A5074899729- Acute Ischemic Stroke Management
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Stroke Rehabilitation and Recovery
- Advanced Neuroimaging Techniques and Applications
- Neurological and metabolic disorders
- Cerebral Venous Sinus Thrombosis
- Infectious Encephalopathies and Encephalitis
- Long-Term Effects of COVID-19
- Metabolism and Genetic Disorders
- Genetic Neurodegenerative Diseases
- Genomics and Rare Diseases
- Advanced MRI Techniques and Applications
- Healthcare Decision-Making and Restraints
- SARS-CoV-2 and COVID-19 Research
- Neurological diseases and metabolism
- Fetal and Pediatric Neurological Disorders
- Cystic Fibrosis Research Advances
- Venomous Animal Envenomation and Studies
- Amyotrophic Lateral Sclerosis Research
- Atomic and Subatomic Physics Research
- Sleep and Wakefulness Research
- Ophthalmology and Eye Disorders
- Lysosomal Storage Disorders Research
- Sleep and Work-Related Fatigue
Monash University
2020-2024
Universiti Teknologi MARA
2021-2024
Hospital Sungai Buloh
2024
Alfred Health
2021-2023
The Alfred Hospital
2020-2021
Liverpool Hospital
2019-2020
UNSW Sydney
2020
Camden and Campbelltown Hospitals
2019
Western Sydney University
2019
Western Health
2017
Dystonia is a clinically and genetically heterogeneous disorder genetic cause often difficult to elucidate. This the first study use whole genome sequencing (WGS) investigate dystonia in large sample of affected individuals.WGS was performed on 111 probands with heterogenous phenotypes. We analysis for coding non-coding variants, copy number variants (CNVs), structural (SVs). assessed an association between 10 known risk variants.A diagnosis obtained 11.7% (13/111) individuals. found that...
Some constituents of snake venom have been found to display a variety biological activities. The antibacterial property venom, in particular, has gathered increasing scientific interest due antibiotic resistance. In the present study, king cobra was screened against three strains Staphylococcus aureus [including methicillin-resistant (MRSA)], other species gram-positive bacteria and six gram-negative bacteria. King active all 12 tested, most effective spp. (S. S. epidermidis). Subsequently,...
There are increasing reports of myasthenia gravis (MG) following oncological treatment with immune checkpoint inhibitors (ICIs).A 66-year-old man stage 3A lung adenocarcinoma was treated second weekly infusions durvalumab, a programmed cell death ligand-1 inhibitor, at dose 10 mg/kg. After the fourth infusion, he developed diplopia, dyspnoea and constitutional symptoms including headache, weakness anorexia. 1 month later, dysphagia dysphonia. Examination showed proximal limb fatigability. An...
An 18-year-old male presented with new-onset focal to bilateral tonic-clonic seizures 5 days after receiving the first dose of COVID-19 vaccine. 3 later, an identical seizure occurred lasting 1 min, leading acute presentation hospital. In hospital, patient was loaded intravenous phenytoin and started on levetiracetam no further recurrence. CT venogram scalp EEG were unremarkable. MRI brain revealed generalised atrophy mild hippocampal atrophy. The maintained 500 mg twice daily advised...
Idarucizumab can lead to acute thrombosis in a patient with an underlying procoagulant state.
Motor neuron disease (MND) is a neurodegenerative disorder leading to functional decline and death. Multidisciplinary MND clinics provide an integrated approach management facilitate discussion on advanced care directives (ACDs). The study objectives are analyse (1) the prevalence of ACD in our clinic, (2) relationship between patient demographics (3) decision-making variables such as NIV, PEG, hospital admissions location death.Using clinic records, all patients who attended Liverpool...
Abstract Introduction As more novel COVID-19 vaccines are being rolled out in a frantic pace globally, any complication that might be related to should highlighted, especially since relatively new, and side effects may yet fully elucidated. We report case of healthy 18-year-old male who presented with new onset focal seizures 5 days after receiving 1 st dose Oxford/AstraZeneca vaccine. Case Presentation The patient was treated intravenous phenytoin oral levetiracetam 250mg twice daily no...
T2 relaxation times (T2 times) are different between resting and exercised muscles of healthy subjects with muscle pathology. However, studies specifically focusing on neck lacking. Furthermore, normative not well defined methodology used to analyse in is robust. We analysed key explored factors affecting variability muscles. 20 were recruited. Two circular regions interest (ROIs) drawn two mutually exclusive within weighted images values averaged. ROI measurements performed by a...
<h3>Objectives</h3> T2 relaxation times (T2RT) of muscles increase with physical exercise, however T2RT has not been studied in dystonic are a state constant activity. Major involved cervical dystonia (CD) include splenius capitis, semispinalis levator scapulae, sternocleidomastoid and trapezius which also prime targets for botulinum toxin treatment. This study analysed the T2RTs key neck CD, compared them normal subjects. <h3>Methods</h3> 23 CD subjects underwent MRI clinical assessment...
Pseudochoreoathetosis is a rare movement disorder associated with loss of proprioception. Culprit lesions may occur at any point between the cerebral cortex and peripheral nerve. Seldom underlying cause reversible or prone to improvement. An elderly man presented our tertiary centre choreoathetoid movements secondary spondylotic subaxial cervical myelopathy. His myelopathy fulminated he was emergently treated posterior decompressive neurosurgery. Unexpectedly, his improved significantly...