Sophie Léobon

ORCID: 0000-0001-9283-4763
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About
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Research Areas
  • Cancer survivorship and care
  • Nutrition and Health in Aging
  • Breast Cancer Treatment Studies
  • Colorectal Cancer Treatments and Studies
  • Childhood Cancer Survivors' Quality of Life
  • Cancer Treatment and Pharmacology
  • Cancer Risks and Factors
  • Patient-Provider Communication in Healthcare
  • Pharmaceutical Practices and Patient Outcomes
  • Nonmelanoma Skin Cancer Studies
  • Polyomavirus and related diseases
  • Radiomics and Machine Learning in Medical Imaging
  • Head and Neck Surgical Oncology
  • Multiple and Secondary Primary Cancers
  • Thyroid Cancer Diagnosis and Treatment
  • Clinical Reasoning and Diagnostic Skills
  • Oral health in cancer treatment
  • Chemotherapy-related skin toxicity
  • Transplantation: Methods and Outcomes
  • Prostate Cancer Treatment and Research
  • Advanced Radiotherapy Techniques
  • Esophageal Cancer Research and Treatment
  • Lymphatic System and Diseases
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Colorectal Cancer Surgical Treatments

Université de Limoges
2013-2024

Centre Hospitalier Universitaire de Limoges
2013-2024

Hôpital Universitaire Dupuytren
2015-2020

Hôpital Dupuytren
2013-2016

We investigated the impact of body composition on outcomes patients with early breast cancer. Skeletal muscle mass, visceral adipose tissue (VAT), subcutaneous (SAT), and fat infiltration or inter-muscular areas (IMAT), obtained by computed tomography (CT), were assessed.A total 119 female who had cancer included in this retrospective study. The skeletal evaluated two adjacent axial slices at third lumbar vertebra CT used for disease staging. women assigned to either a sarcopenia...

10.1007/s00520-017-3902-6 article EN cc-by-nc Supportive Care in Cancer 2017-09-25

Background: The COVID-19 pandemic has changed the organisation of medical care. Patients and Methods: This is first prospective observational study on patient-reported outcomes, quality life (HRQOL) satisfaction in patients with cancer their care management a day hospital during period May-June 2020. Generalised Anxiety Disorder Screener 12-Item Short-Form Health Survey were used. Results: survey was completed by 189 267 patients. They generally aged 61 to 70 years women presented lung,...

10.21873/invivo.12306 article EN In Vivo 2021-01-01

Objectives: Physical activity (PA) programs are recommended for breast cancer care. However, their modalities remain to be discussed. This study determined the best time begin a personalized or adapted program based on cardiopulmonary exercise test function. randomized controlled trial evaluated effect of home-based PA (APA) performed during after treatment cardiorespiratory fitness (CRF) at 12 months. Method: The primary endpoint was peak oxygen consumption (VO 2peak ) months (group A vs C...

10.1177/1534735420969818 article EN cc-by-nc Integrative Cancer Therapies 2020-01-01

Sinonasal intestinal-type adenocarcinomas (ITACs) have a poor prognosis, and are defined on the basis of their morphological similarities to colorectal adenocarcinomas. MET signaling pathway is involved in oncogenesis various cancers. Nothing currently known about role ITACs.In series 72 ITACs, we investigated protein levels by immunohistochemistry (IHC) gene copy number situ hybridization. These findings were analyzed as function clinical data, histological typing, patient outcome.MET was...

10.1002/hed.23795 article EN Head & Neck 2014-06-10

Management of glioblastoma, with a very poor prognosis, remains challenge in older patients because coexisting comorbidities and the increased risk toxic treatment effects. The use screening tools to identify vulnerable is essential. This study was performed establish whether G8 scale can be used for glioblastoma.We retrospectively reviewed files assessed by diagnosed glioblastoma at single center from January 2010 July 2017. Patients aged 65 years or were classified into three groups (more...

10.1016/j.jgo.2018.07.002 article EN cc-by-nc-nd Journal of Geriatric Oncology 2018-07-21

Background/Aim: To investigate the impact of body composition on morbidity and mortality at initial diagnosis localised renal cell carcinoma (RCC) in patients with overweight or obesity. Patients Methods: Sarcopenia was defined using sex-specific cut-off points other parameters by median values computed tomography imaging. Results: Among 96 patients, 40 had sarcopenia (43.0%) diagnosis. Body no effect 5-year disease-free survival contrary to classic factors (p<0.05). In subgroup obese...

10.21873/invivo.12115 article EN In Vivo 2020-01-01

BackgroundA surveillance program was performed in colorectal cancer (CRC) patients after surgery, to diagnose asymptomatic recurrence.AimsTo assess whether 18-FDG positron emission tomography/CT (PET/CT) improved the detection of recurrence during a 3-year follow-up.MethodsA multicentre, two-arm randomised prospective trial comparing different 36-month follow-up strategies. Complete colonoscopy at baseline and 3 years clinical exams with imaging every months. The conventional arm (A)...

10.1016/j.dld.2020.10.012 article EN cc-by-nc-nd Digestive and Liver Disease 2020-11-02

La consultation d'annonce en oncologie médicale est une situation particulièrement stressante tant pour le patient que médecin. simulation haute-fidélité option d'apprentissage jamais évaluée France dans ce domaine. Il s'agit d'un retour d'expérience de simulations consultations réalisées janvier 2018 à mai 2019. Les internes d'onco-radiothérapie ont réalisé d'une avec infirmière, un psychologue, coach certifiée et oncologue. L'évaluation des compétences l'annonce a été faite par pré-test...

10.1016/j.bulcan.2020.02.007 article FR cc-by-nc-nd Bulletin du Cancer 2020-03-31

Abstract Oral therapies have highly modified cancer patient management and changed hospital practises. We introduce a specific Therapy Centre retrospectively review information prospectively recorded by co-ordination nurses (CNs) (the DICTO programme). describe the roles played CNs in of oral at Limoges Dupuytren Hospital between May 2015 June 2018. All cancers, irrespective stage or whether general chemotherapy targeted therapy was prescribed, are included. followed up 287 patients median...

10.1007/s12032-020-01393-7 article EN cc-by Medical Oncology 2020-07-25

Metastasis from primary cancer to the thyroid is uncommon in breast cancer. Here we present a case of lobular carcinoma that metastasized thyroid. A 54-year-old woman without symptoms was admitted our institution for staging lymph node above left clavicle. An 18F-fluoro-deoxy-D-glucose positron emission tomography scan performed staging, and low uptakes were observed supraclavicular cervical nodes. High uptake seen posterior lower lobe Histologic findings indicated (positive GATA3, loss...

10.4048/jbc.2018.21.e55 article EN cc-by-nc Journal of Breast Cancer 2018-01-01

Glioblastoma is the most common form of primary brain cancer. Its treatment involves surgery, radiotherapy, and chemotherapy with temozolomide (TMZ), which an oral alkylating agent. To best our knowledge, few dermatologic side effects TMZ have been described. We report two cases cutaneous drug eruption caused by during after radiochemotherapy treatment. In first case, all tests were negative, but clinical history time onset supported allergy to TMZ. second was proved a positive lymphocyte...

10.3747/co.21.2133 article EN cc-by Current Oncology 2014-12-01

Abstract DNA topoisomerase I (Topo I) is involved in replication, transcription, recombination and repair. Clinical interest has focused on Topo as it the molecular target of camptothecin (CPT), used first second lines treatment for different cancer types. Furthermore, well demonstrated that patients who best responded to CPT-based chemotherapy were generally those with greatest tumoral expression and/or activity. We developed a sensitive, simple reproducible method measure mRNA human...

10.1515/cclm.2005.120 article EN Clinical Chemistry and Laboratory Medicine (CCLM) 2005-01-01

The objective of this study was to compare the efficacy biomarkers in assessing risk breast cancer recurrence patients with node-negative or micrometastatic grade II cancer. Specifically, we compared assessments based on St. Gallen clinicopathological criteria, Ki67 expression and urokinase plasminogen activator (uPA)/plasminogen inhibitor-1 (PAI-1) expression. This retrospective included 347 followed at Limoges University Hospital. optimal cut-off for high (Ki67hi) established as 20%....

10.1186/s12885-017-3648-z article EN cc-by BMC Cancer 2017-09-27

Background: Adapted physical activity (APA) aids breast cancer patients. It is necessary to use an adapted target heart rate (HR) when prescribing exercise intensity. Methods: In total, 138 patients previously included in two published randomized clinical trials underwent the CPET and 6MWT before after adjuvant therapy. Of these patients, 85 had performed APA, 53 received only usual HRs were recorded during tests. Results: Before starting chemotherapy, good agreement (intraclass correlation...

10.3390/cancers13225851 article EN Cancers 2021-11-22

<title>Abstract</title> <bold>Purpose:</bold> Recent developments in oral chemotherapy and targeted therapies have radically changed the way which cancer patients are managed. Ambulatory care is now common, associated with development of organizations that foster, secure home treatments, reinforce city hospital link. <bold>Methods: </bold>THERANOVA-LIM (NCT04931329), a prospective, interventional study, assessed satisfaction healthcare professionals who benefited from improved access to...

10.21203/rs.3.rs-3890177/v1 preprint EN cc-by Research Square (Research Square) 2024-01-31

L'intervention d'infirmières de pratiques avancées (IPA) est toute nouvelle en cancérologie. Son impact dans la prise charge du cancer sein actuellement très peu évalué ainsi que satisfaction des patients qu'elle prend charge. Cette étude prospective observationnelle a pour objectif recueillir le retour d'expérience pris par une IPA, fonction mode d'administration anti-HER2 (sous-cutanée versus intraveineux) et lieu (hospitalisation à domicile ou hôpital). Entre janvier 2022 juin 2023, 32...

10.1016/j.bulcan.2024.01.006 article FR cc-by-nc-nd Bulletin du Cancer 2024-03-12
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