A5007965226- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- interferon and immune responses
- Virus-based gene therapy research
- Head and Neck Cancer Studies
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
Michigan State University
2020-2024
Michigan United
2020-2023
ABSTRACT The human papillomavirus (HPV) oncoprotein E7 is a relatively short-lived protein required for HPV-driven cancer development and maintenance. degraded through ubiquitination mediated by cullin 1 (CUL1) the ubiquitin-conjugating enzyme E2 L3 (UBE2L3). However, proteins are maintained at high levels in most HPV-positive cells. A previous proteomics study has shown that UBE2L3 CUL1 increased knockdown of E3 ubiquitin ligase membrane-associated ring-CH-type finger 8 (MARCHF8). We have...
The membrane-associated RING-CH-type finger ubiquitin ligase MARCHF8 is a human homolog of the viral ligases Kaposi’s sarcoma herpesvirus K3 and K5 that promote host immune evasion. Previous studies have shown ubiquitinates several receptors, such as major histocompatibility complex II CD86. While papillomavirus (HPV) does not encode any ligase, oncoproteins E6 E7 are known to regulate ligases. Here, we report expression upregulated in HPV-positive head neck cancer (HNC) patients but...
The loss of major histocompatibility complex class I (MHC-I) molecules has been proposed as a mechanism by which cancer cells evade tumor-specific T in immune checkpoint inhibitor (ICI)-refractory patients. Nevertheless, the downregulate MHC-I is poorly understood. We report here that membrane-associated RING-CH-type finger 8 (MARCHF8), upregulated human papillomavirus (HPV), ubiquitinates and degrades proteins HPV-positive head neck (HPV+ HNC). MARCHF8 knockdown restores levels on HPV+ HNC...
By Nicholas Giacobbi. Human papillomavirus-positive head and neck squamous cell carcinoma has limited expression of MHC-I molecules for antigen presentation, resulting in immune evasion efficacy checkpoint inhibitor therapy.
The human papillomavirus (HPV) oncoprotein E7 is a relatively short-lived protein required for HPV-driven cancer development and maintenance. degraded through ubiquitination mediated by cullin 1 (CUL1) the ubiquitin-conjugating enzyme E2 L3 (UBE2L3). However, proteins are maintained at high levels in most HPV-positive cells. A previous proteomics study has shown that UBE2L3 CUL1 increased knockdown of E3 ubiquitin ligase membrane-associated ring-CH-type finger 8 (MARCHF8). We have recently...
ABSTRACT The membrane-associated RING-CH-type finger ubiquitin ligase MARCHF8 is a human homolog of the viral ligases Kaposi’s sarcoma herpesvirus K3 and K5 that promote host immune evasion. Previous studies have shown ubiquitinates several receptors, such as major histocompatibility complex II CD86. While papillomavirus (HPV) does not encode any ligase, oncoproteins E6 E7 are known to regulate ligases. Here, we report expression upregulated in HPV-positive head neck cancer patients but...