A5101919439- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Infections and bacterial resistance
- Urinary Tract Infections Management
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Vibrio bacteria research studies
- Bacterial biofilms and quorum sensing
- Infective Endocarditis Diagnosis and Management
- Pharmaceutical and Antibiotic Environmental Impacts
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Bacterial Infections and Vaccines
- Amoebic Infections and Treatments
- Streptococcal Infections and Treatments
- Nosocomial Infections in ICU
- Disaster Response and Management
- Plant Pathogenic Bacteria Studies
- Infectious Diseases and Tuberculosis
- Burn Injury Management and Outcomes
- Antifungal resistance and susceptibility
- Mycobacterium research and diagnosis
- COVID-19 Clinical Research Studies
- Central Venous Catheters and Hemodialysis
National Defense Medical Center
2014-2024
Tri-Service General Hospital
2014-2024
National Tsing Hua University
2016
National Health Research Institutes
2016
China Medical University
2016
China Medical University Hospital
2016
University of Houston
2016
Taoyuan Armed Forces General Hospital
2010
National Yang Ming Chiao Tung University
2009
Rationale: Systemic inflammation has emerged as a key pathophysiological process that induces multiorgan injury and causes serious human diseases. Endothelium is critical in maintaining cellular inflammatory homeostasis, controlling systemic inflammation, progression of We postulated endothelium produces releases endogenous soluble factors to modulate responses protect against inflammation. Objective: To identify endothelial cell–released barrier dysfunction Methods Results: found...
Acinetobacter baumannii biofilms are difficult to eradicate. We investigated the effects of meropenem (2 mg/liter), imipenem sulbactam (4 colistin and tigecycline alone or in combination, on biofilm-embedded carbapenem-resistant carbapenem-susceptible A. (CRAb CSAb, respectively) cells, as well architecture biofilms. ATCC 15151 (Ab15151) its OXA-82-overproducing transformant, along with two clinical CSAb CRAb isolates differing clonalities, were used. The minimal bactericidal concentrations...
Acinetobacter baumannii is an important nosocomial pathogen worldwide. Its role in community-acquired infection remains controversial and has rarely been reported. Patients with monobacterial bloodstream infections caused by genomic species identified A. baumannii, admitted to Taipei Veterans General Hospital between 1999 2010, were selected as cases. Controls defined patients acquiring a healthcare setting matched for age sex. The clinical, epidemiologic, microbiological characteristics of...
Minocycline-based combination therapy has been suggested to be a possible choice for the treatment of infections caused by minocycline-susceptible Acinetobacter baumannii, but its use minocycline-resistant A. baumannii is not well established. In this study, we compared efficacy minocycline-based (with colistin, cefoperazone-sulbactam, or meropenem) that colistin in with meropenem infection. From 2006 2010, 191 (17.6%) 1,083 complex isolates susceptible minocycline from Taiwan Surveillance...
The impact of bacteremia due to the resistance Stenotrophomonas maltophilia trimethoprim–sulfamethoxazole (TMP–SXT) is uncertain. This study compared clinical characteristics and outcomes patients with TMP–SXT-susceptible (TSSSM) TMP–SXT-resistant S. (TSRSM) monomicrobial bacteremia. medical records adult TSSSM TSRSM from January 2004 December 2013 were reviewed classified into two groups, namely, TSRSM. There 184 mean age was 68.3 years. Most males (72.8%), had high Charlson Comorbidity...
Recurrent Klebsiella pneumoniae liver abscesses (KLAs) are rarely reported. Six cases of recurrent KLAs characterized. Most the patients had diabetes and K1 serotype KLAs. All isolates were uniformly susceptible to cefazolin. Distinct molecular fingerprints found for strains isolated from both primary
Abstract Background Acinetobacter baumannii hospital-acquired pneumonia (HAP) is associated with a high mortality worldwide. Non-ventilated patients HAP (NVHAP) caused by nosocomial pathogens are reported to have more favorable outcome than those ventilator-associated (VAP). The current study was designed determine whether bacteremic A. NVHAP also lower receiving assisted ventilation. Methods This retrospective 10-year conducted at 2900-bed teaching hospital located in Northern Taiwan....
The emergence of Klebsiella pneumoniae carbapenemase (KPC)-producing strains is a challenge for clinicians. characteristics and virulence variants KPC-producing K. isolates were evaluated.Five clinical isolates-three KPC subtypes from Taiwan (KPC2-TW, KPC3-TW, KPC17-TW) two the United States (US; KPC2-US, KPC3-US)-were included. Virulent traits capsular serotypes analyzed by Polymerase Chain Reaction (PCR). Serum killing, neutrophil phagocytosis, mice lethargy studies performed to evaluate...
Acinetobacter ursingii bacteremia is rarely reported. We investigated the incidence and clinical features of A. bacteremia, performance identification system, antimicrobial susceptibility isolates. patients were compared with baumannii patients. In this 9-year retrospective study, was identified using 16S rRNA 16S–23S internal transcribed spacer sequence analysis. The performances Vitek 2, Phoenix, matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometer...
Community-onset urinary tract infections (CoUTIs) are the most common bacterial infections, and a decline in antibiotic susceptibility causes many clinical challenges. Adequate empiric treatment can decrease unnecessary hospital stays complications, while reducing antimicrobial resistance progression.From October 2014 to April 2015, we retrospectively enrolled patients who were at least 18 years old required hospitalization for CoUTIs. Demographic variables of these patients, uropathogens...
This retrospective observational study assessed the differences between monomicrobial and polymicrobial A. baumannii bacteremia identified possible independent risk factors for 14-day mortality. There were 379 patients with admitted to a tertiary care center in northern Taiwan August 2008 July 2015 enrolled data analysis. Among them, 89 (23.5%) had 290 (76.5%) bacteremia. No significant difference mortality was observed (26.9% vs. 29.2%, p = 0.77). Logistic regression controlled confounders...
Abstract Background It is unknown whether there are differences between bacteremia caused by carbapenem resistant Acinetobacter baumannii (CRAB) and nosocomialis (CRAN). This study aims to investigate the differences, especially in clinical outcomes, patients with CRAB or CRAN. Methods a 9-year retrospective comparing manifestations, antimicrobial susceptibilities, outcomes of 71 64 CRAN bacteremia. Results Patients were more likely have hematologic malignancies presented shock episodes than...
Bloodstream infection is a leading cause of mortality among burn patients. This study aimed to evaluate the risk factors, causative pathogens, and relationship between bloodstream infections other patients from Formosa Fun Coast Dust Explosion. retrospective evaluated demographic clinical characteristics, types, pathogen(s), isolates' antibiotic susceptibilities who were hospitalized June 27 September 31, 2015. Fifty-eight admitted during period (36 males, mean age: 22.6 years). The burned...
Abstract Objective We aimed to assess the efficacy of cefoperazone/sulbactam (CPZ/SUL) in extended-spectrum β-lactamase (ESBL)-producing Enterobacterales infections and identify factors influencing outcomes. Methods This retrospective multicentre study was conducted Taiwan (January 2015 December 2020) examined CPZ/SUL treatment ESBL-producing bacteraemia. The minimum inhibitory concentrations (MICs) were determined using agar dilution; ESBL/AmpC genes detected polymerase chain reaction....
Elizabethkingia anophelis, a nonfermenting Gram-negative bacterium, causes life-threatening health care-associated infections. E. anophelis harbors multidrug resistance (MDR) genes and is intrinsically resistant to various classes of antibiotics. Outer membrane vesicles (OMVs) are secreted by bacteria contain materials involved in bacterial survival pathogenesis. OMVs specialize tailor their functions carrying different components challenging environments allowing communication with other...