A5060276989- Neuroscience and Neural Engineering
- Muscle activation and electromyography studies
- Conducting polymers and applications
- Nerve injury and regeneration
- EEG and Brain-Computer Interfaces
- Mesenchymal stem cell research
- Muscle Physiology and Disorders
- Advanced Memory and Neural Computing
- Neurogenesis and neuroplasticity mechanisms
- Lipid Membrane Structure and Behavior
- Wound Healing and Treatments
- Neural dynamics and brain function
- Signaling Pathways in Disease
- Nerve Injury and Rehabilitation
- Pain Mechanisms and Treatments
- Neurogenetic and Muscular Disorders Research
- Transcranial Magnetic Stimulation Studies
- Axon Guidance and Neuronal Signaling
- Spinal Cord Injury Research
- Knee injuries and reconstruction techniques
Centro de Investigación Biomédica en Red
2017-2024
Biomedical Research Networking Center on Neurodegenerative Diseases
2017-2024
Universitat Autònoma de Barcelona
2015-2024
University of Miami
2021
Neurological Surgery
2021
Instituto de Salud Carlos III
2019
Abstract One of the critical factors determining performance neural interfaces is electrode material used to establish electrical communication with tissue, which needs meet strict electrical, electrochemical, mechanical, biological and microfabrication compatibility requirements. This work presents a nanoporous graphene-based thin-film technology its engineering form flexible interfaces. The developed allows fabrication small microelectrodes (25 µm diameter) while achieving low impedance...
Abstract Parylene C is a highly flexible polymer used in several biomedical implants. Since previous studies have reported valuable biocompatible and manufacturing characteristics for brain intraneural implants, we tested its suitability as substrate peripheral nerve electrodes. We evaluated 1-year-aged vitro samples, where no chemical differences were observed only slight deviation on Young’s modulus was found. The foreign body reaction (FBR) to longitudinal devices implanted the rat...
Abstract The foreign body reaction (FBR) against an implanted device is characterized by the formation of a fibrotic tissue around implant. In case interfaces for peripheral nerves, used to stimulate specific group axons and record different nerve signals, FBR induces matrix deposition implant creating physical separation between fibers interface that may reduce its functionality over time. order understand how intraneural evolves, polyimide non‐functional devices were in rat nerve....
Duchenne muscle dystrophy (DMD) is a genetic disorder characterized by progressive skeletal weakness. Dystrophin deficiency induces instability of the sarcolemma during contraction that leads to necrosis and replacement fibro-adipose tissue. Several therapies have been developed counteract fibrotic process. We report effects nintedanib, tyrosine kinase inhibitor, in mdx murine model DMD. Nintedanib reduced proliferation migration human fibroblasts vitro decreased expression genes such as...
Axonal growth during normal development and axonal regeneration rely on the action of many receptor signaling systems complexes, most them located in specialized raft membrane microdomains with a precise lipid composition. Cholesterol is component rafts, integrity these structures depends concentrations present this compound. Here we explored effect cholesterol depletion both developing neurons regenerating axons. First, show that vitro from central peripheral nervous increases size cones,...
For assessing the suitability of a given material for peripheral nerve implantation, acute and chronic tests to investigate tissue reaction, evaluate thickness fibroblast layers that surround presence inflammatory cells are mandatory. In this study we compared in vivo biocompatibility parylene C polyimide, two materials intended fabrication neural electrodes. We have tested these after implantation thin devices rats, by functional morphological methods, fibrotic capsule, signs inflammation...
The current clinical standard of harvesting a nerve autograft for repair long-segment peripheral injuries (PNIs) is associated with many potential complications. Guidance channels offer an alternative therapy. authors investigate whether autologous Schwann cells (SCs) implanted within novel collagen-glycosaminoglycan conduit will improve axonal regeneration in PNI model.
ABSTRACT Intraneural electrodes must be in intimate contact with nerve fibers to have a proper function, but this interface is compromised due the foreign body reaction (FBR). The FBR characterized by first inflammatory phase followed second anti‐inflammatory and fibrotic phase, which results formation of tissue capsule around implant, causing physical separation between active sites electrode fibers. We tested systemically several drugs such as dexamethasone (subcutaneous), ibuprofen...
Neuroprostheses aimed to restore lost functions after a limb amputation are based on the interaction with nervous system by means of neural interfaces. Among different designs, intraneural electrodes implanted in peripheral nerves represent good strategy stimulate nerve fibers send sensory feedback and record signals control prosthetic limb. However, electrodes, as any device body, induce foreign body reaction (FBR) that results tissue encapsulation device. The FBR causes progressive decline...
Interfacing the peripheral nervous system can be performed with a large variety of electrode arrays. However, stimulating and recording nerve while having reasonable amount channels limits number available systems. Translational research towards human clinical trial requires device safety biocompatibility but would benefit from design flexibility in development process to individualize probes.We selected established medical grade implant materials like precious metals Parylene C develop...
Mesenchymal stromal cells (MSC) are used for cell therapy spinal cord injury (SCI) because of their ability to support tissue repair by paracrine signaling. Preclinical and clinical research testing MSC transplants SCI have revealed limited success, which warrants the exploration strategies improve therapeutic efficacy. sensitive microenvironment secretome can be altered in vitro exposure different culture media. Priming with inflammatory stimuli increases expression secretion reparative...
The foreign body reaction is a complex biological process leading to the insulation of implanted artificial materials through capsule scar tissue. In particular, in chronic implantations neural electrodes, prediction tissue evolution crucial assess implant reliability over time. Indeed, behaves like an increasing insulating barrier between electrodes and nerve fibers. However, no explicit physically based rules are available computationally reproduce evolution. addition, standard approaches...
Segregation of regenerating motor and sensory axons may be a good strategy to improve selective functionality regenerative interfaces provide closed-loop commands. Provided that extracellular matrix components neurotrophic factors exert guidance effects on different neuronal populations, we assessed in vivo the potential separating bicompartmental Y-type tube, with each branch prefilled an adequate combination factors. The severed rat sciatic nerve was repaired using tube filled collagen...
A biomedical interface that combines into a single and compact device the recording of biopotentials electrical stimulation neural fibres is presented. It intended for enabling control over robotic hand restoring sensory feedback in amputees by directly interfacing peripheral nervous system (PNS) closed-loop. modular consisting one or more independent 16-channels bidirectional units was conceived. Each module based on three 0.35µm bulk-CMOS integrated circuits (ICs): unit, High-Voltage (HV)...
Abstract Neuroprosthetic technology aims to restore nervous system functionality in cases of severe damage or degeneration by recording and stimulating the electrical activity neural tissue. One key factors determining quality neuroprostheses is electrode material used establish communication with tissue, which subject strict electrical, electrochemical, mechanical specifications as well biological microfabrication compatibility requirements. This work presents a nanoporous graphene-based...