A5055153306- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Effects and risks of endocrine disrupting chemicals
- Per- and polyfluoroalkyl substances research
- Neonatal and Maternal Infections
- Mesenchymal stem cell research
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Preterm Birth and Chorioamnionitis
- Sperm and Testicular Function
- Pluripotent Stem Cells Research
- Immune cells in cancer
- Reproductive Biology and Fertility
- Pregnancy and Medication Impact
- Intergenerational Family Dynamics and Caregiving
- Gestational Diabetes Research and Management
- Fatty Acid Research and Health
- RNA and protein synthesis mechanisms
- RNA regulation and disease
- Immune Response and Inflammation
- Toxic Organic Pollutants Impact
- Veterinary Medicine and Surgery
- Hair Growth and Disorders
- Selenium in Biological Systems
- Peripheral Nerve Disorders
University of Michigan–Ann Arbor
2017-2024
University of Washington
2012-2023
Ann Arbor Center for Independent Living
2020
University of Southampton
2015
Hawaii Pacific University
2015
Tulane University
2008-2010
Granta Design (United Kingdom)
2002
Human mesenchymal stem cells (hMSCs) from bone marrow are regarded as putative osteoblast progenitors in vivo and differentiate into osteoblasts vitro. Positive signaling by the canonical wingless (Wnt) pathway is critical for differentiation of MSCs osteoblasts. In contrast, activation peroxisome proliferator-activated receptor-γ (PPARγ)-mediated results adipogenesis. We therefore compared effect glycogen-synthetase-kinase-3β (GSK3β) inhibitors PPARγ on osteogenesis hMSCs. Both compounds...
Current research has focused primarily on how hate works in groups or its theoretical nature. This study replicates previous findings (Aumer-Ryan & Hatfield, 2007) that is felt towards intimate others people we spend considerable time with. Ninety-eight participants filled out a survey concerning themselves, the they love and hate. Participants also about motivations Results demonstrate saw considerably differently than those love, themselves. Additionally, this provides empirical...
Trichloroethylene (TCE) is an industrial solvent and a common environmental contaminant. Reactive metabolites of TCE disrupt placental cell functions important for pregnancy health.
The eukaryotic translation initiation factor eIF2B is a multi-subunit complex with crucial role in the regulation of global protein synthesis cell. comprises five subunits, termed α through ε order increasing size, arranged as heterodecamer two copies each subunit. Regulation co-stoichiometric expression subunits for proper function and cells. We have investigated control stoichiometric complexes mutual stabilization subunits. Our data show that stable catalytic eIF2Bε subunit human cells...
Streptococcus agalactiae (group B streptococcus [GBS]) infection in pregnant women is the leading cause of infectious neonatal morbidity and mortality United States. Although inflammation during has been associated with preterm birth, contribution GBS to birth less certain. Moreover, early mechanisms by which interacts gestational tissue affect adverse pregnancy outcomes are poorly understood. We hypothesized that short-term inoculation activates pathways related premature human...
Per- and polyfluoroalkyl substances (PFAS) are fluorinated chemicals linked to adverse pregnancy birth outcomes. However, the underlying mechanisms, specifically their effects on maternal inflammatory processes, not well characterized.
Trichloroethylene (TCE) is a widespread environmental contaminant following decades of use as an industrial solvent, improper disposal, and remediation challenges. Consequently, TCE exposure continues to constitute risk human health. Despite epidemiological evidence associating with adverse birth outcomes, the effects its metabolite S-(1, 2-dichlorovinyl)-L-cysteine (DCVC) on placenta remain undetermined. Flexible efficient macronutrient energy metabolism pathway utilization essential for...
The endocrine basis of reproductive failure in red fox vixens was examined over two breeding seasons a total 11 animals.Weekly blood samples were assayed for progesterone, prolactin, LH and cortisol.Vaginal smears taken every 2 days the oestrous period indicated that all had mated.Vixens successfully gave birth to litter cubs demonstrated significantly higher plasma progesterone prolactin concentrations but lower cortisol than did females ovulated, then failed whelp.There no significant...
Lowest observable adverse effects level (LOAEL) is a standard point-of-departure dose in toxicology. However, first (FOAEL) was recently reported and used, this study, as one criterion to detect mutagenic stimulus live imager. Fluorescence ubiquitinated cell cycle indicator (FUCCI) embryonic stem cells (ESC) are green the S-G2-M phase of not G1-phase. Standard media change here mild stress that delays G1-phase increases 2.5- 5-fold. Since mild, rapidly number, but higher stresses...
Abstract Background Apolipoprotein E (ApoE) is a molecular scavenger in the blood and brain. Aberrant function of molecule causes formation protein lipid deposits or "plaques" that characterize Alzheimer's disease (AD) atherosclerosis. There are three human isoforms ApoE designated ε2, ε3, ε4. Each isoform differentially affects structure thus development disease. Homozygosity for ε4 associated with atherosclerosis whereas ε2 ε3 tend to be protective. Furthermore, form may cause forms...
OPS 21: Methodological progress in chemicals health effects research, Room 210, Floor 2, August 26, 2019, 4:30 PM - 5:30 Background: In epidemiologic failure to account for a toxicant's impact on spontaneous abortion (SA) can bias toxicant-birth outcome associations. We lack comprehensive understanding of high-risk SA chemicals, as many events occur before women are aware their pregnancy. Our goal was test overlap with SA, based toxicogenomic responses. Methods: used reference (MeSH:...
In addition to providing a physical compartment for gestation, the fetal membranes (FM) are an active immunological barrier that provides defense against pathogenic microorganisms ascend gravid reproductive tract. Pathogenic infection of gestational tissues (FM and placenta) is leading known cause preterm birth. Some environmental toxicants decrease capacity organisms mount immune pathogens. For example, immunosuppressive effects widespread contaminant trichloroethylene (TCE) documented lung...