A5052299753- Dementia and Cognitive Impairment Research
- Global Cancer Incidence and Screening
- Breast Cancer Treatment Studies
- Economic and Financial Impacts of Cancer
- Colorectal Cancer Screening and Detection
- Musculoskeletal pain and rehabilitation
- Gastric Cancer Management and Outcomes
- Breast Lesions and Carcinomas
- Aging and Gerontology Research
- Health disparities and outcomes
- Cerebrovascular and Carotid Artery Diseases
- HER2/EGFR in Cancer Research
- Multiple and Secondary Primary Cancers
- Non-Invasive Vital Sign Monitoring
- Spine and Intervertebral Disc Pathology
- Cancer Genomics and Diagnostics
- Identity, Memory, and Therapy
- Heart Rate Variability and Autonomic Control
- Pharmacological Effects and Toxicity Studies
- Acute Ischemic Stroke Management
- Urban Green Space and Health
- Frailty in Older Adults
- Chemotherapy-induced organ toxicity mitigation
- Dietary Effects on Health
- Moyamoya disease diagnosis and treatment
University of California, San Diego
2024-2025
Albert Einstein College of Medicine
2021-2024
Human Longevity (United States)
2024
Montefiore Medical Center
2021-2023
Background and Objective: Within-person variability in cognitive performance has emerged as a promising indicator of health with potential to distinguish normative pathological aging. We use smartphone-based digital approach ecological momentary assessments (EMA) examine differences among older adults mild impairment (MCI) those who were cognitively unimpaired (CU). Method: A sample 311 systematically recruited, community-dwelling from the Einstein Aging Study (Mean age = 77.46 years, SD...
Incremental delays in time to treatment initiation (TTI) have been shown cause a proportional, increased independent risk of disease-specific mortality for breast cancer, colorectal cancer (CRC), head and neck (HNC), non-small-cell lung (NSCLC), pancreatic cancer. Studies suggest that are associated with racial socioeconomic disparities. We evaluated associations between patient factors TTI identify those delay.This is retrospective cohort study at an urban community-based academic center...
Post-polypectomy colorectal cancers (PPCRCs) are diagnosed after a cancer-negative colonoscopy with polypectomy. Analyzing PPCRC characteristics informs prevention and early detection strategies. We investigated interval types etiologies of PPCRCs using World Endoscopy Organization (WEO) guidelines. were identified in retrospective cohort U.S. Veterans who underwent polypectomy 1999-2016. classified into interval, non-interval type A, B, defined as before, at, next recommended surveillance...
Abstract The 21-gene recurrence score (RS) is prognostic for and predictive of chemotherapy benefit in early estrogen receptor-positive (ER +) HER2-negative (HER2-) breast cancer (BCA). We evaluated clinicopathologic characteristics, RS invasive ductal carcinoma (IDC), lobular (ILC), carcinomas mixed histologies (ductal + (DLC), other (DOC), (LOC)). Women diagnosed between 1/1/2010 1/1/2014 with ER HER2- BCA, measuring < 5 cm, 0–3 involved axillary nodes, surgery as first treatment,...
Black, compared to white, women with residual estrogen receptor-positive (ER+) breast cancer after neoadjuvant chemotherapy (NAC) have worse distant recurrence-free survival (DRFS). Such racial disparity may be due difference in density of portals for systemic cell dissemination, called TMEM doorways, and pro-metastatic tumor microenvironment (TME). Here, we evaluate specimens NAC from 96 Black 87 white women. doorways are visualized by triple immunohistochemistry, stem cells...
Background Black race is associated with worse outcome in patients breast cancer. The distant relapse‐free survival (DRFS) between and White women localized cancer who participated National Cancer Institute–sponsored clinical trial was evaluated. Methods Pooled data were analyzed from 8 Surgical Adjuvant Breast Bowel Project (NSABP) trials including 9702 treated adjuvant chemotherapy (AC, n = 7485) or neoadjuvant (NAC, 2217), self‐reported as (n 1070) 8632) race. association DRFS using...
Abstract Objective: Research examining (MCI) criteria in diverse and/or health-disparate populations is limited. There a critical need to investigate the predictive validity for incident dementia of widely used MCI definitions populations. Method: Eligible participants were non-Hispanic White or Black Bronx community residents, free at enrollment, with least one annual follow-up visit after baseline. Participants completed neurological and neuropsychological evaluations determine cognitive...
Background: The Uniform Data Set, Version 3 Neuropsychological Battery (UDSNB3.0), from the database of University Washington’s National Alzheimer’s Coordinating Center (NACC), is widely used to characterize cognitive performance in clinical and research settings; however, norms for underrepresented community-based samples are scarce. Objective: We compared UDSNB 3.0 test scores between Einstein Aging Study (EAS), composed racially/ethnically diverse, community-dwelling older adults aged≥70...
Abstract Background Subjective cognitive concerns (SCC) play an important role in the identification of preclinical dementia, especially among individuals who have experienced health disparities. It is critical to discern differential patterns SCC endorsement racially/ethnically diverse groups enhance ability accurately capture current and future status. Moreover, it determine whether association SCCs objective neuropsychological test scores vary by racial/ethnic background. Method Using...
Abstract Objective Episodic memory loss, a hallmark symptom of Alzheimer’s Disease, is frequently quantified by story performance. The National Coordinating Center Uniform Data Set Neuropsychological Battery (UDSNB) replaced Logical Memory with Craft Story 21 in UDSNB Version 3. concordance between these tasks poorly characterized demographically diverse older adults, possibly jeopardizing the integrity longitudinal data aging cohorts. Method Einstein Aging Study participants (n = 298; Mage...
Abstract Background: Black, compared to White women with localized breast cancer have higher mortality and worse distant recurrence free survival (DRFS). This has been attributed social determinants of health prevalence triple negative (TNBC) in Black women. Recent studies indicate that racial disparity outcome is present patients estrogen receptor-positive (ER+), but not ER- disease, particular residual disease after neoadjuvant chemotherapy (NAC). It shown some NAC may induce...
<h3>BACKGROUND AND PURPOSE:</h3> Intracranial aneurysms have a reported prevalence of 1%–2% in the general population. Currently, only patients with strong family history or autosomal dominant polycystic kidney disease are screened for intracranial using MRA. The purpose this study was to determine whether there other specific patient populations at risk that should be offered screening aneurysms. <h3>MATERIALS METHODS:</h3> This is retrospective case-control adult who underwent MRA their...
Abstract The immune system has been described to play a role in the development of Alzheimer’s disease (AD), but distribution immunoglobulins and their subclasses brain tissue not explored. In this study, examination pathologically diagnosed frontal cortex gray matter revealed significantly higher levels IgM IgG late-stage AD (Braak Braak stages V VI) compared age-matched controls. While IgG2 IgG4 constant region fragments were AD, concentration native–state with free Fc regions was...
Abstract Background The role of autonomic function in cognitive impairment is unclear. Heart rate variability (HRV) provides a feasible, non‐invasive measure cardiac control. We examined whether HRV associated with global cognition and using 7‐day ambulatory ECG assessments the Einstein Aging Study. Method Analyses included 84 participants free dementia (mean age 78.1 (± 5.2) years; 82% female; 39% non‐Hispanic White, 44% Black, mean education 14.7 3.3 years)). Participants wore small,...
Chronic back and leg pain are leading causes of disability worldwide. The purpose this study was to compare the care in a unidisciplinary (USC) versus multidisciplinary (MSC) spine clinic, where patients evaluated by different specialists during same office visit. Adult presenting with chief complaint and/or between June 2018 July 2019 were assessed for eligibility. main outcome measures included first treatment recommendations, time order, occurrence. A 1:1 propensity score-matched analysis...
17 Background: Cancer diagnosis, staging work up and treatment need to be done in a timely manner but are rarely emergencies. during hospital admission is costly can take away resources that needed for more urgent patients. We aim understand factors related cancer the inpatient setting. Methods: Patients with new diagnosis of colon at single academic institution 2018 were identified using registry. excluded if they had other than carcinoma or data on half their was not available review. A...
Abstract Background: The Oncotype DX 21-gene expression assay (ODX) is prognostic for recurrence and predictive of chemotherapy benefit in early estrogen receptor-positive (ER+) HER2-negative (HER2-) breast cancer (BCA). Invasive ductal carcinoma (IDC) comprises approximately 80% BCA. lobular (ILC) a subtype BCA with distinct pathologic features, often has low to intermediate ODX Recurrence Score (RS). We evaluated differences clinicopathologic characteristics, RS between IDC, ILC,...
Introduction Heart rate variability (HRV) reflects the activity of autonomic nervous system (ANS) and can be used as a potential predictor stress-related cardiovascular diseases. This study aimed to assess whether physical mental strain during performance cerebral endovascular procedure influence time-domain HRV parameters in operating surgeon. Materials Methods (HR) metrics were measured using HR sensor chest strap before, during, after neuroendovascular interventions performed by single...
Abstract Background Measurement burst designs, using ambulatory cognitive assessments facilitate the dissociation of retest effects from optimal (“asymptotic”) performance. Dissociating these features via process modeling may reveal indices subtle impairment that signal risk for neurocognitive decline. We investigated cross‐sectional associations between plasma NfL (a biomarker neurodegeneration), improvements, and performance on Symbol Match task, which assesses processing speed by response...