity. A greater DA neurons versus could explain lower vulnerability rat To test this hypothesis,...
Group B Streptococcus (GBS) is a leading cause of neonatal morbidity and mortality. We tested the hypothesis that choriodecidua plays role in GBS-stimulated human beta defensin(HBD)-2 increases amnion cells through secreted factor choriodecidual origin. Human epithelial were treated with GBS-conditioned medium, live GBS, lipoteichoic acid (LTA), or lipopolysaccharide (LPS), without IL-1 inhibitors. Choriodecidual tissue punches released IL-1α IL-1β response to GBS this medium significantly...
Abstract Background Muscle wasting is a debilitating co‐morbidity affecting most advanced cancer patients. Alongside enhanced muscle catabolism, defects in repair/regeneration contribute to cancer‐associated wasting. Among the factors implicated suppression of regeneration are cytokines that interfere with myogenic signal transduction pathways. Less understood how other cancer/wasting‐associated cues, such as metabolites, dysfunction. This study investigates metabolite succinate affects...
We synthesized a variant, recombinant fibrinogen modeled after the heterozygous dysfibrinogen Vlissingen/Frankfurt IV, deletion of two residues, γAsn-319 and γAsp-320, located within high affinity calcium-binding pocket. Turbidity studies showed no evidence fibrin polymerization, although size exclusion chromatography, transmission electron microscopy, dynamic light scattering small aggregates. These aggregates did not resemble normal protofibrils nor they clot. Fibrinopeptide A release was...
IGF binding protein (IGFBP)-3 is an important regulator of mammary epithelial cell (MEC) growth and can enhance the ability both IGF-I epidermal factor ligands such as TGFalpha to stimulate MEC proliferation. Here we investigate role phosphatidylinositol-3 kinase (PI3K) MAPK pathways in regulation IGFBP-3 expression by bovine MECs. Both factors stimulated DNA synthesis, although was stronger mitogen. also mRNA levels. rapid, transient activation Akt that maximal at 5 min diminished 15 min....
Transforming growth factor β1 (TGFβ1) expression is elevated by tumor promoters in the mouse skin, but its role promotion has not been well defined. To investigate this, we have compared TGFβ1+/+ and +/− mice a two-stage skin chemical carcinogenesis protocol. Surprisingly, TGFβ1+/− had fewer number incidence of benign papillomas, reduced epidermal cell proliferation TGFβ1 nuclear p-Smad2 localization response to promoter 12- O -tetradecanoylphorbol 13-acetate (TPA) with mice. Maximal TPA...
Background: More than 80% of patients with advanced cancer develop weight loss. Because preclinical data suggest poly (ADP-ribose) polymerase (PARP) inhibitors can treat this loss, study was undertaken to explore the PARP inhibitor veliparib for indication. Objective: The current analyze prospectively gathered on in inhibitors. Design/Setting: relied a previously published, conducted phase 1 single institution trial that combined and topotecan (NCT01012817) as antineoplastic therapy...
Fibrinogen Otsu I:A γ Asn319,Asp320 deletion dysfibrinogen identified in an asymptomatic pregnant woman -
Abstract Group B streptococcus (GBS) infection is a significant public health concern associated with adverse pregnancy complications and increased neonatal mortality morbidity. However, the mechanisms underlying impact of GBS on fetal membrane, first line defense against pathogens, are not fully understood. Here, we propose that induces senescence inflammatory factors (IL-6 IL-8) in membrane through interleukin-1 (IL-1). Utilizing existing transcriptomic data GBS-exposed human showed...
e12594 Background: Obesity and weight gain are significant concerns for breast cancer survivors. at diagnosis of is an established negative prognostic factor post-diagnosis may increase risk recurrence. Studies suggest that decreased dietary fat intake loss after decrease Various interventions such as modification, physical activity, individualized counseling cognitive behavioral therapy, have been studied in order to identify strategies Methods: We enrolled obese women who diagnosed treated...
Weaving together biological, anthropological, and medical perspectives on breasts, Williams explores their susceptibility to environmental toxicants.