Purpose: To investigate the course of inflammatory and angiogenic cytokines in aqueous humor patients with persistent/recurrent neovascular age-related macular degeneration (nAMD) under ranibizumab monotherapy (IVM) or plus dexamethasone combination treatment. Methods: In this 12-month prospective study, 40 eyes nAMD were treated either IVM combined treatment intravitreal implant (IVC). Patients group following an "as needed" regimen; IVC received a at baseline re-treated ranibizumab. At...

To investigate the influence of intravitreal dexamethasone implant on inflammatory and angiogenic cytokine levels in aqueous patients with retinal vein occlusion (RVO).Forty eyes 40 consecutive macular oedema (ME) due to branch central (BRVO/CRVO) were treated an (Ozurdex® ) at baseline evaluated until month 6. Retreatment was performed case recurrent ME earliest 4 months after treatment. Aqueous humour samples taken baseline, 1, 3, 6 time each retreatment. Concentrations 29 different...

Purpose: The purpose of this study is to compare the ability spectral domain optical coherence tomography angiography (SD-OCTA) and indocyanine green (ICGA) detect measure lesion area in patients with type 1 2 choroidal neovascularization (CNV). Methods: Types neovascular AMD (nAMD) were included prospective observational case series. ETDRS best-corrected visual acuity (BCVA), ophthalmic examination funduscopy, OCTA (AngioVue), fluorescein (FA), ICGA, OCT (Spectralis) performed. CNV...

Abstract Purpose Proliferative vitreoretinopathy (PVR) is a complication of retinal detachment which requires multiple vitreoretinal surgical interventions and frequent use oil endotamponade. In this study, we conducted an in-depth analysis complications associated with the heavy silicone in management inferior PVR. Methods A retrospective cohort study 20 eyes that underwent vitrectomy for PVR (Densiron 68) between March 2021 October 2022 at Oxford Eye Hospital. Complications were classified...

Background/Objectives: The aim of this paper was to evaluate the safety surgical intervention using anesthesia and ophthalmological parameters in pediatric strabismus patients. design involved retrospective case series. Methods: setting Department Ophthalmology, Medical University Vienna, Austria. Participants: In total, 208 children aged 0–18 years who underwent surgery due exotropia or esotropia between 2013 2020 were included. Main outcomes measures: Information regarding duration...

Purpose: To evaluate the evolution of surgical methods over a 7-year period in patients with primary rhegmatogenous retinal detachment (RRD) and its relation to functional outcome intra- postoperative complications.Methods: This prospective observational study included 628 RRD who underwent repair between January 2009 December 2015. The main measures were type procedure ((scleral buckle (SB), pars plana vitrectomy (PPV), combination SB PPV or cryocoagulation (CC)) intraocular tamponades. In...

To determine long-term outcome of intraocular antagonism vascular endothelial growth factor (VEGF) in macular oedema (ME) secondary to branch retinal vein occlusion (BRVO).A total 28 consecutive patients were treated with either intravitreal bevacizumab (IVB) or ranibizumab (IVR) the first series and evaluated after a mean follow-up 5 years for their functional anatomical outcome.Time between onset initial treatment was 5.2 ± 0.4/0.1 0.1 (IVB/IVR) months. A 4 injections given per 6 In months...

In Brief Purpose: To develop a classification approach based solely on spectral domain optical coherence tomography to differentiate macular edema (ME) of different disease entities and determine underlying pathology. Methods: A cross-sectional study including 153 participants: 27 with Irvine–Gass, 31 uveitic ME, 24 ME after branch retinal vein occlusion, 13 central 44 diabetic 14 controls. Spectral was graded according standardized reading protocol. Grading characteristics were: pattern in...

Abstract Purpose To determine microvascular changes in children with a history of retinopathy prematurity (ROP) and control group full‐term children. Methods In cross‐sectional study, 30 eyes 15 aged 6–8 years ROP were evaluated swept‐source optical coherence tomography angiography (SS‐OCTA). Twenty‐eight 22 age‐matched served as healthy group. The foveal avascular zone (FAZ), vessel density (VD) choroidal vascular flow area (VFA) on OCTA correlated central retinal thickness (CRT), visual...

The aim of the study was to compare intravitreal cytokines and chemokines clinical parameters in patients with rhegmatogenous retinal detachment (RRD).In this prospective vitreous samples were taken undiluted from 60 RRD 20 age-matched controls idiopathic epiretinal membranes at beginning primary vitrectomy. following assessed prior surgery: number quadrants detached, RD height, lens status, symptom duration, refractive power. Concentrations 40 different proteins eyes measured by multiplex...

To evaluate anatomical and functional outcomes of macula-on macula-off rhegmatogenous retinal detachment (RRD) after 23-gauge vitrectomy gas endotamponade, in eyes successful cataract surgery.Forty-six pseudophakic 46 consecutive patients who underwent surgery for RRD repair were included. Based on the severity degree extension RRD, diluted C3F8, SF6 or C2F6 gases used endotamponade. Patients followed 1 month, 3 months, 6 months 12 surgery. Main outcome variables anatomic till...

To assess the efficacy of a combination therapy intravitreal ranibizumab together with dexamethasone implant in comparison monotherapy neovascular age-related macular degeneration.Forty eyes recurrent or persistent degeneration were included this prospective study. Patients randomly assigned to two groups. Based on pro re nata treatment regimen, first group received (IVM). The second and (intravitreal [IVC]) at baseline was retreated as needed. A allowed for retreatment after least 6 months....

Purpose: To compare area measurements between swept source optical coherence tomography angiography (SSOCTA), fluorescein (FA), and indocyanine green (ICGA) after applying a novel deep-learning-assisted algorithm for accurate image registration. Methods: We applied an the segmentation of blood vessels in FA, ICGA, SSOCTA images 24 eyes with treatment-naive neovascular age-related macular degeneration. trained model based on U-Net Mask R-CNN each imaging modality using vessel annotations...

To evaluate changes in intraocular pressure after congenital cataract surgery a real-world setting.This retrospective case series included all children aged 0-2 years undergoing lens extraction due to cataract. Development of an elevated was divided into three groups: secG, suspG and OHT. Further, risk factors for IOP changes, the therapeutic approach functional outcome were assessed during follow-up.One hundred sixty-one eyes 110 patients included, whereof 29 17 developed secondary glaucoma...

Purpose To evaluate the functional and morphological outcomes of patients with SO tamponade due to primary rhegmatogenous retinal detachment (primRD) recurrent (recRD).Methods Seventy-five eyes were enrolled in this prospective study between January 2009 December 2016. Patients primRD recRD evaluated a complete ophthalmic examination including best-corrected visual acuity (BCVA) OCT before after silicone oil removal (SOR).Results The group comprised 35 40 duration 9 ± 4/12 11 months...

To assess the characteristics and long-term outcomes of adult patients with dysthyroid optic neuropathy (DON) who underwent orbital decompression surgery and/or received intravenous (IV) methylprednisolone.Retrospective chart review 98 eyes 49 were diagnosed treated bilateral DON between 2007 2018 at Department Ophthalmology Optometry Oral Maxillofacial Surgery Medical University Vienna.The mean follow-up period was 4.1 ± 2.7 years. The most common presenting symptoms eyelid periorbital...

The purpose of this study was to identify quantitatively measurable morphologic optical coherence tomography (OCT) characteristics in patients with an acute episode central serous chorioretinopathy (CSC) and evaluate their correlation functional psychological variables for use daily clinical practice.Retinal thickness (RT), the height, area volume subretinal fluid (SRF)/pigment epithelium detachments were evaluated using standardized procedures Vienna Reading Center. These compared...

Purpose: To investigate the effects of intravitreal 0.7 mg dexamethasone implants (Ozurdex) on arterial and venous oxygen saturation, retinal vessel diameter, retrobulbar blood flow velocity in patients with macular edema (ME) due to vein occlusion (RVO). Methods: This prospective, nonrandomized clinical trial included 40 eyes ME RVO. Measurements saturation diameters were performed using Dynamic Vessel Analyzer. The main outcome measure was arteriovenous difference, calculated as difference...

The aim of this study was to evaluate and compare the underlying pathologies, demographic retinal detachment characteristics in pediatric early adulthood detachment.Patients with rhegmatogenous, serous, or tractional aged 0-26 years were retrospectively reviewed. preschool group (n = 4) comprised children 0-6 years, 19) 7-16 13) 17-26 years. Demographic information characteristics, type surgery, intraocular tamponade analyzed. Postoperatively, functional outcome, anatomic success, ocular...

Background To evaluate the long-term results after hypofractionated stereotactic photon radiotherapy (SRT) in patients with choroidal melanoma treated between 1997 and 2016.Material methods A total of 335 (183 male 152 female) unsuitable for ruthenium-106 brachytherapy or local resection were linear accelerator-based SRT at Medical University Vienna. All received five fractions either 10, 12 14 Gy per fraction. complete ophthalmic examination including visual acuity measurement tumor base...

Abstract Purpose To differentiate retinoschisis ( RS ) from non‐acute retinal detachment (na RD in clinical routine using optical coherence tomography OCT ), describe unique morphological characteristics and monitor disease progression. Methods This prospective, observational study included 64 eyes of 44 patients with either or na . Patients were examined clinically Heidelberg Spectralis ® , Topcon DRI Cirrus HRA ‐ over 2 years follow‐up at 1, 3, 6, 12 24 months. Main outcomes typical...

In Brief Purpose: To evaluate the 3-year therapeutic benefit of intravitreal bevacizumab in neovascular related macular degeneration (nAMD) a standard clinical setting involving 3 initial injections and pro re nata regimen as recommended PRONTO study. Methods: this interventional study, 181 eyes 160 consecutive patients with active meeting criteria for inclusion protocol anti–vascular endothelial growth factor therapy undergoing monotherapy were observed. Data treatment-naive (Group 1, n =...

Purpose: To prospectively evaluate the outcomes of different subtypes neovascular age-related macular degeneration during intravitreal aflibercept monotherapy. Methods: Forty-four eyes 44 patients with treatment-naïve polypoidal choroidal vasculopathy (PCV, n = 12), hemorrhagic neovascularization (hCNV, pigment epithelium detachment (PED, 11), or retinal angiomatous proliferation (RAP, 9) were included and followed for 12 months. All received Results: Mean visual acuity at baseline in PCV...