A5048397252- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- Chemotherapy-induced organ toxicity mitigation
- Advanced biosensing and bioanalysis techniques
- Turkey's Politics and Society
- Antimicrobial Peptides and Activities
- Antimicrobial agents and applications
- Urinary Bladder and Prostate Research
- Healthcare and Venom Research
- Electrolyte and hormonal disorders
- Bacteriophages and microbial interactions
- Educational Methods and Analysis
- Polymer Surface Interaction Studies
- Cancer Diagnosis and Treatment
- Islamic Thought and Society Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer therapeutics and mechanisms
- Legal Issues in Turkey
- Educational Assessment and Pedagogy
- Lipid Membrane Structure and Behavior
- Corneal Surgery and Treatments
- Mathematics Education and Teaching Techniques
- Advanced Polymer Synthesis and Characterization
- Cancer-related cognitive impairment studies
- Radiomics and Machine Learning in Medical Imaging
Helmholtz Institute for Pharmaceutical Research Saarland
2019-2022
Helmholtz Centre for Infection Research
2019-2022
Saarland University
2021-2022
Karadeniz Technical University
2018-2019
L-theanine is the unique amino acid found in tea plants, has antioxidant and antiinflammatory activities, functions mental concentration sleep quality. In this study, it aimed to investigate effects of on doxorubicin (DOX, a chemotherapeutic agent) induced nephrotoxicity rats, especially via GSH related enzymes.32 male Sprague Dawley rats weighing 300-400 g were randomly assigned into 4 groups (n = 8) substances given intraperitoneally them: Control group (saline for 5 days); Theanine (200...
Antivirulence therapy has become a widely applicable method for fighting infections caused by multidrug-resistant bacteria. Among the many virulence factors produced Gram-negative bacterium Pseudomonas aeruginosa, elastase (LasB) stands out as an important target it plays pivotal role in invasion of host tissue and evasion immune response. In this work, we explored recently reported LasB inhibitor class α-benzyl-N-aryl mercaptoacetamides exploiting crystal structure one compounds. Our...
Extracellular virulence factors have emerged as attractive targets in the current antimicrobial resistance crisis. The Gram-negative pathogen Pseudomonas aeruginosa secretes factor elastase B (LasB), which plays an important role infection process. Here, we report a sub-micromolar, non-peptidic, fragment-like inhibitor of LasB discovered by careful visual inspection structural data. Inspired natural substrate, original fragment was successfully merged and grown. optimized is accessible via...
Drug-resistant pathogens pose a global challenge to public health as they cause diseases that are extremely difficult cure. Metallo-β-lactamases (MBLs) diverse set of zinc-containing enzymes catalyze the hydrolysis β-lactam drugs, including carbapenems, which considered last resort fight severe infections. To restore activity current antibiotics and offer an orthogonal strategy discovery new antibiotics, we have identified series polar N-aryl mercaptopropionamide derivatives potent...
RAD51 is an ATP-dependent recombinase, recruited by BRCA2 to mediate DNA double-strand breaks repair through homologous recombination and represents attractive cancer drug target. Herein, we applied for the first-time protein-templated dynamic combinatorial chemistry on as a hit identification strategy. Upon design of N-acylhydrazone-based libraries, showed clear templating effect, amplifying 19 N-acylhydrazones. Screening against RAD51-BRCA2 protein-protein interaction via ELISA assay...
The spherical micelles of the carbazole monomer transformed into nanorods in course polymerization. polymeric show pH-dependent changes fluorescence emission and size.
As resistance to clinically available antibiotics persistently increases, applying new strategies target pathogenic bacteria are paramount design effective drugs. Bacterial proteases play vital roles in cell viability and stress response, contributing the pathogenicity of resistant bacteria. Targeting these extracellular enzymes by antivirulence therapy is a prominent strategy combating multi-drug By preventing colonization infiltration host, this method can lower selection pressure reduce...
Abstract Extrazelluläre Virulenzfaktoren haben sich als attraktive Ziele in der aktuellen Antibiotikaresistenzkrise erwiesen. Der Gram‐negative Erreger Pseudomonas aeruginosa sezerniert den Virulenzfaktor Elastase B (LasB), eine wichtige Rolle im Infektionsprozess spielt. Hier berichten wir über einen submikromolaren, nicht‐peptidischen, fragmentartigen Inhibitor von LasB, durch sorgfältige visuelle Analyse Strukturdaten entdeckt wurde. In Anlehnung an das natürliche LasB‐Substrat wurde...