A5023759483- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Immune cells in cancer
- Cancer Mechanisms and Therapy
- Proteoglycans and glycosaminoglycans research
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- TGF-β signaling in diseases
- Immune Cell Function and Interaction
Mahidol University
2017-2024
New York University
2019
Abstract A poor outcome for cholangiocarcinoma (CCA) patients is still a clinical challenge. CCA typically recognized by the desmoplastic nature, which accounts its malignancy. Among various extracellular matrix proteins, laminin most potent inducer migration. Herein, we accessed expression profiles of gene family and explored significance key subunit on aggressiveness. Of all 11 genes, LAMA3, LAMA5, LAMB3 LAMC2 were concordantly upregulated based analysis multiple public transcriptomic...
Abstract Unconventional T-lymphocyte populations are emerging as important regulators of tumor immunity. Despite this, the role TCRαβ+CD4−CD8−NK1.1− innate αβ T cells (iαβT) in pancreatic ductal adenocarcinoma (PDA) has not been explored. We found that iαβTs represent ∼10% lymphocytes infiltrating PDA mice and humans. Intratumoral express a distinct T-cell receptor repertoire profoundly immunogenic phenotype compared with their peripheral counterparts conventional lymphocytes. comprised ∼75%...
Transforming growth factor-β (TGF-β) plays a paradoxical role in cancer: it suppresses proliferation at early stages but promotes metastasis late stages. This cytokine is upregulated cholangiocarcinoma and implicated invasion metastasis. Here we investigated the roles of non-Smad pathway (ERK1/2) Smad TGF-β tumor promoting suppressing activities intrahepatic (ICC) cells. TGF-β1 effects on proliferation, migration ICC cells, KKU-M213 and/or HuCCA-1, were using MTT, colony formation, vitro...
Extensive desmoplasia in cholangiocarcinoma (CCA) is associated with tumor aggressiveness, indicating a need for further understanding of CCA cell–matrix interaction. This study demonstrated laminin as the most potent attractant cell migration and vast elevation its receptor integrin β4 (ITGB4) lines. Besides, their high expressions tissues were correlated lymphatic invasion presence ITGB4 was also short survival time. silencing revealed it laminin-induced HuCCA-1 migration, but KKU-213...
Cholangiocarcinoma (CCA), a devastating epithelial tumor arising in bile ducts with dismal prognosis and high mortality rate, has the highest worldwide incidence Northeastern Thailand, raising serious health public concern to country.Due desmoplastic nature of CCA, understanding CCA cell-matrix interaction is necessitated.Here, an silico analysis using two RNA-sequencing (Pan-Cancer Analysis Whole Genomes The Cancer Genome Atlas) databases ten microarray datasets from Gene Expression Omnibus...