A5019909507- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
- Reproductive Health and Technologies
- Genomic variations and chromosomal abnormalities
- Fetal and Pediatric Neurological Disorders
- Birth, Development, and Health
- Sperm and Testicular Function
- Congenital limb and hand anomalies
- Reconstructive Surgery and Microvascular Techniques
- Ectopic Pregnancy Diagnosis and Management
- COVID-19 and Mental Health
- Pregnancy and preeclampsia studies
- Health disparities and outcomes
- Nutrition, Genetics, and Disease
- Genetic Syndromes and Imprinting
- Cardiovascular Health and Risk Factors
- Glycogen Storage Diseases and Myoclonus
- Genetically Modified Organisms Research
- Housing, Finance, and Neoliberalism
- Biomedical Research and Pathophysiology
- Orthopedic Surgery and Rehabilitation
- Reproductive Biology and Fertility
- Lysosomal Storage Disorders Research
- Homelessness and Social Issues
- Tumors and Oncological Cases
Murdoch Children's Research Institute
2017-2023
The University of Melbourne
2020-2022
Gateshead Health NHS Foundation Trust
2021
Royal Children's Hospital
1969-2017
Abstract More than 7 million individuals have been conceived by Assisted Reproductive Technologies (ART) and there is clear evidence that ART associated with a range of adverse early life outcomes, including rare imprinting disorders. The periconception period embryogenesis are widespread epigenetic remodeling, which can be influenced ART, effects on the developmental trajectory in utero, potentially health throughout life. Here we profile genome-wide DNA methylation blood collected newborn...
Approximately 1 in 20 men are sub-fertile or infertile yet the aetiologies of male infertility remain largely unexplained. It is suggested that lifestyle choices and environmental factors contribute but research limited. In particular, no study has evaluated early life exposures subsequent infertility. To address this knowledge gap, aims to characterise a cohort with idiopathic compare their general health, from teenage years onwards without reproductive abnormalities.Two groups (N = 500...
This qualitative study explored the psychosocial concerns of children born with congenital hand and upper limb differences (CHULDs) from point view these their parents. Qualitative, in-depth, semi-structured interviews were conducted face-to-face eight parent–child dyads. Open format questions allowed spontaneous emergence relevant themes, followed by guided questioning. Thematic analysis audio-recorded transcribed found that as young 5 years old had unique meaningful opinions about CHULD,...
Is ART related with the association of American Heart Association (AHA) ideal cardiovascular health score and markers subclinical atherosclerosis?The associations between AHA atherosclerosis in non-ART groups were similar magnitude.Long-term consequences on are unknown.The study cohort for cross-sectional analyses consisted 172 ART-conceived 78 conceived individuals same age (range 22-35 years).Cardiovascular risk factor status was evaluated consisting seven factors (body mass index, blood...
Abstract Background There are no established guidelines for the follow up of infants born after a prenatal diagnosis genomic copy number variant (CNV), despite their increased risk developmental issues. The aims this study were (i) to determine perinatal outcomes fetuses diagnosed with and without CNV, (ii) establish population-based paediatric cohort long term up. Methods An Australian state-wide research database was screened pregnant individuals who had chromosomal microarray (CMA)...
Abstract Background The implementation of genomic testing in pregnancy means that couples have access to more information about their child’s genetic make-up before birth than ever before. One the resulting challenges is management variations with unclear clinical significance. This population-based study will help close this critical knowledge gap through a multidisciplinary cohort children and without copy number variants (CNVs) diagnosed birth. By comparing prenatally-ascertained CNVs...
Numerous studies have investigated the physical health and development of children adolescents conceived with assisted reproductive technology (ART). Less is known about quality life ART-conceived adults. This study explores contributions being ART psychosocial cofactors present in young adulthood to adults aged 22-35 years. Young through or natural conception (NC) completed questionnaires which included a standardized measure (World Health Organization Quality Life - Brief assessment...
Children with a congenital upper limb difference (CoULD) are diverse group who often require multidisciplinary care and long-term support for functional social impacts. The Australian Hand Difference Register (AHDR) provides national database of children born CoULD aims to facilitate research improve health affected children. Using data from the first 3 years its operation, we analysed demographic clinical features participating families, including type CoULDs frequency pre-natal syndromic...
<b>Background:</b> Approximately 4% of babies born in Australia are conceived by assisted reproductive technologies (ART). The artificial procedures used during ART raises the risk profile adult-onset chronic health problems, including respiratory conditions, compared with naturally children. Our aim was to determine whether adults have altered lung function age- and sex-matched controls. <b>Methods:</b> As part a large cohort study Victoria, Australia, participants performed spirometry...
Background: A four-stream research program, Men and Infertility over the Lifecourse, is funded by MRFF to address medical, personal social cost of idiopathic male infertility. This program includes a national case control study: AMIE. Designing implementing AMIE poses both opportunities challenges.
Background: We have an established cohort of singleton adults conceived by IVF and GIFT born from January 1982 to December 1992, matched controls without assisted reproduction (non-ART). They participated in two previous studies: 1) a telephone interview study when aged 21 years on average 2) clinical review 6 later. As these are reaching the age first-time parents, it is important determine their reproductive health. Aim: To examine health IVF/GIFT-conceived compared non-ART controls....