A5039601931- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- 3D Printing in Biomedical Research
- Cancer Genomics and Diagnostics
- Nanoparticle-Based Drug Delivery
- Cellular Mechanics and Interactions
- Ferroptosis and cancer prognosis
- Advanced Polymer Synthesis and Characterization
- Pickering emulsions and particle stabilization
- Surfactants and Colloidal Systems
- Hydrogels: synthesis, properties, applications
- Gastric Cancer Management and Outcomes
- Drug Solubulity and Delivery Systems
Korea Advanced Institute of Science and Technology
2007-2025
Korea Institute of Brain Science
2021
Abstract Conventional tumor models have critical shortcomings in that they lack the complexity of human stroma. The heterogeneous stroma is a central compartment microenvironment (TME) must be addressed cancer research and precision medicine. To fully model stroma, deconstruction reconstruction tissues been suggested as new approaches for vitro modeling. In this review, we summarize heterogeneity tumor-associated stromal cells general used to isolate patient-specific from tissue; also...
When embedded into a three-dimensional (3D) matrix, cancer stem cells (or cancer-initiating cells) can grow self-organizing organotypic structures called tumor organoids. During organoid formation, the matrix not only provides structural support but also delivers biochemical signals. Although increasing evidence indicates that extracellular (ECM) is an essential component of microenvironment during development and progression, influence ECM on formation has been largely ignored; recently...
Abstract Background Understanding the proteomic-level heterogeneity of tumor microenvironment (TME) in colorectal cancer (CRC) is crucial due to its well-known heterogeneity. While heterogenous CRC has been extensively characterized at molecular subtype level, research into functional fibroblasts, particularly their relationship with extracellular matrix (ECM) alterations, remains limited. Addressing this gap essential for a comprehensive understanding progression and development targeted...
A new synthesis approach for the preparation of pH-responsive nanogels via core hydrolysis cross-linked polymer micelles is proposed. The core–shell poly(ethylene glycol)–poly(aspartic acid) exhibited a swelling behavior attributed to ionization aspartic acids, and depended on cross-linking density. Small-angle neutron scattering (SANS) data were used investigate structure fitting analysis based model equation that describes two distinguishable intensities arise from particle fluctuation...
The self-assembly of nanocrystals using a bottom-up approach is advantageous because it possible to control their direct structure at nanometre length scale and collective optical electronic properties. Here, we present the novel fabrication aqueous amphiphilic nanocrystallo-polymers. Hydrophobic are used as hydrophobic component amphiphiles, they can drive interaction-mediated create various nanostructures, such spherical aggregates, core-shell unimolecular micelles, cylinders. be uniformly...