A5100698842- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- ATP Synthase and ATPases Research
- Dementia and Cognitive Impairment Research
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- NF-κB Signaling Pathways
- Chronic Kidney Disease and Diabetes
- Paraoxonase enzyme and polymorphisms
- RNA modifications and cancer
- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Blood Coagulation and Thrombosis Mechanisms
- Advanced Graph Neural Networks
- Advanced Neuroimaging Techniques and Applications
- Protease and Inhibitor Mechanisms
- Advanced Glycation End Products research
- Peripheral Artery Disease Management
- Cell death mechanisms and regulation
- Memory and Neural Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Cytokine Signaling Pathways and Interactions
Peking University First Hospital
2012-2024
Peking University
2012-2024
General Hospital of Shenyang Military Region
2014
The primate dorsolateral prefrontal cortex (dlPFC) subserves top-down regulation of attention and working memory abilities. Depletion studies show that the neuromodulator acetylcholine (ACh) is essential to dlPFC functions, but receptor cellular bases for cholinergic actions are just beginning be understood. current study found nicotinic receptors comprised α4 β2 subunits (α4β2-nAChR) enhance task-related firing delay fixation cells in monkeys performing a task. Iontophoresis α4β2-nAChR...
It is known that decreased apoptosis of thyrocytes may be involved in the formation goiters patients with Graves’ disease, and growth factors are regulating size thyroid gland. The purpose our study was to investigate mRNA protein levels an antiapoptotic protein, namely, Fas-associated death domain-like interleukin-1-converting enzyme (FLICE)-inhibitory (FLIP). results showed FRTL cells, treatment IGF-I upregulated FLIP a dose-dependant manner. While specific nuclear factor-κB (NF-κB)...
High-fat diet (HFD) is the primary cause of metabolic syndrome associated chronic kidney disease. This study aimed to investigate pathogenesis HFD-induced injury. ApoE-/- mice were fed with HFD and damage was examined. In addition, HK-2 human renal proximal tubular epithelial cells treated fructose receptor advanced glycation end products (RAGE) siRNA. The results showed that increased body weight, blood glucose insulin resistance in mice. oxidative stress strong staining RAGE NF-κB tissues,...
<h3>Background</h3> Paraoxonase 1 (PON1) is a plasma enzyme that capable of inhibiting the progression atherosclerosis, and significantly associated with susceptibility coronary artery disease (CAD). Recently, PON total protein expression was found in human aortic tissue it played an important role atherosclerosis. For studying its crucial preventing CAD, we performed PON1 immunohistochemical analysis arteries, explored polymorphisms status, analysed association risk CAD. <h3>Methods</h3>...
Abstract Alzheimer’s disease (AD) is a common neurodegenerative in the elderly, early diagnosis and timely treatment are very important to delay course of disease. In past, most brain regions related AD were identified based on imaging method, which can only identify some atrophic regions. this work, we used mathematical models find out potential AD. First, diffusion tensor (DTI) was construct structural network. Next, set new local feature index 2hop-connectivity measure correlation among...