A5067196942- Receptor Mechanisms and Signaling
- Monoclonal and Polyclonal Antibodies Research
- S100 Proteins and Annexins
- Microbial Metabolism and Applications
- Cancer Immunotherapy and Biomarkers
- Plant-based Medicinal Research
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Acupuncture Treatment Research Studies
- Esophageal Cancer Research and Treatment
- HER2/EGFR in Cancer Research
- Neuropeptides and Animal Physiology
- Colorectal Cancer Treatments and Studies
- Computational Drug Discovery Methods
- Barrier Structure and Function Studies
- Anorectal Disease Treatments and Outcomes
- Glycosylation and Glycoproteins Research
- Renin-Angiotensin System Studies
- Metastasis and carcinoma case studies
Columbia University Irving Medical Center
2020-2021
Columbia University
2019
National Center on Addiction and Substance Abuse at Columbia University
2019
IDEX Corporation (United States)
2013
DiscoveRx (United States)
2012
Yale University
2006
Baxter (United States)
2006
Stanford University
2006
A variety of G-protein–coupled receptor (GPCR) screening technologies have successfully partnered a number GPCRs with their cognate ligands. GPCR-mediated β-arrestin recruitment is now recognized as distinct intracellular signaling pathway, and ligand-receptor interactions may show bias toward over classical GPCR pathways. We hypothesized that the failure to identify native ligands for remaining orphan be consequence biased signaling. To investigate this, we assembled 10 500 candidate...
The orphan receptor tyrosine kinase ErbB2 is activated by each of the EGFR family members upon ligand binding. However, difficulties monitoring dynamic interactions membrane receptors have hindered elucidation mechanism activation. We engineered a system to monitor protein-protein in intact mammalian cells such that different sets protein can be quantitatively compared. Application this showed interacts stably with and ErbB3, but fails spontaneously homooligomerize. widely used anti-cancer...
Abstract Colorectal cancer (CRC) is the second leading cause of death in U.S., affecting one 20 individuals. Numerous studies have implicated Fusobacterium nucleatum (Fn), a Gram-negative oral commensal, CRC; however, mechanistic insight on role Fn this debilitating disease scarce. Previously, we reported that stimulates CRC growth through its unique adhesin FadA, which binds to E-cadherin and modulates β-catenin signaling. In present study, tested specificity Fn-induced cell growth. did not...
Colorectal cancer (CRC) is the second leading cause of death in U.S., affecting one 20 individuals. Numerous studies have implicated Fusobacterium nucleatum (Fn), a Gram-negative oral commensal, CRC; however, mechanistic insight on role Fn this debilitating disease scarce.Previously, we reported that stimulates CRC growth through its unique adhesin FadA, which binds to E-cadherin and modulates β-catenin signaling. In present study, tested specificity Fn-induced cell growth. did not promote...