A5085628244- Skin and Cellular Biology Research
- Autoimmune Bullous Skin Diseases
- Dermatological and Skeletal Disorders
- Metabolism and Genetic Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Cardiac Arrhythmias and Treatments
- Hair Growth and Disorders
- Cell Adhesion Molecules Research
- Plant Reproductive Biology
- Nail Diseases and Treatments
- RNA Research and Splicing
- Adrenal Hormones and Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- RNA and protein synthesis mechanisms
- Genetic and rare skin diseases.
- Connective tissue disorders research
- melanin and skin pigmentation
- RNA Interference and Gene Delivery
- Biochemical and Molecular Research
- Skin Diseases and Diabetes
- Eosinophilic Disorders and Syndromes
- Liver Disease Diagnosis and Treatment
- Erythrocyte Function and Pathophysiology
- Oral Health Pathology and Treatment
Unfallkrankenhaus Salzburg
2001-2024
University of Salzburg
2008-2021
Paracelsus Medical University
2009-2020
Paracelsus Medizinische Privatuniversität
2008-2020
Medical University of Vienna
2005-2016
EB House Austria
2007-2016
Debra
2016
Austrian Society of Dermatology and Venereology
2016
Universitätskliniken Salzburg
2016
Universität Innsbruck
1983-2015
• Eight cases of a new variant hereditary epidermolysis bullosa (EB), generalized atrophic benign EB, are reported. This is junctional form EB that, in contrast to letalis Herlitz, has good prognosis. It inherited as an autosomal recessive trait, and the clinical picture monotonously similar all patients observed so far, with blister formation, alopecia, dystrophic nail changes. Blisters on skin mucous membranes heal without scarring or dystrophy but often result notable atrophy. There...
True hyphal growth of Candida albicans can be induced by several environmental conditions and contributes significantly to the high virulence this pathogenic fungus. The transcriptional network that governs morphogenesis is complex, depends on regulators not completely understood. Recently, CaUME6, a homolog Saccharomyces cerevisiae UME6 gene, has been shown required for elongation. In present study, C. ume6Delta strain showed complete defect in hyphae formation under all tested. was...
The monoclonal antibody, KF-1, identifies a noncollagenous constituent of the lamina densa basement membrane zone (BMZ) skin. In order to determine whether this BMZ is affected in epidermolysis bullosa (EB), mechanobullous skin disease often resulting marked disfigurement, we have examined from patients with various forms for binding by KF-1 as well polyclonal antibodies laminin, type IV collagen, and bullous pemphigoid antigen, three other known components normal all specimens simplex...
Serum amyloid P component (SAP) is the single plasma protein that, from milieu of whole normal human serum, undergoes specific calcium-dependent binding to isolated DNA and chromatin in vitro. We now report for first time that SAP serum also nuclei epidermal cells sections skin fixed Hep-2 cells, a epithelial cell line. Furthermore, most importantly, was detected association with unusual globular dermal deposits nuclear material biopsies two patients systemic lupus erythematosus. This...
The major challenge to a successful gene therapy of autosomal dominant genetic diseases is highly efficient and specific knock-down or repair the disease-causing allele. In epidermolysis bullosa simplex-type Dowling–Meara (EBS-DM), single amino acid exchange in exon 1 keratin 14 (K14) triggers severe skin phenotype, characterized by blistering mucous membranes after minor trauma. We chose spliceosome-mediated RNA trans-splicing specifically replace exons 1–7 K14 gene. this approach, mutated...
We report here on three patients suffering from recessive dystrophic epidermolysis bullosa and one generalized atrophic benign bullosa, all of whom developed cutaneous squamous cell carcinoma. Our observations a review the literature suggest that carcinoma in is very infrequent has better outcome compared to skin cancer bullosa. These differences could be explained by distinct pathophysiology clinical course each these variants In contrast UV-induced cancer, tumours develop distal...