A5028768289- Schizophrenia research and treatment
- Mental Health Research Topics
- Mental Health and Psychiatry
- Functional Brain Connectivity Studies
- Psychiatric care and mental health services
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Bipolar Disorder and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Educational and Psychological Assessments
- Neuroscience and Music Perception
- Mental Health Treatment and Access
- Electroconvulsive Therapy Studies
- Cognitive Abilities and Testing
- Tryptophan and brain disorders
- Health Systems, Economic Evaluations, Quality of Life
- Digital Mental Health Interventions
- Resilience and Mental Health
- Mental Health and Patient Involvement
- Personality Disorders and Psychopathology
- Disability Education and Employment
- Cognitive Functions and Memory
- Neurobiology of Language and Bilingualism
- Neurotransmitter Receptor Influence on Behavior
- Pharmaceutical Economics and Policy
- Obsessive-Compulsive Spectrum Disorders
King's College London
2016-2025
Lewisham and Greenwich NHS Trust
2021-2024
Queen Elizabeth Hospital
2021
NIHR Maudsley Dementia Biomedical Research Unit
2020
King's College School
2018-2019
South London and Maudsley NHS Foundation Trust
2016
Oxleas NHS Foundation Trust
2013-2015
King's College - North Carolina
2012
Psychiatry Research Trust
2000-2003
Horton General Hospital
1996
Approaches to cognitive remediation have differed across studies. Most of the larger studies concentrated on group treatments designed without benefit recent laboratory-based The current study describes a randomized trial an intensive program involving individual daily sessions 1 hour for up 3 months. It targets executive functioning deficits (cognitive flexibility, working memory, and planning) that are known be problematic in people with schizophrenia. Procedural learning, as well...
Background Cognitive difficulties are prevalent in people with a diagnosis of schizophrenia and associated poor long-term functioning. Aims To evaluate the effectiveness cognitive remediation therapy on experienced by schizophrenia. Method Participants schizophrenia, social behaviour problem difficulty ( n =85) were randomised to 40 sessions or treatment as usual single-blind controlled trial. Working memory, flexibility planning, measured at weeks 0, 14 40. Results There durable...
The results of one randomised control trial testing a psychological rehabilitation programme aimed at information processing strategies showed improvements in cognition post-treatment.To determine whether there are concomitant brain activation changes as result engaging cognitive remediation therapy (CRT).Three groups (patients receiving or CRT and healthy group) were investigated repeated measures design using the two-back test. Functional magnetic resonance imaging (fMRI) data broad...
Background Cognitive remediation (CR) is a psychological therapy, which improves cognitive and social functioning in people with schizophrenia. It now being implemented within routine clinical services mechanisms of change are explored. We designed new generation computerised CR programme, CIRCuiTS (Computerised Interactive Remediation Cognition – Training for Schizophrenia), to enhance strategic metacognitive processing, an integrated focus on the transfer skills daily living. This large...
Background: Despite the boom in new technologically based interventions for people with psychosis, recent studies suggest medium to low rates of adherence these types interventions. The benefits will be limited if only a minority service users adhere and engage; specific predictors can identified then technologies adapted increase user benefits. Objective: study aimed present systematic review adherence, dropout, approaches analyzing newly developed mobile Web-based psychosis. Specific were...
Abstract Background and Hypothesis Cognitive remediation (CR) benefits cognition functioning in psychosis but we do not know the optimal level of therapist contact, so evaluated potential different CR modes. Study Design A multi-arm, multi-center, single-blinded, adaptive trial therapist-supported CR. Participants from 11 NHS early intervention services were independently randomized to Independent, Group, One-to-One, or Treatment-as-usual (TAU). The primary outcome was functional recovery...
Background: Cognitive remediation (CR) is a psychological therapy, effective in improving cognitive performance and functioning people with schizophrenia. As the therapy becomes more widely implemented within mental health services its longevity uptake likely to depend on feasibility acceptability service users clinicians. Aims: To assess of new strategy-based computerized CR programme (CIRCuiTS) for psychosis. Method: Four studies were conducted using mixed methods. Perceptions...
Cognitive remediation therapy (CRT) for schizophrenia has been effective in improving cognitive and global functioning outcomes. It is now important to determine what factors maximize benefit. The quality of relationship—or working alliance—between clients therapists may be one such factor that improves outcome. To investigate this, 49 individuals with were recruited into a naturalistic study the impact CRT on work structured activity Participant's skills, severity symptoms, social skills...
Cognitive remediation therapy (CRT) may benefit people with bipolar disorder type I and II for whom cognitive impairment is a major contributor to disability. Extensive research has demonstrated CRT improve cognition psychosocial functioning in different diagnoses, but randomised trials of evidenced programmes are lacking disorders. The Remediation Bipolar (CRiB) study aimed determine whether an established programme feasible acceptable disorders.This proof-of-concept, single-blind trial...
Abstract Background To provide precision cognitive remediation therapy (CR) for schizophrenia, we need to understand whether the mechanism improved functioning is via cognition improvements. This has not been rigorously tested potential moderator effects. Study Design We used data (n = 377) from a randomized controlled trial using CIRCuiTS, therapist-supported CR, with participants first-episode psychosis services. applied structured equation modeling test whether: (1) CR hours explain goal...
This study examined the link between executive function and functional outcome in schizophrenia to identify useful psychological intervention targets explore how changes affect social functioning symptoms. Participants from two randomized controlled trials (n = 63) with poor functioning, positive negative symptoms, cognitive impairment completed seven measures of function. Three factors were extracted: verbal working memory, response inhibition speed, stimulus-driven responding. received...
A greater understanding of the links between cognitive and social functioning changes is needed to refine treatments for schizophrenia. To date, studies have been cross-sectional, few investigated impact change. This single-blind randomized controlled trial explored in executive/memory functions behavior, as well moderating effect remediation therapy (CRT). total 85 participants with schizophrenia received 40 sessions CRT (an individual psychological aiming improve attention, memory, problem...
Cognitive remediation (CRT) affects functioning but the extent and type of cognitive improvements necessary are unknown.To develop test models how improvement transfers to work behaviour using data from a current service.Participants (N49) with support worker paid or voluntary job were offered CRT in Phase 2 single group design three assessments: baseline, post therapy follow-up. Working memory, flexibility, planning outcomes assessed.Three tested (mediation - drive improvement; moderation...
Background Cognitive remediation (CR) preceding cognitive–behavioural therapy for psychosis (CBTp) was trialled within routine clinical services, with the hypothesis that following first-episode non-affective CR would enhance CBTp efficacy by improving neuropsychological performance. Method A total of 61 patients DSM-IV psychoses waiting were randomized to computerized over 12 weeks, supported a trained support worker, or time-matched social contact (SC). Primary outcome blind-rated...
Abstract Background Although cognitive remediation (CR) improves cognition and functioning, the key features that promote or inhibit its effectiveness, especially between domains, remain unknown. Discovering these will help to develop CR for more impact. Aim To identify interrelations cognition, symptoms, using a novel network analysis approach how affects recovery outcomes. Methods A secondary of randomized controlled trial data (N = 165) in early psychosis. Regularized partial correlation...
Background People with a diagnosis of schizophrenia have limited metacognitive awareness their symptoms. This is also evident for cognitive difficulties when neuropsychological assessments and self-reports are compared. Unlike delusions hallucinations, little attention has been given to factors that may influence the mismatch between objective subjectively reported problems. Symptom severity, self-esteem social functioning, can an impact on problem perception help explain gap subjective in...
The cognitive problems experienced by people with schizophrenia not only impede recovery but also interfere treatments designed to improve overall functioning. Hence there has been a proliferation of new therapies treat the hope that improvements will benefit future intervention and outcomes. Cognitive remediation therapy (CR) relies on intensive task practice can support basic functioning is little evidence how these lead transfer real life skills. However, increasing CR including elements...
Converging research suggests that individuals with schizophrenia show a marked impairment in reinforcement learning, particularly tasks requiring flexibility and adaptation. The problem has been associated dopamine reward systems. This study explores, for the first time, characteristics of this how it is affected by behavioral intervention-cognitive remediation.Using computational modelling, 3 learning parameters based on Wisconsin Card Sorting Test (WCST) trial-by-trial performance were...
Cognitive problems are consistently documented in people with schizophrenia. They negatively influence functioning and contribute to the long term consequences of illness. remediation (CR) is a psychological intervention developed target these cognitive difficulties. There evidence that CR beneficial but there still limited understanding how putative active therapy ingredients changes brain translate into improved functioning. This paper reviews recent research focused on topics that, our...
Background and Aims: Schizophrenia leads to significant personal costs matched by high economic costs. Cognitive function is a strong predictor of disabilities in schizophrenia, which underpin these This study cognitive remediation therapy (CRT), has been shown improve cognition reduce disability aims investigate associations between improvements cost changes. Methods: Eighty-five participants with schizophrenia were randomized receive CRT or treatment as usual assessed at baseline,...