A5101771048- Microbial Metabolic Engineering and Bioproduction
- Gene expression and cancer classification
- Gene Regulatory Network Analysis
- Biofuel production and bioconversion
- Algal biology and biofuel production
- Photosynthetic Processes and Mechanisms
- Enzyme Catalysis and Immobilization
- Viral Infectious Diseases and Gene Expression in Insects
- Bioinformatics and Genomic Networks
- Neural Networks and Applications
- Fuzzy Logic and Control Systems
- Spectroscopy and Chemometric Analyses
- vaccines and immunoinformatics approaches
- Water Quality Monitoring and Analysis
- EEG and Brain-Computer Interfaces
- Microtubule and mitosis dynamics
- Food Quality and Safety Studies
- Bacterial Genetics and Biotechnology
- Cancer-related Molecular Pathways
- Sensory Analysis and Statistical Methods
- Evolutionary Algorithms and Applications
- Immunotherapy and Immune Responses
- Advanced Chemical Sensor Technologies
- Neurological Disease Mechanisms and Treatments
- Advanced Control Systems Optimization
Kyushu University
2013-2023
Bioengineering Center
2017
National Center for Genetic Engineering and Biotechnology
2017
John Wiley & Sons (United States)
2017
Center for Systems Biology
2011-2016
University of California, Los Angeles
2007
Nagoya University
1986-2004
Pfizer (Japan)
2002
The University of Tokyo
1994
Tohoku University
1992
ABSTRACT A synthetic pathway was engineered in Escherichia coli to produce isopropanol by expressing various combinations of genes from Clostridium acetobutylicum ATCC 824, E. K-12 MG1655, beijerinckii NRRL B593, and Thermoanaerobacter brockii HTD4. The strain with the combination C. thl (acetyl-coenzyme [CoA] acetyltransferase), atoAD (acetoacetyl-CoA transferase), adc (acetoacetate decarboxylase), adh (secondary alcohol dehydrogenase) achieved highest titer. This produced 81.6 mM shake...
It is well understood that the successful clustering of expression profiles give beneficial ideas to understand functions uncharacterized genes. In order realize such a clustering, we investigate method based on adaptive resonance theory (ART) in this report.We apply Fuzzy ART as for analyzing time series data during sporulation Saccharomyces cerevisiae. The result by was compared with those other methods hierarchical k-means algorithm and self-organizing maps (SOMs). terms mathematical...
Production directly from carbon dioxide by engineered cyanobacteria is one of the promising technologies for sustainable future. Previously, we have successfully achieved 1,3-propanediol (1,3-PDO) production using Synechococcus elongatus PCC 7942 with a synthetic metabolic pathway. The strain into which pathway was introduced produced 3.48 mM (0.265 g/L) 1,3-PDO and 14.3 (1.32 glycerol during 20 days incubation. In this study, productivities were improved gene disruption selected screening...
Diffuse large B‐cell lymphoma (DLBCL) is the largest category of aggressive lymphomas. Less than 50% patients can be cured by combination chemotherapy. Microarray technologies have recently shown that response to chemotherapy reflects molecular heterogeneity in DLBCL. On basis published microarray data, we attempted develop a long‐overdue method for precise and simple prediction survival DLBCL patients. We developed fuzzy neural network (FNN) model analyze gene expression profiling data From...
3-hydroxypropionic acid (3-HP) is an important platform for the production of C3 chemicals, including acrylic acid, methyl acrylate, and acrylamide. Microbial 3-HP mainly due to glycerol metabolism. In this study, in order improve microbial production, we applied a metabolic toggle switch controlling metabolism redirect excess flux central pathway toward exogenous producing Escherichia coli. The enables conditional repression expression target gene during fermentation. We individually...