A5079074364- Diet and metabolism studies
- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Gut microbiota and health
- Thyroid Cancer Diagnosis and Treatment
- Nuclear Structure and Function
- Nutrition, Genetics, and Disease
- Genetic Associations and Epidemiology
- Viral Infections and Immunology Research
- Hepatitis B Virus Studies
- Forensic and Genetic Research
- Bacteriophages and microbial interactions
- Ion channel regulation and function
- Nutritional Studies and Diet
- Trace Elements in Health
- COVID-19 Impact on Reproduction
- Cancer-related gene regulation
- Celiac Disease Research and Management
- ECG Monitoring and Analysis
- BRCA gene mutations in cancer
- Bariatric Surgery and Outcomes
- Genetic factors in colorectal cancer
- Liver Diseases and Immunity
- Gestational Diabetes Research and Management
- Nuclear Receptors and Signaling
Universidad UTE
2022-2025
Instituto de Investigación Geológico y Energético
2019
Obesity, a chronic global health problem, is associated with an increase in various comorbidities, such as cardiovascular disease, type 2 diabetes mellitus, hypertension, and certain types of cancer. The increasing prevalence obesity requires research into new therapeutic strategies. Glucagon-like peptide-1 receptor agonists, specifically semaglutide liraglutide, designed for mellitus treatment, have been explored drugs the treatment obesity. This minireview describes molecular mechanisms...
Cardiovascular diseases (CVDs) are the leading global cause of mortality, with South America reflecting similar trends. Among congenital heart (CHDs), atrioventricular (AV) block is included. AV a condition defined by abnormal electrical signal transmission between atria and ventricles. Advances in Next-Generation Sequencing (NGS) have facilitated identification genetic variants associated cardiac disorders, such as block. Notably, transcription factor NKX2-5 plays crucial role development...
Introduction Long QT syndrome (LQTS) is an autosomal dominant inherited cardiac condition characterized by a interval prolongation and risk of sudden death. There are 17 subtypes this associated with genetic variants in 11 genes. The second most common type 2, caused mutation the KCNH2 gene, which part potassium channel influences final repolarization ventricular action potential. This case report presents Ecuadorian teen congenital Syndrome 2 (OMIM ID: 613688), from family without diseases...
Cardiovascular diseases (CVDs) are the leading cause of death worldwide across diverse ethnic groups. Among these, atrial fibrillation (AF) stands as one most prevalent types arrhythmias and primary stroke. Risk factors associated with AF include alcohol consumption, aging, high blood pressure, hypertension, inflammation, genetic factors. A family history CVD could indicate an increased risk. Consequently, genetic, genomic testing should be performed to identify molecular etiology CVDs...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by widespread inflammation and organ damage. Studies indicate that diet significantly influences the gut microbiota, which, in turn, affects immune system. This article explores microbiota dysbiosis SLE patients potential mechanisms related to dietary interventions function. It highlights specific patterns, such as high-fibre Mediterranean diet, may modulate diversity activity of microbiota. The interaction...
Introduction Cardiac laminopathies are caused by mutations in the LMNA gene and include a wide range of clinical manifestations involving electrical mechanical changes cardiomyocytes. In Ecuador, cardiovascular diseases were primary cause death 2019, accounting for 26.5% total deaths. laminopathy-associated involve genes coding structural proteins with functions related to heart development physiology. Family description Two Ecuadorian siblings, self-identified as mestizos, diagnosed cardiac...
Introduction Genomic screening is an informative and helpful tool for the clinical management of inherited conditions such as cardiac diseases. Cardiac-inherited diseases are a group disorders affecting heart, its system, function, vasculature. Among abnormalities, one most common Wolff-Parkinson-White syndrome. Similarly, hypertrophic cardiomyopathy another autosomal dominant disease. Hypertrophic associated with increased incidence syndrome; reports have suggested that it could be caused...
Coronavirus Disease 2019 (COVID-19) is a severe respiratory illness caused by the RNA virus SARS-CoV-2. Globally, there have been over 759.4 million cases and 6.74 deaths, while Ecuador has reported more than 1.06 35.9 thousand deaths. To describe COVID-19 pandemic impact vaccinations effectiveness in low-income country like Ecuador, we aim to assess seroprevalence of IgG IgM antibodies against SARS-CoV-2 sample from healthy blood donors at Cruz Roja Ecuatoriana.
Abstract Background Ion channels, vital transmembrane protein complexes, regulate ion movement within cells. Germline variants in channel-encoding genes lead to channelopathies. The sodium channels cardiac cells exhibit a structure of an alpha subunit and one two beta subunits. subunit, encoded by the SCN5A gene, comprises four domains. Case presentation A fifteen-year-old Ecuadorian female with atrial flutter abnormal sinus rhythm no familial history cardiovascular disease underwent NGS...
In 1993, the science historian Margaret
Cardiac pathologies are among the most frequent causes of death worldwide. Regarding cardiovascular deaths, it is estimated that 5 million cases caused by sudden cardiac (SCD) annually. The primary cause SCD ventricular arrhythmias. Genomic studies have provided pathogenic, likely and variants uncertain significance may predispose individuals to death. In this study, we describe case a 43-year-old individual who experienced an episode aborted SCD. An implantable cardioverter defibrillator...