A5011153971- Epigenetics and DNA Methylation
- ECG Monitoring and Analysis
- Birth, Development, and Health
- Photoreceptor and optogenetics research
- Mitochondrial Function and Pathology
- Identity, Memory, and Therapy
- Health, Environment, Cognitive Aging
- Metabolomics and Mass Spectrometry Studies
- High Altitude and Hypoxia
- EEG and Brain-Computer Interfaces
- Ferroptosis and cancer prognosis
- Neuroscience and Neuropharmacology Research
- Blind Source Separation Techniques
- Intergenerational Family Dynamics and Caregiving
- Cardiac electrophysiology and arrhythmias
- Genetic Syndromes and Imprinting
- Neural dynamics and brain function
- Dietary Effects on Health
- Machine Learning in Healthcare
- Dialysis and Renal Disease Management
- Single-cell and spatial transcriptomics
- stochastic dynamics and bifurcation
- Neuroscience and Neural Engineering
- RNA modifications and cancer
- Family Support in Illness
N. I. Lobachevsky State University of Nizhny Novgorod
2016-2024
Institute for System Programming
2022-2023
Institute of Information Technologies
2020
We report Lobachevsky University Database (LUDB) of ECG signals, an open tool for validating delineation algorithms, that is superior to the existing publicly available data bases in several aspects. LUDB contains 200 recordings 10-second 12-lead electrocardiograms (ECG) from different subjects, representative a variety signal morfologies. The boundaries and peaks QRS complexes P T waves are manually annotated by cardiologists all independently each lead, records received expert...
Background: We present EpImAge, an explainable deep learning tool that integrates epigenetic and immunological markers to create a highly accurate, disease-sensitive biological age predictor. This novel approach bridges two key hallmarks of aging - alterations immunosenescence. Methods: First, immunologic data from the same participants was used for AI models predicting levels 24 cytokines blood DNA methylation. Second, open-source (25 thousand samples) generating synthetic biomarkers...
Abstract This study is the first systematic meta-analysis of epigenetic age acceleration largest publicly available DNA methylation data for healthy samples (93 datasets, 23K samples), focusing on geographic and ethnic aspects different countries (25 countries) populations (31 ethnicities) around world. The most popular tools assessing were examined in detail, their quality metrics analyzed, ability to extrapolate from tissue types ranges training these models was explored. In cases, are not...
The aging process affects all systems of the human body, and observed increase in inflammatory components affecting immune system old age can lead to development age-associated diseases systemic inflammation.We propose a small clock model SImAge based on limited number immunological biomarkers. To regress chronological from cytokine data, we first use baseline Elastic Net model, gradient-boosted decision trees models, several deep neural network architectures. For full dataset 46 parameters,...
Networks have been established as an extremely powerful framework to understand and predict the behavior of many large-scale complex systems. We studied network motifs, basic structural elements networks, describe possible role co-occurrence genomic variations behind high altitude adaptation in Asian human population. Mitochondrial DNA (mtDNA) acclaimed one key players understanding biological mechanisms extreme conditions. To explore cumulative effects mitochondrial genome with variation...
Abstract Background Yakuts are one of the indigenous populations subarctic and arctic territories Siberia characterized by a continental climate with severe winters, regular January average temperature in regional capital city Yakutsk dipping below − 40 °C. The epigenetic mechanisms adaptation to such ecologies environments and, particular, age acceleration local population have not been studied before. Results This work reports first study Yakutian using whole-blood DNA methylation data,...
Bacterial chemotaxis is one of the most extensively studied adaptive responses in cells. Many bacteria are able to bias their apparently random motion produce a drift direction increasing chemoattractant concentration. It has been recognized that particular motility pattern employed by moving direct impact on efficiency chemotaxis. The linear theory pioneered de Gennes allows for calculation velocity small gradients with basic patterns. However, recent experimental data several bacterial...
Physiological and haplogroup studies performed to understand high-altitude adaptation in humans are limited individual genes polymorphic sites. Due stochastic evolutionary forces, the frequency of a polymorphism is affected by changes near-by on same DNA sample making them connected terms evolution. Here, first, we provide method model these mitochondrial polymorphisms as "co-mutation networks" for three populations, Tibetan, Ethiopian Andean. Then, transforming co-mutation networks into...
Abstract In humans, females live longer than males but experience a worse longevity, as genome-wide autosomal DNA methylation differences between and have been reported. So far, few studies investigated if is differently affected by aging in females. We performed meta-analysis of 4 large whole blood datasets, comparing aspects epigenetic age-dependent remodeling the two sexes: differential methylation, variability, epimutations entropy. reported that fraction (43%) sex-associated probes...
The aim of the study was to develop Cyberheart-Diagnostics software module, an automated electrocardiogram analysis system being part Cyberheart and hardware complex, select machine learning techniques for testing based on comparative their capabilities.Materials Methods.The package developed using various working a large sample labeled data, i.e.ECG database with known diagnostic conclusions: support-vector machines, decision tree, artificial neural networks, linear quadratic discriminant...
Optogenetics is a combination of optical and genetic technologies used to activate or, conversely, inhibit specific cells in living tissues. The possibilities using optogenetics approaches for the treatment epilepsy, Parkinson’s Alzheimer’s disease (AD) are being actively researched. In recent years, it has become clear that one most important players development AD astrocytes. Astrocytes affect amyloid clearance, participate neuroinflammation, regulate functioning neural networks. We an...
Yakutia is one of the coldest permanently inhabited regions in world, characterized by a subarctic climate with average January temperatures near −40 °C and minimum below −60 °C. Recently, we demonstrated accelerated epigenetic aging Yakutian population comparison to their Central Russian counterparts, residing considerably milder climate. In this paper, analyzed these cohorts from inflammaging perspective addressed two hypotheses: mismatch immunological profiles inflammatory Yakuts. We...