A5077583789- Peroxisome Proliferator-Activated Receptors
- Amino Acid Enzymes and Metabolism
- Immune Cell Function and Interaction
- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer, Hypoxia, and Metabolism
- T-cell and B-cell Immunology
- Diabetes and associated disorders
- Urticaria and Related Conditions
- Metabolism, Diabetes, and Cancer
- Biomedical Research and Pathophysiology
- Platelet Disorders and Treatments
- Advanced Glycation End Products research
- Allergic Rhinitis and Sensitization
- Mast cells and histamine
- Sulfur Compounds in Biology
- Cholesterol and Lipid Metabolism
- Monoclonal and Polyclonal Antibodies Research
- IL-33, ST2, and ILC Pathways
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammatory mediators and NSAID effects
- Asthma and respiratory diseases
University of Bern
2019-2024
University Hospital of Bern
2019-2024
Abstract T helper 9 (T H 9) cells promote allergic tissue inflammation and express the type 2 cytokines, IL-9 IL-13, as well transcription factor, PPAR-γ. However, functional role of PPAR-γ in human remains unknown. Here, we demonstrate that drives activation-induced glycolysis, which, turn, promotes expression IL-9, but not an mTORC1-dependent manner. In vitro ex vivo experiments show PPAR-γ-mTORC1-IL-9 pathway is active skin inflammation. Additionally, find dynamic regulation glucose...
Aim of the projectTo ultimate aim project is to develop sensitive and quantitative assays detect Abs against A2ML1 extend them for diagnosis more common autoimmune skin diseases by expressing relevant EGFP-tagged antigens.The availability novel diagnostic tools with high specificity sensitivity important ensure correct classification affected patients, proper disease management their prognosis.
Abstract T helper 9 cells (T H 9) are key drivers of allergic tissue inflammation. They characterized by the expression type 2 cytokines, such as IL-9 and IL-13, peroxisome proliferator-activated receptor gamma (PPAR-γ) transcription factor. However, functional role PPAR-γ in human remains unknown. Here, we demonstrate that drives activation-induced glycolysis, which, turn, specifically promotes IL-9, but not an mTORC1-dependent manner. In vitro ex vivo experiments on skin samples contact...