ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvolysis rates and deuterium isotope effects in 2,2,2-trifluoroethanol-water mixturesVernon J. Shiner Jr., William Dowd, Robert Dowling Fisher, S. R. Hartshorn, M. A. Kessick, Louis Milakofsky, W. RappCite this: Am. Chem. Soc. 1969, 91, 17, 4838–4843Publication Date (Print):August 1, 1969Publication History Published online1 May 2002Published inissue 1 August...

The optical and biological properties of BODIPY their interactions with diverse DNA forms were studied. dyes 1 3 interact more preferably tetraplexes than other forms, the tendency to destabilize parallel c- MYC G-quadruplex.

Abstract To survive and grow, plant cells must regulate the properties of their cellular microenvironment in response to ever changing external factors. How biomechanical balance across cell’s internal structures is established maintained during environmental variations remains a nurturing question. provide insight into this issue we used two micro-mechanical imaging techniques, namely Brillouin light scattering BODIPY-based molecular rotors Fluorescence Lifetime Imaging, study Nicotiana...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT.alpha.-Deuterium effects in SN2 reactions with solventVernon J. Shiner Jr., M. W. Rapp, and H. R. Pinnick Jr.Cite this: Am. Chem. Soc. 1970, 92, 1, 232–233Publication Date (Print):January 1970Publication History Published online1 May 2002Published inissue 1 January 1970https://pubs.acs.org/doi/10.1021/ja00704a056https://doi.org/10.1021/ja00704a056research-articleACS PublicationsRequest reuse permissionsArticle Views323Altmetric-Citations21LEARN...

Direct conversion of the α-hydroxyl group by

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvolytic .alpha.-deuterium effects for different leaving groupsVernon J. Shiner Jr., M. W. Rapp, Emil A. Halevi, and Max WolfsbergCite this: Am. Chem. Soc. 1968, 90, 25, 7171–7172Publication Date (Print):December 1, 1968Publication History Published online1 May 2002Published inissue 1 December 1968https://pubs.acs.org/doi/10.1021/ja01027a075https://doi.org/10.1021/ja01027a075research-articleACS PublicationsRequest reuse permissionsArticle...

A new reaction of the efficient difluorocarbene-generating reagent trimethylsilyl fluorosulfonyldifluoroacetate (TFDA) is reported in which molecules containing an N-alkylimidazole or benzimidazole structure undergo unexpected one-pot conversion to N-difluoromethylthioureas.

Treatment of the 6-N-cyclopropyl-2',3'-di-O-isopropylideneadenosine 5'-aldehyde with sulfone-stabilized phosphonate or fluorophosphonate reagents followed by stannyldesulfonylations and subsequent iodo- protiodestannylation gave 6-N-cyclopropyl-5'-deoxy-5'-(iodomethylene)adenosine 8b its 5'-fluoromethylene analogue 11. hydroxylamine dibromomethylene- cyanomethylene-stabilized Wittig deprotections oxime 4b, 5'-cyanomethylene 5b, 5'-dibromomethylene 13b analogues. Dehydrobromination acetylenic...

The trifluoromethyl group placed in the α position to CO impacts conformation around F–C–CO bond.

Transformations of α-hydroxyphosphonates derived from proline or serine by treatment with different deoxyfluorinating reagents (DAST, Deoxofluor, PyFluor) are reported. Depending on the applied reagent, as well protecting group used (N-Cbz, N-Boc, N-Bn) types products observed. The reaction N-Cbz N-Boc prolinols DAST Deoxofluor due to aziridinium intermediate participation gave fluorinated amino phosphonates such piperidine and pyrrolidine derivatives and/or oxazolidine-2-ones. Similarly,...

Herein, we described the efficient and straightforward synthesis of<italic>N</italic>-substituted α,α-difluoro-β-aminophosphonates with use of electrophilic fluorination by Selectfluor®.

The goal of this review is to describe recent advances in metal catalyzed reactions and organocatalysis leading α-monofluoro-, α,α-gem-difluoro- or trifluoromethyl phosphonate derivatives with a particular emphasis on introducing chiral centers these compounds. Keywords: Asymmetric catalysis, fluorinated phosphonate, fluorination, phosphonylation, organocatalysis, organometallics catalysis.

The synthesis of the stable surrogates an important amino acid ( R )-4-amino-3-hydroxybutyric (GABOB) such as substituted hydroxy aminophosphonic acids bearing a quaternary stereogenic center is presented. Highly diastereoselective formations fluorinated spiroepoxy alkylphosphonate or related tertiary carbon-containing oxiranes from β-keto phosphonates possessing methyl, phenyl, cyclohexenyl substituents, are reported. Stereoselective acid-promoted epoxide opening by bromide azide followed...

Abstract To survive and grow, plant cells must regulate the properties of their cellular microenvironment in response to ever changing external factors. How biomechanical balance across cell’s internal structures is established maintained during environmental variations remains a nurturing question. provide insight into this issue we used two micro-mechanical imaging techniques, namely Brillouin light scattering BODIPY-based molecular rotors Fluorescence Lifetime Imaging, study Nicotiana...

The efficient one-pot halofluorination of a