A5087270959- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neural Engineering
- Genetics and Neurodevelopmental Disorders
- Down syndrome and intellectual disability research
- EEG and Brain-Computer Interfaces
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Sleep and Wakefulness Research
- Conducting polymers and applications
- Photochromic and Fluorescence Chemistry
- Olfactory and Sensory Function Studies
- Microbial Inactivation Methods
- Autism Spectrum Disorder Research
- Genetic Neurodegenerative Diseases
- Nicotinic Acetylcholine Receptors Study
- Retinal Development and Disorders
- stochastic dynamics and bifurcation
- Biochemical Analysis and Sensing Techniques
- Zebrafish Biomedical Research Applications
- Connective tissue disorders research
- Tryptophan and brain disorders
Institut Català de Nanociència i Nanotecnologia
2022-2024
Hospital del Mar Research Institute
2015-2023
Barcelona Biomedical Research Park
2014-2023
Universitat Autònoma de Barcelona
2022-2023
Hospital Del Mar
2018-2022
Centro de Investigación Biomédica en Red
2022
Biomedical Research Networking Center on Neurodegenerative Diseases
2022
Municipal Institute for Medical Research
2018
Centre for Genomic Regulation
2014-2016
Universitat Pompeu Fabra
2016
Abstract One of the critical factors determining performance neural interfaces is electrode material used to establish electrical communication with tissue, which needs meet strict electrical, electrochemical, mechanical, biological and microfabrication compatibility requirements. This work presents a nanoporous graphene-based thin-film technology its engineering form flexible interfaces. The developed allows fabrication small microelectrodes (25 µm diameter) while achieving low impedance...
Down syndrome (DS) is the most common form of intellectual disability. The cognitive alterations in DS are thought to depend on brain regions critical for learning and memory such as prefrontal cortex (PFC) hippocampus (HPC). Neuroimaging studies suggest that increased connectivity correlates with lower intelligence quotients (IQ) individuals DS; however, its contribution impairment unresolved. We recorded neural activity PFC HPC trisomic Ts65Dn mouse model during quiet wakefulness, natural...
The dual-specificity tyrosine phosphorylation-regulated kinase DYRK1A is a serine/threonine involved in neuronal differentiation and synaptic plasticity major candidate of Down syndrome brain alterations cognitive deficits. strongly expressed the cerebral cortex, its overexpression leads to defective cortical pyramidal cell morphology, deficits, altered excitation/inhibition balance. These previous observations, however, do not allow predicting how behavior prefrontal cortex (PFC) network...
Neural correlates of spatial representation can be found in the activity hippocampal place cells. These neurons are characterized by firing whenever animal is located a particular area space, field. Place fields modulated sensory cues, such as visual, auditory, or olfactory being influence visual inputs most thoroughly studied. Tactile information gathered whiskers has prominent rat cerebral cortex. However, whisker-detected tactile cues on remains an open question. Here we studied enriched...
We investigated the cellular and neurophysiological mechanisms underlying pro-cognitive effects of 5-HT4R activation in hippocampal-prefrontal pathways. Our findings show that, addition to pyramidal neurons, 30–60% parvalbumin+ interneurons CA1, CA3, dentate gyrus (DG) hippocampus anterior cingulate (ACC), prelimbic (PL), infralimbic (IL) regions prefrontal cortex co-express 5-HT4Rs. Additionally, 15% somatostatin+ CA1 CA3 express The partial agonist RS-67333 (1 mg/kg, i.p.) exerted...
Brain-computer interfaces (BCI) are using the electroencephalogram, electrocorticogram and trains of action potentials as inputs to analyze brain activity for communication purposes and/or control external devices. Thus far it is not known whether a BCI system can be developed that utilizes states structures situated well below cortical surface, such hippocampus. In order address this question we used hippocampal place cells (PCs) predict position an rodent in real-time. First, spike was...
Abstract Myotonic dystrophy type 1 (DM1) is a multisystem disorder affecting muscle and central nervous system (CNS) function. The cellular mechanisms underlying CNS alterations are poorly understood no useful treatments exist for the neuropsychological deficits observed in DM1 patients. We investigated progression of behavioral present male female muscleblind-like 2 (Mbnl2) knockout (KO) mice, rodent model DM1, determined biochemical electrophysiological correlates medial prefrontal cortex...
Neural synchrony and functional connectivity are disrupted in schizophrenia. We investigated changes prefrontal-hippocampal neural dynamics during psychosis-like states induced by the NMDAR antagonist phencyclidine subsequent rescue two atypical antipsychotic drugs (AAPDs), risperidone clozapine, classical APD haloperidol. The psychotomimetic effects of were associated with prefrontal hypersynchronization, hippocampal desynchronization, circuit connectivity. Phencyclidine boosted oscillatory...
Understanding the dopaminergic system is a priority in neurobiology and neuropharmacology. Dopamine receptors are involved modulation of fundamental physiological functions, dysregulation transmission associated with major neurological disorders. However, available tools to dissect endogenous circuits have limited specificity, reversibility, resolution, or require genetic manipulation. Here, we introduce azodopa, novel photoswitchable ligand that enables reversible spatiotemporal control...
Whole-cell patch recording is an essential tool for quantitatively establishing the biophysics of brain function, particularly in vivo. This method particular interest studying functional roles cortical glial cells intact brain, which cannot be assessed with extracellular recordings. Nevertheless, a reasonable success rate remains challenge because stability, duration and electrical quality constraints, voltage clamp, dynamic clamp or conductance measurements. To address this, we describe...
N-methyl D-aspartate receptor (NMDAR) hypofunction is a pathophysiological mechanism relevant for schizophrenia. Acute administration of the NMDAR antagonist phencyclidine (PCP) induces psychosis in patients and animals while subchronic PCP (sPCP) produces cognitive dysfunction weeks. We investigated neural correlates memory auditory impairments mice treated with sPCP rescuing abilities atypical antipsychotic drug risperidone administered daily two recorded activities medial prefrontal...
Addiction involves long-lasting maladaptive changes including development of disruptive drug-stimuli associations. Nicotine-induced neuroplasticity underlies the tobacco addiction but also, in regions such as hippocampus, ability this drug to enhance cognitive capabilities. Here, we propose that genetic locus susceptibility nicotine addiction, CHRNA5/A3/B4 gene cluster, encoding α5, α3 and β4 subunits nicotinic acetylcholine receptors (nAChRs), may influence nicotine-induced...
Stimulating lifestyles have powerful effects on cognitive abilities, especially when they are experienced early in life. Cognitive therapies widely used to improve impairment due intellectual disability, aging, and neurodegeneration, however the underlying neural mechanisms poorly understood. We investigated correlates of memory amelioration produced by postnatal environmental enrichment (EE) diploid mice Ts65Dn mouse model Down syndrome (trisomy 21). recorded activities brain structures key...
In this study, we investigated the impact of Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A) overexpression, a gene associated with Down syndrome, on hippocampal neuronal deficits in mice. Our findings revealed that mice overexpressing Dyrk1A (TgDyrk1A; TG) exhibited impaired recognition memory, disrupted excitation-inhibition balance, and long-term potentiation (LTP). Specifically, observed layer-specific dendritic arborization TG CA1 pyramidal neurons stratum...
Understanding the dopaminergic system is a priority in neurobiology and neuropharmacology. Dopamine receptors are involved modulation of fundamental physiological functions dysregulation transmission associated with major neurological disorders. However, available tools to dissect endogenous circuits have limited specificity, reversibility, resolution, or require genetic manipulation. Here we introduce azodopa, novel photoswitchable ligand that enables reversible spatiotemporal control...
ABSTRACT Neural synchrony and functional connectivity are disrupted in neuropsychiatric disorders such as schizophrenia. However, these alterations how they affected by commonly prescribed medication have not been characterized depth. Here, we investigated changes neural dynamics of circuits involving the prefrontal cortex hippocampus during psychosis induced NMDAR antagonist phencyclidine subsequent recovery three different antipsychotic drugs (APDs), classical APD haloperidol two atypical...
ABSTRACT NMDAR hypofunction is a pathophysiological mechanism relevant for schizophrenia. Acute administration of the antagonist phencyclidine (PCP) induces psychosis in patients and animals while subchronic PCP (sPCP) produces cognitive dysfunction weeks. We investigated neural correlates memory perceptual impairments mice treated with sPCP rescuing abilities atypical antipsychotic drug risperidone administered daily two recorded activities medial prefrontal cortex (mPFC) dorsal hippocampus...