A5027845505- Bone Tissue Engineering Materials
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- 3D Printing in Biomedical Research
- Vitamin C and Antioxidants Research
- Titanium Alloys Microstructure and Properties
- Bone and Dental Protein Studies
- Silk-based biomaterials and applications
- Tryptophan and brain disorders
- Oral and Maxillofacial Pathology
- Paraoxonase enzyme and polymorphisms
- Alzheimer's disease research and treatments
- Pesticide Exposure and Toxicity
- dental development and anomalies
- Dental Implant Techniques and Outcomes
- Additive Manufacturing and 3D Printing Technologies
- Neuroinflammation and Neurodegeneration Mechanisms
University of Iowa
2017-2024
In addition to cognitive deficits, Alzheimer's disease (AD) is associated with other neuropsychiatric symptoms, including severe depression. Indeed, depression often precedes deficits in patients AD. Unfortunately, the field has seen only minimal therapeutic advances, underscoring critical need for new treatments. P7C3 aminopropyl carbazoles promote neuronal survival by enhancing nicotinamide adenine dinucleotide flux injured neurons. Neuroprotection compounds been demonstrated preclinical...
Occupational exposure to organophosphate pesticides, such as chlorpyrifos (CPF), increases the risk of Alzheimer's disease (AD), though mechanism is unclear. To investigate this, we subjected 4-month-old male and female wild-type (WT) TgF344-AD rats, a transgenic AD model, an occupational CPF paradigm that recapitulates biomarkers behavioral impairments experienced by agricultural workers. Subsequent cognition neuropathology were analyzed over next 20 months. caused chronic microglial...
The fabrication of clinically relevant synthetic bone grafts relies on combining multiple biodegradable biomaterials to create a structure that supports the regeneration defects while delivering osteogenic biomolecules enhance regeneration. MicroRNA-200c (miR-200c) functions as potent osteoinductive biomolecule differentiation and formation; however, tissue-engineered sustain delivery miR-200c for have not yet been evaluated. In this study, we created novel, multimaterial, from...
Advanced fabrication methods for bone grafts designed to match defect sites that combine biodegradable, osteoconductive materials with potent, osteoinductive biologics would significantly impact the clinical treatment of large defects. In this study, we engineered synthetic using a hybrid approach combined three-dimensional (3D-)printed β-tricalcium phosphate (β-TCP) microRNA(miR)-200c. 3D-printed β-TCP scaffolds were fabricated utilizing suspension-enclosing projection-stereolithography...
MicroRNA (miR)–200c suppresses the initiation and progression of oral squamous cell carcinoma (OSCC), most prevalent head neck cancer with high recurrence, metastasis, mortality rates. However, miR-200c–based gene therapy to inhibit OSCC growth has yet be reported. To develop an miR-based improve outcomes treatment, this study investigates feasibility plasmid DNA (pDNA) encoding miR-200c delivered via nonviral CaCO 3 -based nanoparticles tumor growth. various ratios protamine sulfate (PS)...
Aim: miRNAs have been shown to improve the restoration of craniofacial bone defects. This work aimed enhance transfection efficiency and miR-200c-induced formation in alveolar defects via plasmid DNA encoding miR-200c delivery from CaCO3 nanoparticles. Materials & methods: The CaCO3/miR-200c system was evaluated vitro (microscopy, efficiency, biocompatibility) vivo assessed micro-computed tomography histology. Results: nanoparticles significantly enhanced without inflammatory effects...
Coordinated mineralization of soft tissue is central to organismal form and function, while dysregulated underlies several human pathologies. Oral epithelial–derived ameloblasts are polarized, secretory cells responsible for generating enamel, the most mineralized substance in body. Defects ameloblast development result enamel anomalies, including amelogenesis imperfecta. Identifying proteins critical can provide insight into specific pathologies associated with enamel-related disorders or,...
Abstract MicroRNA (miR)-200c suppresses the initiation and progression of oral squamous cell carcinoma (OSCC), most prevalent head neck cancer with high recurrence, metastasis, mortality rates. However, miR-200c -based gene therapy to inhibit OSCC growth metastasis has yet be reported. To develop an miR-based improve outcomes treatment, this study investigates feasibility plasmid DNA encoding delivered via non-viral CaCO 3 nanoparticles tumor growth. various ratios protamine sulfate (PS)...
Advanced fabrication methods of bone grafts designed to match defect sites that combine biodegradable, osteoconductive materials with potent, osteoinductive biologics would significantly impact the clinical treatment large defects. In this study, we engineered synthetic using a hybrid material approach combined 3D-printed β-tricalcium phosphate (β-TCP) microRNA(miR)-200c. β-TCP scaffolds were fabricated utilizing suspension-enclosing projection-stereolithography (SEPS) process produce...