A5053156005- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Toxoplasma gondii Research Studies
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Parasites and Host Interactions
- Bacterial biofilms and quorum sensing
- Single-cell and spatial transcriptomics
- Phagocytosis and Immune Regulation
- Ferroptosis and cancer prognosis
- interferon and immune responses
- HIV Research and Treatment
- Antimicrobial agents and applications
- Bacterial Infections and Vaccines
- Antimicrobial Peptides and Activities
- Parasitic Infections and Diagnostics
- Autophagy in Disease and Therapy
- Cytomegalovirus and herpesvirus research
- Cancer Diagnosis and Treatment
- Inhalation and Respiratory Drug Delivery
NYU Langone Health
2019-2020
New York University
2019
Rutgers, The State University of New Jersey
2008-2016
Rutgers New Jersey Medical School
2013
Beta-catenin signaling has recently been tied to the emergence of tolerogenic dendritic cells (DCs). In this article, we demonstrate a novel role for beta-catenin in directing DC subset development through IFN regulatory factor 8 (IRF8) activation. We found that splenic precursors express beta-catenin, and DCs from mice with CD11c-specific constitutive activation upregulated IRF8 targeting Irf8 promoter, leading vivo expansion IRF8-dependent CD8a+, plasmacytoid, CD103+ CD11b2 DCs....
ABSTRACT Biofilms are composed of bacterial cells encased in a self-synthesized, extracellular polymeric matrix. Poly-β(1,6)- N -acetyl- d -glucosamine (PNAG) is major biofilm matrix component phylogenetically diverse bacteria. In this study we investigated the physical and chemical properties PNAG biofilms produced vitro by gram-negative porcine respiratory pathogen Actinobacillus pleuropneumoniae gram-positive device-associated Staphylococcus epidermidis . The effect on bulk fluid flow was...
Abstract Concurrent helminth infection potently inhibits T cell immunity; however, whether helminthes prevent priming or skew clonal recruitment and effector differentiation is not known. Using coinfection with two natural mouse pathogens, Heligmosomoides polygyrus Toxoplasma gondii, to investigate the negative impact of on CD8 response, we demonstrate helminth-induced suppression IL-12–dependent killer-like receptor G1+ cells IFN-γ production. Nevertheless, reversal innate IL-12 response...
The proinflammatory cytokine IL-12 drives the generation of terminally differentiated KLRG1(+) effector CD8(+) T cells. Using a Toxoplasma vaccination model, we delineate sequence events that naïve cells undergo to become terminal effectors and differentiation steps controlled by IL-12. We demonstrate direct signaling on is essential for induction KLRG1 IFN-γ, but subsequent downregulation CXCR3 indirectly through actions IFN-γ IFN-γ-inducible chemokines. Differentiation nascent occurs in an...
Abstract Unconventional T-lymphocyte populations are emerging as important regulators of tumor immunity. Despite this, the role TCRαβ+CD4−CD8−NK1.1− innate αβ T cells (iαβT) in pancreatic ductal adenocarcinoma (PDA) has not been explored. We found that iαβTs represent ∼10% lymphocytes infiltrating PDA mice and humans. Intratumoral express a distinct T-cell receptor repertoire profoundly immunogenic phenotype compared with their peripheral counterparts conventional lymphocytes. comprised ∼75%...
Abstract We have previously shown that IL-12 is necessary for the differentiation of KLRG1+ IFN-γ producing CD8+ T effector cells during immune response to Toxoplasma gondii. However, which key events activation, and mobilization are critically regulated by not been identified. By tracking dynamics endogenous adoptively transferred T. gondii-reactive cells, we were able identify two dependent checkpoints. critical early diversification into IFN-γ-producing occurs even prior their initial...
<div>Abstract<p>Unconventional T-lymphocyte populations are emerging as important regulators of tumor immunity. Despite this, the role TCRαβ<sup>+</sup>CD4<sup>−</sup>CD8<sup>−</sup>NK1.1<sup>−</sup> innate αβ T cells (iαβT) in pancreatic ductal adenocarcinoma (PDA) has not been explored. We found that iαβTs represent ∼10% lymphocytes infiltrating PDA mice and humans. Intratumoral express a distinct T-cell receptor repertoire...
<p>Supp Figures 1-7 and Legends</p>
<p>Supp Table 1</p>
<p>Supp Figures 1-7 and Legends</p>
<p>Supp Table 1</p>
<div>Abstract<p>Unconventional T-lymphocyte populations are emerging as important regulators of tumor immunity. Despite this, the role TCRαβ<sup>+</sup>CD4<sup>−</sup>CD8<sup>−</sup>NK1.1<sup>−</sup> innate αβ T cells (iαβT) in pancreatic ductal adenocarcinoma (PDA) has not been explored. We found that iαβTs represent ∼10% lymphocytes infiltrating PDA mice and humans. Intratumoral express a distinct T-cell receptor repertoire...
Abstract The obligate intracellular parasite Toxoplasma gondii elicits a robust and uniquely IL-12 dependent CD8+ T cell immune response. We have previously shown that is required for the differentiation of KLRG1+ effector cells following T. infection. also in absence IL-12, frequency KLRG1- memory precursor (MPECs) increased at expense short-lived (SLECs). Therefore, may be critical signal early phase bifurcation naïve into SLEC MPEC-fated lymphocytes. To determine if SLECs MPECs are...
Abstract Triple negative breast cancer (TNBC) is an aggressive subtype of with poor prognosis when metastatic. Immunotherapy, especially in combination taxane chemotherapy has recently been shown to improve outcomes PD-L1 as predictive biomarker for survival. To understand the mechanisms response/resistance chemo-immunotherapy TNBC, we obtained serial core biopsies TNBC patients (n=30) undergoing nab-paclitaxel and pembrolizumab treatment a prospective trial at three time points, including...
Abstract The emergence of immune checkpoint inhibitors has changed the treatment paradigm for NSCLC. Recently, immunotherapy in combination with chemotherapy was shown to be a promising first-line strategy patients squamous cell lung cancer, where targeted therapy had little efficacy due pathological driver mutations this disease being poorly understood. However, both adenocarcinoma and NSCLC, use such improve outcome only subset advanced or metastatic disease. Understanding diversity tumor...
Triple negative breast cancer (TNBC) is an aggressive subtype of with poor prognosis when metastatic. Immunotherapy, especially in combination taxane chemotherapy has recently been shown to improve outcomes PD-L1 as predictive biomarker for survival. To understand the mechanisms response/resistance chemo-immunotherapy TNBC, we obtained serial core biopsies TNBC patients (n=30) undergoing nab-paclitaxel and pembrolizumab treatment a prospective trial at three time points, including baseline...
The emergence of immune checkpoint inhibitors has changed the treatment paradigm for NSCLC. Recently, immunotherapy in combination with chemotherapy was shown to be a promising first-line strategy patients squamous cell lung cancer, where targeted therapy had little efficacy due pathological driver mutations this disease being poorly understood. However, both adenocarcinoma and NSCLC, use such improve outcome only subset advanced or metastatic disease. Understanding diversity tumor...