A5075644830- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Tryptophan and brain disorders
- Colorectal Cancer Screening and Detection
- Cancer Risks and Factors
- Biochemical Acid Research Studies
- Diet and metabolism studies
- Women's cancer prevention and management
- Genetic factors in colorectal cancer
- Cancer-related Molecular Pathways
- Breast Cancer Treatment Studies
- Neuroblastoma Research and Treatments
- Colorectal and Anal Carcinomas
- Pharmacological Receptor Mechanisms and Effects
The University of Texas Southwestern Medical Center
2024
Pontifícia Universidade Católica de Goiás
2019-2021
Abstract Cancer cells exhibit distinct metabolic activities and nutritional dependencies compared to normal cells. Thus, characterization of nutrient demands by individual tumor types may identify specific vulnerabilities that can be manipulated target the destruction cancer We find MYC-driven liver tumors rely on augmented tryptophan (Trp) uptake, yet Trp utilization generate metabolites in kynurenine (Kyn) pathway is reduced. Depriving through a No-Trp diet not only prevents growth but...
Neuroblastoma poses significant challenges in clinical management. Despite its relatively low incidence, this malignancy contributes disproportionately to cancer‐related childhood mortality. Tailoring treatments based on risk stratification, including MYCN oncogene amplification, remains crucial, yet high‐risk cases often confront therapeutic resistance and relapse. Here, we explore the aryl hydrocarbon receptor (AHR), a versatile transcription factor implicated diverse physiological...
Human papillomavirus (HPV) infection is associated with the development of anogenital and head neck cancers. In recent years a potential role HPV in colorectal cancer (CRC) has been suggested.To investigate presence carcinomas to study p16INK4a as marker transcriptionally active infection. addition, correlation between these findings CRC prognostic factors.Case control 92 cases cancers, 75 controls normal tissue adjacent tumor, 30 precursor lesions, including polyps adenomas. Paraffinized...
Objective: The aim of this study was to investigate the frequency R337H variant in TP53 gene a group premenopausal women with breast cancer from central-western region Brazil and its possible associations clinical, pathological, prognostic aspects. Methods: research comprised pilot 36 patients carcinomas diagnosed before age 50, selected records Laboratory Immunohistochemistry, Department Pathology, Hospital Araújo Jorge, Goiânia (GO). DNA extraction performed QIAamp FFPE Advanced (Qiagen,...
Objective: The aim of this study was to investigate the clinical-pathological features and prognosis premenopausal breast cancer patients, stratified by three age groups (below 33 years, 34–36 37–49 years). Methods: This is a retrospective including 206 patients with carcinomas diagnosed before 50 selected from records Laboratory Immunohistochemistry, Department Pathology, Hospital Araújo Jorge, in Goiânia (GO). Results: Patients’ at diagnosis ranged 21 49 mean 34 years (±4.3). 5-year...