A5026469055- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Toxic Organic Pollutants Impact
- Aldose Reductase and Taurine
- Heme Oxygenase-1 and Carbon Monoxide
- Carcinogens and Genotoxicity Assessment
- Mesenchymal stem cell research
- Genomics, phytochemicals, and oxidative stress
- Reproductive System and Pregnancy
- Chemical Reactions and Isotopes
- Per- and polyfluoroalkyl substances research
- Acute Lymphoblastic Leukemia research
- Molecular Biology Techniques and Applications
- Phagocytosis and Immune Regulation
- Sulfur Compounds in Biology
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Neonatal Respiratory Health Research
- Effects and risks of endocrine disrupting chemicals
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Prenatal Substance Exposure Effects
- Galectins and Cancer Biology
- Glutathione Transferases and Polymorphisms
- Amino Acid Enzymes and Metabolism
- Microbial bioremediation and biosurfactants
Translational Therapeutics (United States)
2022-2023
University of Pennsylvania
2022-2023
University of Michigan
2020-2023
Ann Arbor Center for Independent Living
2020
University of California, San Francisco
2014
Normal tissue architecture is disrupted following injury, as resident cells become damaged and immune are recruited to the site of injury. While injury inflammation critical remodeling, inability resolve this response can lead destructive complications chronic inflammation. In pancreas, acinar exocrine compartment respond by transiently adopting characteristics progenitor present during embryonic development. This process de-differentiation creates a window where mature stable cell gains...
Trichloroethylene (TCE) is an industrial solvent and a common environmental contaminant. Reactive metabolites of TCE disrupt placental cell functions important for pregnancy health.
1-Nitropyrene (1-NP) is a constituent of diesel exhaust and classified as group 2A probable human carcinogen. The metabolic activation 1-NP by nitroreduction generates electrophiles that can covalently bind DNA to form mutations contribute cancer causation. NADPH-dependent P450 oxidoreductase (POR), xanthine oxidase (XO), aldehyde (AOX), NAD(P)H/quinone 1 (NQO1) may catalyze nitroreduction. We recently found recombinant aldo-keto reductases (AKRs) 1C1–1C3 NQO1 AKR1C1–1C3 are genes induced...
1-Nitropyrene (1-NP) and 1,8-dinitropyrene (1,8-DNP) are diesel exhaust constituents classified by the International Agency for Research on Cancer as probable (Group 2A) or possible 2B) human carcinogens. These nitroarenes undergo metabolic activation nitroreduction to result in formation of DNA adducts. Human aldo–keto reductases (AKRs) 1C1-1C3 catalyze 3-nitrobenzanthrone (3-nitro-7H-benz[de]anthracen-7-one, 3-NBA), but extent AKR contribution toward additional nitroarenes, including 1-NP...
Hematopoietic stem cells are that differentiate into all blood cell types. Although the placenta secretes hormones, proteins and other factors important for maternal fetal health, cross-talk between placental hematopoietic is poorly understood. Moreover, toxicant impacts on placental-hematopoietic communication understudied. The goals of this study were to determine if secreted from alter transcriptomic responses in monoethylhexyl phthalate (MEHP), bioactive metabolite pollutant diethylhexyl...
Syncytialization, the fusion of cytotrophoblasts into an epithelial barrier that constitutes maternal–fetal interface, is a crucial event placentation. This process characterized by distinct changes to amino acid and energy metabolism. A metabolite industrial solvent trichloroethylene (TCE), S-(1,2-dichlorovinyl)-l-cysteine (DCVC), modifies metabolism abundance in HTR-8/SVneo extravillous trophoblasts. In current study, we investigated DCVC-induced acids during forskolin-stimulated...