To investigate concentrations of growth factors and inflammatory cytokines in eyes with central (CRVO) branch (BRVO) retinal vein occlusion before during therapy bevacizumab to identify associations disease activity.In a prospective clinical trial, 13 patients CRVO (n = 5) or BRVO 8) were included. Bevacizumab was administered intravitreously at baseline months 1 2. Retreatments given monthly visits if OCT showed edema when vision loss occurred. Aqueous humor samples taken each time...

<h3>Aims:</h3> The aim of the study was to evaluate functional and anatomical changes after intravitreal bevacizumab (Avastin®) in eyes with persistent macular oedema secondary branch retinal vein occlusion (BRVO) or central (CRVO). <h3>Methods:</h3> Twenty-nine consecutive BRVO (21 eyes) CRVO (eight were included a prospective clinical trial. Eyes treated three initial injections 1 mg at monthly interval. Retreatment based on thickness (CRT) optical coherence tomography. If continuous...

<h3>Objective:</h3> To evaluate efficacy and safety of intravitreal bevacizumab (Avastin) in eyes with macular oedema secondary to central retinal vein occlusion (CRVO) or branch (BRVO). <h3>Methods:</h3> Twenty-eight consecutive patients (28 patients, 29 eyes, 8 CRVO, 21 BRVO) were enrolled the study. Three injections 1 mg (0.04 ml) administered at 4-week intervals; further retreatment was based on optical coherence tomography (OCT) findings. Follow-up examinations done days 1, 7 28 monthly...

The purpose of this study was to determine the concentrations angiogenic and inflammatory markers in human eyes with diffuse diabetic macular edema before during therapy intravitreal bevacizumab their association disease activity.In a prospective clinical trial, 10 consecutive patients vision loss because were compared age-matched controls. Bevacizumab administered at baseline; retreatments given monthly according activity. During follow-up 6 months, aqueous humor samples taken each time...

Background and Purpose— There is considerable variability in the antiplatelet effects of thienopyridine agent “clopidogrel.” We tested for an association gene sequence variations P2Y12 occurrence neurological adverse events patients with symptomatic peripheral artery disease (PAD) during clopidogrel treatment. Methods— studied 137 undergoing therapy 336 aspirin (ischemic stroke and/or carotid revascularization). Prevalence 2 previously described exonic polymorphisms gene, 34C&gt;T 52G&gt;T,...

The purpose of this study was to investigate epithelial and neuronal changes in patients with refractory/relapsed multiple myeloma (RRMM) before/during belantamab mafodotin (belamaf) treatment using confocal microscopy.Retrospective case series.RRMM underwent best-corrected visual acuity (BCVA) testing slitlamp examination/photography, followed by corneal microscopy (CCM), evaluate the epithelium subbasal nerve plexus (SNP) measure fiber density (CNFD), branch (CNBD), length (CNFL) before...

A frequent polymorphism in the factor XIII (FXIII) A-subunit gene, leading to a Val Leu amino acid exchange at position 34, suggested affect clot stability, has been associated with decreased risk for venous thromboembolism and myocardial infarction. Its role development of stroke is still under investigation. Ninety-four patients primary arterial intracerebral haemorrhage (mean age +/- standard deviation: 69 14 years; 48 men, 46 women), 718 ischaemic (63 395 323 women) 369 healthy control...

To identify and quantify angiogenic inflammatory cytokines in aqueous vitreous humor eyes with untreated uveal melanoma to analyze clinicopathologic correlations.Intraocular fluid samples of patients (uveal n = 21, 34) controls (cataract 41, vitreomacular traction 35, 36) were taken intraoperatively analyzed using Luminex xMAP suspension array technology. Beadlyte kits used for detection 28 different cytokines.Flt-3 ligand, interleukin (IL) 1α, IL-6, IL-8, interferon-γ inducible protein...

The aim of the study was to compare intravitreal cytokines and chemokines clinical parameters in patients with rhegmatogenous retinal detachment (RRD).In this prospective vitreous samples were taken undiluted from 60 RRD 20 age-matched controls idiopathic epiretinal membranes at beginning primary vitrectomy. following assessed prior surgery: number quadrants detached, RD height, lens status, symptom duration, refractive power. Concentrations 40 different proteins eyes measured by multiplex...

To evaluate ultrastructural changes in low-density lipoprotein (LDL) receptor knockout (R(-/-)) mice consuming different diets as a potential model of Bruch membrane (BM) lipoidal degeneration and to determine the distribution concentration VEGF(164) this mouse model.Eight-month-old LDL-R(-/-) wild-type controls were fed standard or high-fat diet. Animals killed, plasma cholesterol levels determined. Using transmission electron microscopy, BM thickness, lipid vacuole size, retinal pigment...

recent discovery of other CYP2C9 allelic variants (10, 11 ), adaptations this method could allow detection these variants.

Zusammenfassung Die großen Fortschritte in der Entwicklung von Bildgebungstechniken Augenheilkunde haben auch bei Uveitiserkrankungen unsere Mittel zur Diagnosestellung und Verlaufsbeobachtung erheblich erweitert verbessert. Dieser Artikel soll einen aktuellen Überblick bieten über spezielle Aspekte, die bildgebenden Verfahren dieser Patientengruppe zu beachten sind. Möglichkeiten Darstellung Aderhaut, Vor- Nachteile optischen Kohärenztomographie-Angiographie (OCT-A), Weitwinkelbildgebung...

A Thr>Pro polymorphism at codon 715 in the coding region of P-selectin gene has recently been described. Individuals carrying Pro715 allele were reported to have a reduced risk myocardial infarction. possible association this with ischemic stroke is currently under discussion.We investigated prevalence 450 patients aged younger than 60 years or transient attack and controls without vascular disease matched for age gender. We also interactions other factors, severity etiology.The distribution...

We performed a multicenter case–control study to evaluate the impact of glycoprotein 1b alpha (−5)T/C Kozak polymorphism on risk ischemic cerebrovascular events. The genetic analysis in 1399 patients (745 men; median age, 70 years; interquartile ratio, 58–78) and 1066 control subjects (549 47 39–59) was carried out with mutagenically separated polymerase chain reaction. Homozygous C/C genotype carriers had 3.5-fold increased for cerebrovasular events (95% confidence interval, 1.5–7.9, P =...

Coagulation factor VII (FVII) plays an important role in the activation of blood coagulation and clot formation. Recent studies have provided evidence for association between common polymorphic markers FVII gene plasma concentrations. The 353R>Q sequence variation, 3 variations promoter gene-the 10-bp insertion/deletion at position -323 -401G>T -402G>A variations-are well-known determinants circulating concentrations.To clarify these pathogenesis ischemic stroke, we performed a case-control...

investment and ease of use for the many laboratories that continue to do their own genotyping.

Data concerning genetic factors that may influence the risk of primary intracerebral hemorrhage (PICH) are scarce. One previous study, indicated carriers (-323)Ins allele coagulation factor VII (FVII) have an increased PICH. Another recent tested effect apolipoprotein E. We analyzed, whether (-401)G --> T polymorphism, which is in linkage disequilibrium (LD) with 10-bp Ins/Del polymorphism at position (-323), or (-402)G A polymorphisms FVII gene associated for performed a small case-control...