A5012824037- Marine and coastal plant biology
- Genetic diversity and population structure
- Coral and Marine Ecosystems Studies
- Marine Biology and Ecology Research
- Echinoderm biology and ecology
- Animal Genetics and Reproduction
- Genomics and Phylogenetic Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Marine Bivalve and Aquaculture Studies
- Spacecraft and Cryogenic Technologies
- Chromosomal and Genetic Variations
- Ocean Acidification Effects and Responses
- Influenza Virus Research Studies
- Crustacean biology and ecology
- Animal Disease Management and Epidemiology
- Respiratory viral infections research
- Animal Behavior and Reproduction
- Evolutionary Psychology and Human Behavior
National Institute of Allergy and Infectious Diseases
2025
National Institutes of Health
2025
Simon Fraser University
2017-2023
National Museum of Natural History
2019-2021
Smithsonian Institution
2019-2021
University of California, Merced
2021
Influenza virus pandemics and seasonal epidemics have claimed countless lives. Recurrent zoonotic spillovers of influenza viruses with pandemic potential underscore the need for effective countermeasures. In this study, we show that pre-exposure prophylaxis broadly neutralizing antibody (bnAb) MEDI8852 is highly in protecting cynomolgus macaques from severe disease caused by aerosolized pathogenic avian H5N1 infection. Protection was dose–dependent yet independent Fc-mediated effector...
Coevolution of genes that encode interacting proteins expressed on the surfaces sperm and eggs can lead to variation in reproductive compatibility between mates isolation members different species. Previous studies mice other mammals have focused particular evidence for positive or diversifying selection shapes evolution sperm-binding egg coat zona pellucida (ZP). By fitting phylogenetic models codon data from 1000 Genomes Project, we identified candidate sites evolving under human ZP3 ZP2 ....
The characterization of gene expression in gametes has advanced our understanding the molecular basis for ecological variation reproductive success and evolution isolation. These advances are especially significant ecologically important keystone predators such as coral-eating crown-of-thorns sea stars (COTS, Acanthaster) which most influential predator species Indo-Pacific coral reef ecosystems focus intensive management efforts. We used RNA-seq transcriptome assemblies to characterize...
Many sea stars are well known for facultative or obligate asexual reproduction in both the adult and larval life-cycle stages. Some species lineages also capable of hermaphroditic with self-fertilization. However, models population genetic variation empirical analyses data typically assume only sexual outcrossing. A recent reanalysis previously published (microsatellite genotypes) from two studies one most well-known star (the crown-of-thorns star; Acanthaster sp.) concluded that cloning...
Gamete compatibility, and fertilization success, is mediated by gamete-recognition genes (GRGs) that are expected to show genetic evidence of a response sexual selection associated with mating system traits. Changes in the strength can arise from resolution sperm competition among males, conflicts interest between males females, or other mechanisms selection. To assess these expectations, we compared patterns episodic diversifying expressed gonads Cryptasterina pentagona C. hystera, which...
Understanding the demographic context for population divergence and speciation in sea often requires distinguishing contributions of mutation, isolation, gene flow on temporal or geographical scales where those diverse processes may not achieve equilibrium conditions. Coalescent isolation-with-migration (IM) models can meet this need non-equilibrium modelling genetic variation, but quality IM model parameter estimation depends breadth genome sampling. Here, we describe three improvements...