A5100691260- Antifungal resistance and susceptibility
- Nanoplatforms for cancer theranostics
- Antimicrobial agents and applications
- Orthopedic Infections and Treatments
- Nanoparticle-Based Drug Delivery
- Bacterial biofilms and quorum sensing
- Cancer, Hypoxia, and Metabolism
- Iron oxide chemistry and applications
- Histone Deacetylase Inhibitors Research
- Crystallization and Solubility Studies
- Antioxidant Activity and Oxidative Stress
- Chromatography in Natural Products
- Antimicrobial Resistance in Staphylococcus
- Lung Cancer Diagnosis and Treatment
- Sulfur Compounds in Biology
- Oral health in cancer treatment
- Pharmacological Effects of Natural Compounds
- Selenium in Biological Systems
- Nail Diseases and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Nanoparticles: synthesis and applications
- Reproductive tract infections research
- Advanced Drug Delivery Systems
- Phytochemical compounds biological activities
- Immune cells in cancer
Xi'an Jiaotong University
2019-2023
Shanghai Jiao Tong University
2017-2023
State Key Laboratory of Oncogene and Related Genes
2021-2023
Huazhong University of Science and Technology
2014
Abstract The induced expansion of tumor‐initiating cells (T‐ICs) upon repeated exposure tumors to chemotherapeutic drugs forms a major cause for chemoresistance and cancer metastasis. Here, tumor‐microenvironment‐responsive hydrogel patch is designed modulate the plasticity T‐ICs in triple‐negative breast (TNBC), which insensitive hormone‐ HER2‐targeting. on‐site formation network patches chemoresistant TNBC murine model senses intratumoral reactive oxygen species linker cleavage payload...
Induction of immunogenic cell death (ICD) plays crucial roles in cancer immunotherapy, whereas its efficacy is severely compromised by redundant antioxidant defenses cells and aberrant lipid metabolism immunosuppressive populations. In this work, it found that hollow mesoporous CuS nanoparticles (NPs) possess an intrinsic capacity inhibiting glutathione peroxidase 4 (GPX4). When loaded with inhibitor the ferroptosis suppressor protein 1 (FSP1), these NPs block two parallel redox systems...
Naringin (NG) has been proved to have numerous notable biological effects, including anti-inflammatory effect, anti-cancer and anti-ulcer yet there are no clinical preparations of naringin due its poor solubility low dissolution rate after oral administration. In this study, in order overcome these problems, NG was encapsulated into MPEG-PCL micelles (NGMs) by using a thin-film hydration method. NMGs were typical core-shell structure, with mall particle size (23.95 ± 0.51 nm), high drug...
Abstract Objectives Organic Selenium (Se) compounds such as L‐Se‐methylselenocysteine (L‐SeMC/SeMC) have been employed a class of anti‐oxidant to protect normal tissues and organs from chemotherapy‐induced systemic toxicity. However, their comprehensive effects on cancer cell proliferation tumour progression remain elusive. Materials Methods CCK‐8 assays were conducted determine the viabilities cells after exposure SeMC, chemotherapeutics or combined treatment. Intracellular reactive oxygen...
Baicalein is a traditional Chinese medicine with multiple pharmacological effects, including anti-inflammatory activity, anti-pathogen antitumor activity and neuroprotective activity. However, due to the limited solubility poor stability in aqueous solution, its clinical application greatly compromised. Here, we investigated thermodynamic properties of baicalein binary system water ethanol from 283.15 K 328.15 (common temperature labs pharmaceutical industry), order optimize extraction...
Background:Candida albicans catheter-related infection (CRI) is a great challenge in clinic now, mainly due to the difficulty eradicating biofilms. Purpose: In this study, mechanism of antibiofilm effect myricetin (MY) on C. was illustrated. A film forming system (FFS) containing MY and miconazole nitrate (MN) developed, optimized, evaluated. The anti-infection MY+MN@FFS against CRI investigated vivo. Study Design Methods: To clarify action MY, influence each key process formation biofilms...
External beam radiotherapy increases the risk of Candida vaginitis in cervical cancer patients, which brings a lot insufferable influence to their life. Here, we explored efficacy alkannin treatment after external radiotherapy. We exploit thermosensitive hydrogel-mediated as topical formulation rat model established our work. Periodic acid-Schiff vaginas indicated little albicans adhered vaginal tissue group. Additionally, hematoxylin and eosin stain revealed that inflammatory response high...