A5010342026- Microbial Natural Products and Biosynthesis
- X-ray Diffraction in Crystallography
- Magnetic and transport properties of perovskites and related materials
- Crystallization and Solubility Studies
- Advancements in Solid Oxide Fuel Cells
- Chemical Synthesis and Analysis
- Electronic and Structural Properties of Oxides
- Microbial Metabolism and Applications
- Enzyme Catalysis and Immobilization
- Genomics and Phylogenetic Studies
- Cyclization and Aryne Chemistry
- Click Chemistry and Applications
- Pharmacological Effects of Natural Compounds
- Advanced Condensed Matter Physics
- Phytochemical compounds biological activities
- Carbohydrate Chemistry and Synthesis
- Antimicrobial Peptides and Activities
- Studies on Chitinases and Chitosanases
- Synthesis and Catalytic Reactions
- Asymmetric Hydrogenation and Catalysis
- Drug Transport and Resistance Mechanisms
- Vitamin K Research Studies
Inner Mongolia University of Science and Technology
2024-2025
Shanghai Jiao Tong University
2024-2025
Central South University
2020-2021
Solid oxide fuel cells (SOFCs) have become promising devices for converting chemical energy into electrical energy. Altering the microstructure of cathode materials to enhance activity and stability oxygen reduction reaction is particularly important. Herein, Pr0.5Ba0.5Co1-XNiXO3+δ with a tetragonal perovskite structure was synthesized through sol–gel method. The polarization resistance symmetrical half-cell Pr0.5Ba0.5Co0.9Ni0.1O3+δ as 0.041 Ω·cm2 at 800 °C 0.118 lower than that cell...
F-doped PrBa0.8Sr0.2Co2O5+δ-xFx (PBSCFx, x = 0, 0.025, 0.05, 0.075, 0.1) cathode powder was synthesized by the sol-gel method. X-ray diffraction results showed that all samples doped with F exhibited a typical tetragonal perovskite structure without heterophase. doping can effectively reduce thermal expansion coefficient (TEC) of materials, which decreased from 25.3699 × 10-6 K-1 PBSC to 23.5295 PBSCF0.1. The area-specific resistance (ASR) PBSCF0.05 0.0207 Ω·cm2 at 800 °C, conductivity...
Solid oxide fuel cells (SOFCs) are a new type of power generation technology that directly converts chemical energy into electrical with advantages, such as low environmental pollution and high conversion efficiency.
Solid oxide fuel cells (SOFCs) have become promising devices for converting chemical energy into electrical energy. Altering the microstructure of cathode materials to enhance activity and stability oxygen reduction reaction is particularly important. Herein, Pr0.5Ba0.5Co1−XNiXO3+δ with a tetragonal perovskite structure was synthesized through sol–gel method. The polarization resistance symmetrical half-cell Pr0.5Ba0.5Co0.9Ni0.1O3+δ as 0.041 Ω·cm2 at 800 °C 0.118 lower than that cell...
Bohemamines (BHMs) are bacterial alkaloids containing a pyrrolizidine core with two unusual methyl groups. Herein we report the activation of BHMs biosynthesis using ribosome engineering approach. Characterization bhm gene cluster reveals that nonribosomal peptide synthetase BhmJ and Baeyer-Villiger monooxygenase BhmK responsible for formation core, which is further methylated on C-7 by methyltransferase BhmG. The 9-methyl group instead originated from nonproteinogenic amino acid...
SrFe1–xSixO3−δFy cathode materials (x = 0.05, 0.1, 0.15; y 0, 0.5) were prepared via a solid-state method. X-ray diffraction results show that the synthesized F doping samples perovskite structure. photoelectron spectroscopy findings F– anions doped into SrFe1–xSixO3−δ. Transmission electron microscopy and energy-dispersive performed to analyze microstructure element distribution in materials, respectively. Double-layer composite symmetric cells through screen printing Scanning images...
Yangpumicins (YPMs), for example, YPM A, F, and G, are newly discovered enediynes from Micromonospora yangpuensis DSM 45577, which could be exploited as promising payloads of antibody-drug conjugates. However, the low yield YPMs in wild-type strain (∼1 mg L-1 ) significantly hampers their further drug development. In this study, a combined ribosome engineering fermentation optimization strategy has been used improvement YPMs. One gentamicin-resistant M. 45577 (MY-G-1) showed higher...
The emergence of multidrug-resistant Gram-negative pathogens poses a serious threat to global health. bacteria have become increasingly recognized as underexplored sources Gram-negative-active cationic lipopeptide (CLP) antibiotics. We systematically screened 8982 sequenced genomes from 42 bacterial genera and identified eight potential CLP biosynthetic gene clusters. Their predicted products were rapidly accessed by solid-phase total synthesis, which led the novel antibiotic chospeptin with...
Menaquinone (MK) in bacterial membrane is an attractive target for the development of novel therapeutic agents. Mining untapped chemical diversity encoded by Gram-negative bacteria presents opportunity to identify additional MK-binding antibiotics (MBAs). By motif searching bioinformatically predicted linear non-ribosomal peptides from 14,298 sequenced genomes 45 underexplored genera, here we a MBA structural family, including silvmeb and pseudomeb, using structure prediction-guided...
Open AccessCCS ChemistryRESEARCH ARTICLES10 Dec 2024Discovery of a novel family Gram-negative-active cationic cyclolipopeptides by motif search-guided chemical synthesis Fan Zhang, Fei Xuchang Yu, Runze Sun, Yuzhu Wu, Yiwen Zhou and Lei Li Zhang , Yu Sun Wu https://doi.org/10.31635/ccschem.024.202404925 SectionsSupplemental MaterialAboutPDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookTwitterLinked InEmail Emerging antimicrobial resistance is global public health...
Bohemamines (BHMs) are bacterial alkaloids containing a pyrrolizidine core with two unprecedented methyl groups. Herein we report the activation of BHMs biosynthesis in Streptomyces sp. CB02009 using ribosome engineering approach. Identification and characterization bhm gene cluster reveals coordinated action nonribosomal peptide synthetase BhmJ, Baeyer-villiger monooxygenase BhmK methyltransferase BhmG for biosynthesis. is responsible C-methylation on C-7, while C-9 group from...
Yangpumicins (YPMs), eg. YPM A, F, and G, are newly discovered enediynes from Micromonospora yangpuensis DSM 45577, which could be exploited as promising payloads of antibody-drug conjugates. However, the low yield YPMs in wild-type strain (~1 mg/L) significantly hampers their further drug development. In this study, a combined ribosome engineering fermentation optimization strategy has been used for improvement YPMs. One gentamycin-resistant M. 45577 (MY-G-1) showed higher production (7.4 ±...