A5101832419- Chronic Obstructive Pulmonary Disease (COPD) Research
- Radiomics and Machine Learning in Medical Imaging
- Appendicitis Diagnosis and Management
- Respiratory Support and Mechanisms
- Intraperitoneal and Appendiceal Malignancies
- Cystic Fibrosis Research Advances
- Lung Cancer Treatments and Mutations
- Transplantation: Methods and Outcomes
- Ovarian cancer diagnosis and treatment
- Tuberculosis Research and Epidemiology
- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Tracheal and airway disorders
- Minimally Invasive Surgical Techniques
- Respiratory viral infections research
- Acute Lymphoblastic Leukemia research
- Mycobacterium research and diagnosis
- Obstructive Sleep Apnea Research
- Acute Myeloid Leukemia Research
- Endometrial and Cervical Cancer Treatments
- Childhood Cancer Survivors' Quality of Life
- Renal Transplantation Outcomes and Treatments
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Ureteral procedures and complications
John Radcliffe Hospital
2024
University of Oxford
2024
Oxford University Hospitals NHS Trust
2022-2023
Auckland City Hospital
2011-2022
Henry Ford Hospital
2022
Great North Children's Hospital
2022
London Cancer
2016-2021
London School of Hygiene & Tropical Medicine
2016-2021
Jackson Memorial Hospital
2019
University of Auckland
2003-2018
Although bronchiectasis has become a rare condition in U.S. children, it is still commonly diagnosed Alaska Native children the Yukon Kuskokwim Delta. The prevalence of not decreased persons born during 1980s as compared with those 1940s. We reviewed case histories 46 bronchiectasis. observed that recurrent pneumonia was major preceding medical 85% patients. There an association between lobes affected by and Eight (17%) patients had surgical resection involved lobes. conclude continued high...
<h3>Background and aims:</h3> The clinical impact of nocturnal desaturation on health related quality life (HRQL) sleep in chronic obstructive pulmonary disease (COPD) has been little studied. aim this study was to evaluate the prevalence a typical outpatient population with COPD. <h3>Patients methods:</h3> Between 2002 2005, consecutive patients COPD attending services at centre underwent resting oximetry if they were not domiciliary oxygen therapy. If their saturations less than 95%,...
Recently, Mycobacterium tuberculosis isolates have been described that test phenotypically susceptible to rifampicin (RMP) yet harbour genotypic rpoB mutations.1) To investigate the impact of such mutations on clinical outcomes among RMP-susceptible isolates, and 2) determine prevalence isoniazid (INH) monoresistant at our laboratory describe association between presence these outcomes.M. were screened for in gene using Cepheid Gene-Xpert® MTB/RIF assay. Clinical correlation was made by...
The COVID-19 pandemic is having a deep impact on emergency surgical services, with significant reduction of patients admitted into units world widely. Reliable figures this have not been produced yet. Our international audit aimed at giving precise snapshot the absolute and relative changes admissions outbreak pandemic.Datasets as general emergencies 45 internationally distributed during months March April 2020 (Covid-19 outbreak) were collected compared those same 2019 (pre-Covid-19)....
Shortburst oxygen therapy (SBOT) remains an unproven treatment for reduction of exertional dyspnoea in chronic obstructive pulmonary disease (COPD). This study aimed to assess whether SBOT before exercise reduces or improves performance, and after during recovery. Twentytwo clinically stable COPD patients (mean forced expiratory volume one second 34% predicted, mean resting saturation 94%) attended a respiratory gymnasium undertook four 6‐min walk (6MW) tests at each two sessions, 1 week...
Short-burst oxygen therapy (SBOT) remains widely advocated for patients with chronic obstructive pulmonary disease (COPD), despite a lack of supporting evidence. The aim this randomised, double-blind, placebo-controlled, parallel group study was to determine whether SBOT improves health-related quality life (HRQL) or reduces acute healthcare utilisation in discharged following an exacerbation COPD. Consecutive were screened; 78 331 eligible randomisation cylinder oxygen, air usual care...
ABSTRACT Background and Aims This study evaluated whether there are ethnic factors which affect the severity progression of bronchiectasis in our adult multi‐ethnic population Auckland, New Zealand. Methods Clinical records were reviewed from patients attending outpatient facilities institution between 2007 2010. Data collected included demographics, clinical features, smoking status, self‐reported ethnicity, socioeconomic status (NZDep), pulmonary function sputum microbiology. Results A...
Guidelines for long term oxygen therapy (LTOT) recommend increasing flow by 1 l/min overnight. A study was undertaken in patients with COPD on LTOT to determine the prevalence of overnight desaturation if usual rate is not increased at night, whether resting saturation predicts desaturation, and correlates health related quality life (HRQL) sleep quality.A cross sectional prospective performed consecutive attending our regional outpatient service. All fulfilled standard criteria LTOT, had...
Electrocardiogram in Alcoholism-Priest et al.DBRITISH 1455were doing many of them, we used the Atlas Computer (Rees, 1964).Correlation electrocardiographic changes with other variables showed that abnormal E.C.G.s were significantly associated body-weights specific occurred seldom underweight patients (tau = 0.44; P 0.02) and never our obese -0.46;P 0.02), which
Recognition of pulmonary involvement in extra-pulmonary tuberculosis (TB) may be an important public health issue, as smear-negative TB is responsible for about 17% new infections. Pulmonary can present despite a normal chest x-ray (CXR), even human immunodeficiency virus (HIV)-negative patients. In this retrospective clinical audit, we reviewed case series HIV-negative patients with to identify the proportion concurrent unremarkable CXR.Clinical notes, microbiology results and CXR reports...
Following the observation that relatives of cystic fibrosis (CF) patients have an increased mortality due to leukaemia, a study was initiated determine whether leukaemia had prevalence ΔF508 CF mutation. No increase in carriers were found among leukaemias; however carrier frequency mutation appeared be reduced with malignant melanoma analysed as control group compared normal population. This paper extends our previous and investigates several other common human tumours, including those...
The incidence of sterilisation clip migration is reportedly 25%. However, less than 1% those who experience will present with pain, an abscess, or spontaneous extrusion. Here we a rare case through the entire pelvic floor.
To investigate the clinical validity and utility of tests for detecting Epidermal Growth Factor Receptor (EGFR) gene mutations in non-squamous non-small cell lung cancer patients, tumour DNA extracts from 532 patients previously tested by cobas EGFR Mutation Test (RT-PCR test) were retested Sequenom/Agena Biosciences MassArray OncoFocus mass spectrometry test (MS test). Valid results both available 470 (88%) agreement analysis. Survival data obtained 513 (96%) 77 (14%) treated with tyrosine...
Abstract Background Lung cancer is a major cause of death in New Zealand. In recent years, targeted therapies have improved outcomes. Aim To determine the uptake anaplastic lymphoma kinase (ALK) testing, and prevalence, demographic profile outcomes ALK‐positive non‐small‐cell lung (NSCLC), Zealand, where no national ALK‐testing guidelines or subsidised ALK tyrosine inhibitor (TKI) are available. Methods A population‐based observational study reviewed databases to identify patients presenting...
Diethyl and diphenyl disulfides, naphtha sweetening (Chemical Abstracts Service [CAS] # 68955-96-4), are primarily composed of low-molecular-weight dialkyl disulfides extracted from C 4 to 5 light hydrocarbon streams during the refining crude oil. The substance, commonly known as disulfide oil (DSO), can be up 17 different trisulfides with monoalkyl chain lengths no greater than . in DSO constitute a homologous series chemical constituents that perfectly suited for hazard evaluation using...
The measurement of total body water (TBW)) by bioelectrical impedance (BEI) in a group renal patients was evaluated against the tritium dilution method. effect haemodialysis and presence peritoneal dialysate on were also investigated. correlation between two methods r = 0.9, with standard deviation differences being 3.66 l (TBW typically 40 l). BEI method overestimated actual weight loss after haemodialysis, but underestimated volume situ. would not be appropriate for use assessing...
New Zealand has a low burden of tuberculosis; however, multidrug-resistant tuberculosis (MDR-TB) still represents challenge for clinicians. This is the first description clinical aspects MDR-TB in Zealand.To evaluate treatment and outcomes patients with disease Auckland. Secondary aims were to review incidence characteristics disease.Clinical data obtained treated at Auckland District Health Board (ADHB).There 60 nationally between 1989 2018; 41 (69%) received care ADHB. Pulmonary infection...