A5006711658- Liver Disease Diagnosis and Treatment
- Birth, Development, and Health
- Diet and metabolism studies
- Epigenetics and DNA Methylation
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Bariatric Surgery and Outcomes
- Pancreatic function and diabetes
- Health Systems, Economic Evaluations, Quality of Life
- Multiple Myeloma Research and Treatments
- Liver Disease and Transplantation
- Dietary Effects on Health
- Meta-analysis and systematic reviews
- Acute Myeloid Leukemia Research
- Alcohol Consumption and Health Effects
- Cancer-related gene regulation
- Endoplasmic Reticulum Stress and Disease
- Protein Degradation and Inhibitors
- Statistical Methods in Clinical Trials
- Selenium in Biological Systems
- Liver physiology and pathology
- Peptidase Inhibition and Analysis
- Head and Neck Cancer Studies
- Lipid metabolism and biosynthesis
- Botanical Research and Applications
Sanofi (France)
2024
Sanofi (United Kingdom)
2024
IQVIA (United Kingdom)
2021
University College London
1966-2019
The Royal Free Hospital
2015-2019
Roland Hill (United Kingdom)
2016-2019
Institute for Liver Health
2017-2018
Clinica Universidad de Navarra
2017
Universidad de Navarra
2008-2016
University of Puerto Rico System
2011
Epigenetics could help to explain individual differences in weight loss after an energy-restriction intervention. Here, we identify novel potential epigenetic biomarkers of loss, comparing DNA methylation patterns high and low responders a hypocaloric diet. Twenty-five overweight or obese men participated 8-wk caloric restriction was isolated from peripheral blood mononuclear cells treated with bisulfite. The basal endpoint between were analyzed by microarray, which also useful changes due...
The huge health burden accompanying obesity is not only attributable to inadequate dietary and sedentary lifestyle habits, since a predisposing genetic make-up other putative determinants concerning easier weight gain fat deposition have been reported. Thus, several investigations aiming understand energy metabolism body composition maintenance performed considering the participation of perinatal nutritional programming epigenetic processes as well inflammation phenomena. Developmental...
Objective Targeting bacterial translocation in cirrhosis is limited to antibiotics with risk of antimicrobial resistance. This study explored the therapeutic potential a non-absorbable, gut-restricted, engineered carbon bead adsorbent, Yaq-001 models and acute-on-chronic liver failure (ACLF) and, its safety tolerability clinical trial cirrhosis. Design Performance was evaluated vitro . Two-rat ACLF, (4 weeks, bile duct ligation or without lipopolysaccharide), receiving for 2 weeks; two-mouse...
Obesity and stroke are multifactorial diseases in which genetic, epigenetic lifestyle factors involved. The research aims were, first, the description of genes with differential regulation obtained by an 'omics' approach patients ischemic and, second, to determine importance some regions these selected biological processes depending on body mass index. A case-control study using two populations was designed. first population consisted 24 volunteers according stroke/non-stroke normal...
Methyl donor supplementation has been reported to prevent obesity-induced liver fat accumulation in adult rats. We hypothesized that this protection could be mediated by perinatal nutrition. For purpose, we assessed the response an obesogenic diet (high-fat-sucrose, HFS) during adulthood depending on maternal lactation. Female Wistar rats fed control pregnancy were assigned four postpartum dietary groups: control, supplemented with methyl donors (choline, betaine, folic acid, vitamin B 12 ),...
Maternal perinatal nutrition may program offspring metabolic features. Epigenetic regulation is one of the candidate mechanisms that be affected by maternal dietary methyl donors intake as potential controllers plasma homocysteine levels. Thirty-two Wistar pregnant rats were randomly assigned into four groups during lactation: control, control supplemented with donors, high-fat-sucrose and donors. Physiological outcomes in measured, including hepatic mRNA expression global DNA methylation...
The prevalence of non-alcoholic fatty pancreas disease (NAFPD) is increasing in parallel with obesity rates. Stress-related alterations endoplasmic reticulum (ER), such as the unfolded protein response (UPR), are associated obesity. aim this study was to investigate ER imbalance a mice model adult and perinatal diet-induced Twenty female C57BL/6J were assigned control (Con) or obesogenic (Ob) diets prior during pregnancy lactation. Their offspring weaned onto Con Ob up 6 months post-partum....
We investigated the regulation of hepatic ER stress in healthy liver and adult or perinatally programmed diet-induced non-alcoholic fatty disease (NAFLD). Female mice were fed either obesogenic control diet before mating, during pregnancy lactation. Post-weaning, offspring from each maternal group divided into diet. At six months, sacrificed at 4-h intervals over 24 h. Offspring diets developed NAFLD phenotype, combination exacerbated this phenotype. UPR signalling pathways (IREα, PERK,...
The incidence of nonalcoholic fatty liver disease (NAFLD) continues to parallel the rise in obesity rates. Endobariatric devices such as intragastric balloon (IGB) may provide an alternative treatment option.Outcomes following IGB 135 patients with and NAFLD (mean baseline weight 117.9 kg; BMI 41.7 kg/m2; HOMA-IR 3.6) were retrospectively examined. Clinical, anthropometric, biochemical changes analysed at six months after consecutive two three serial IGBs.After months, significant seen...
Interpretation of renin-angiotensin blockade with angiotensin converting enzyme inhibitors is potentially confounded by their multiple effects. We used a selective renin inhibitor (enalkiren, A-64662) to explore the renal and endocrine effects II in healthy men. Each received 90-minute enalkiren infusions at 2-day intervals, on low (10 mmol, 16 subjects) high (200 12 salt diet. Plasma activity, immunoreactive plasma aldosterone concentrations, inulin, p-aminohippurate clearance were measured...
The parasympathetic nervous system (PNS), via neurotransmitter acetylcholine (ACh), modulates fibrogenesis in animal models. However, the role of ACh human hepatic is unclear.We aimed to determine fibrogenic responses stellate cells (hHSC) and relevance PNS fibrosis patients with non-alcoholic steatohepatitis (NASH).Primary hHSC were analyzed for synthesis endogenous acetylcholinesterase gene expression choline acetyltransferase muscarinic receptors (mAChR). Cell proliferation markers...
Summary Maternal nutrition during pregnancy and lactation influences offspring development health. Novel studies have described the effects on next generation obesity‐related features depending maternal macro‐ micro‐nutrient perinatal feeding. We hypothesized that obesogenic diet programs an obese phenotype, while micronutrient supplementation at these stages could partially prevent features. Thus, aim was to assess influence of a feeding with enriched in fat sucrose growth phenotypical life...
Maternal obesity predisposes offspring to metabolic dysfunction and Non-Alcoholic Fatty Liver Disease (NAFLD). Melanocortin-4 receptor (Mc4r)-deficient mouse models exhibit during adulthood. Here, we aim determine the influence of Mc4r gene on liver mice subjected perinatal diet-induced obesity. Female heterozygous for fed an obesogenic or a control diet 5 weeks were mated with males, same continued throughout pregnancy lactation, generating four groups: wild type (C_wt), knockout (C_KO),...