Novel drug delivery systems are now a days is creating new interest in development of deliveries. Vesicular system also part these novel systems. TDDS the permeability skin, it permeable to small molecules, lipophilic and highly impermeable macromolecules hydrophilic drugs. Recent approaches have resulted design two vesicular carriers, ethosomes ultra flexible lipid based elastic vesicles, transferosomes. Transferosomes recently been introduced, which capable transdermal low as well high...

Abstract Background The pivotal intent of this study was to investigate the medicinal potential synthesized nanotransferosomes utilizing Clerodendrum serratum L. hydroalcoholic extract (CS-NTs). Three batches, CS-NTs 25, 50, and 100, were formulated using thin-film hydration approach with varying concentrations phospholipids (soya phosphatidylcholine) at 100 mg, respectively, evaluate their efficacy against skin cancer cell lines. Several analytical approaches, such as UV/Vis spectroscopy,...

Background: Anaplastic Lymphoma Kinase (ALK) is implicated in several cancers, including anaplastic large cell lymphoma, non-small lung cancer, and neuroblastoma. Targeted inhibition of ALK represents a promising therapeutic strategy. Aims: This study aimed to identify evaluate potential inhibitors using virtual screening computational analyses determine their binding stability, affinity, dynamic behavior, ultimately assessing as agents for ALK-driven cancers. Objective: The objective this...

A stability-indicating liquid chromatographic method has been developed and validated for the determination of Diltiazem Hydrochloride (DTZ) together with its six related substances (Diltiazem sulphoxide, Imp-A, Imp-B, Imp-D, Imp-E, Imp-F) in a laboratory mixture as well novel tablet formulation in-house. Efficient separation was achieved on Hypersil BDS C18 (150 mm×4.6 mm, 5.0 μm) mobile phase containing 0.2% Triethylamine (TEA) gradient combination acetonitrile (ACN) at flow rate 1.0...

To study the influence of methanolic and aqueous extract Withania somnifera (W. somnifera) root on marble-burying behavior mice a well-accepted model obsessive compulsive behavior.Mice were divided in different groups (n = 6). Fluoxetine (5, 10, 15 mg/kg), (10, 25, 50, 100 mg/kg) W. (MEWS) administered i.p. 30 min. prior to assessment marble burying locomotor activity. The control group received vehicle extract.Administration extracts (AEWS) MEWS (50 successively decreased activity without...

Delivery across skin is striking due to its easy convenience. However, drug delivery still a confront in biomedical sciences. Over the past few decades, various successful narrative devices and techniques have emerged optimize whose barricading behaviour constricts entry of most therapeutic agents. Ethosomes are non-invasive transporter that enables drugs reach deep layers and/or systemic circulation. Although ethosomal systems theoretically sophisticated, they characterized by simplicity...

<b>Introduction:</b> 1,2,4-triazoles and its derivatives have been reported to possess anti-inflammatory, analgesic, antimicrobial, anticancer, antitumor, antitubercular, anticonvulsant, openers of Ca-activated potassium (Maxi-K) channels, antiviral properties, hypoglycemic, anxiolytic antidepressant activity. Therefore, 1,2,4-triazole seems be an important pharmacophore. <b>Materials Methods:</b> The synthesis 4-(substituted ethanoyl) amino-3-mercapto-5-(4-methoxy) phenyl-1,2,4-triazoles...

Abstract In the present study, ZINC database has been used for virtual screening of thousand compounds based on previously reported pharmacophore against PIM‐1 kinase. These were further screened by Glide docking methodologies such as high throughput (HTVS), standard precision (SP) and extra (XP), kinase (PDB ID: 4DTK). Eight top‐ranked ZINC22066185, ZINC05678245, ZINC16431468 , ZINC05773728, ZINC36633741, ZINC16779084, ZINC19909862 ZINC15056464 selected studies. showed better binding...

The medicinal plants have enormous pharmacological properties with fewer side effects. Today, there is an increasing demand of as anti-aging and anti-wrinkle agent. ; Objective: aim this study to evaluate the antioxidant, potential Salvia officinalis. Materials Methods: officinalis (Lamiaceae) folk medicine Asia Latin America. Powdered crude drug 100 g was successively extracted in a soxhlet apparatus petroleum ether (60-80ºC), chloroform methanol. After successive solvents, extraction...

Target-specific drug-delivery systems for the administration of pharmaceutical compounds enable localization drugs to target sites within body. The basic component drug delivery is an appropriate carrier that protects from rapid degradation or clearance and thereby enhances concentration in tissues. Niosome are microscopic non-ionic surfactant bilayer vesicles obtained on hydration synthetic nonionic surfactants, with without incorporation cholesterol their lipids. amphiphilic nature...

The effects of ethanolic extracts whole plants Bacopa monnieri (BME), Evolvulus alsinoides (EAE), Tinospora cordifolia (TCE) and their combinations in equal proportion [CEP-1 (BME+EAE), CEP-2 (BME+TCE), CEP-3 (EAE+TCE) CEP-4 (BME+EAE+TCE)] were tested amnesic rats using Radial arm maze task performance (RAM) Barnes test at 200 mg/kg p.o. latency to find food target hole was observed RAM respectively. Cognitive dysfunction induced by scopolamine (0.3 i.p.) treatment. BME, EAE, TCE (CEPs)...

To research the acute toxicity of Illicium verum (I. verum) fruit extracts and its action on central nervous system.The TLC HPTLC techniques were used as fingerprints to determine chemical components present in I. verum. Male albino rats mice utilized for study. The powdered material was successively extracted with n-hexane, ethyl acetate methanol using a Soxhlet extractor. Acute studies performed per OECD guidelines. CNS activity evaluated parameters general behavior, sleeping pattern,...

The Jan Aushadhi Scheme (JAS) initiated by the Government of India is a powerful intervention against unjustifiable pricing medicines private pharmaceutical industry, to make generic available at affordable prices. marginalized populations are not able afford many branded medicines; hence, there an urgent need for making cheaper generics Indians in best interest populations. It has been observed that lack awareness public, distribution free state governments, support JAS, poor supply chain,...

Myrica nagi Hook (syn. esculenta Buch. & Ham) (Myricaceae) is commonly known as box berry. The bark of used in the treatment mental illness by different ethnic groups rural region Orissa (India). In present work, anxiolytic and antidepressant effects an ethanol extract M. were analyzed at three dosages (100, 200, 400 mg/kg, p.o.) elevated plus-maze, light/dark exploration test, tail suspension forced swimming model. Oral administration showed significant (p < 0.01) dose-dependent activity...

ABSTRACT Collective cell migration (CCM), in which cell–cell integrity remains preserved during movement, plays an important role the progression of cancer. However, studies describing CCM cancer are majorly focused on effects extracellular tissue components moving plasticity. The molecular and cellular mechanisms remain poorly explored. Here, we report that proteolipid protein 2 (PLP2), a colonic epithelium-enriched transmembrane protein, vital invasive human colorectal (CRC) epithelium by...