A5088825287- Zebrafish Biomedical Research Applications
- Neurobiology and Insect Physiology Research
- Physiological and biochemical adaptations
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Neuroendocrine regulation and behavior
- Adipose Tissue and Metabolism
- Fish biology, ecology, and behavior
- Muscle activation and electromyography studies
- Animal Vocal Communication and Behavior
- Ion channel regulation and function
- Sleep and Wakefulness Research
- Amphibian and Reptile Biology
- Neuroscience of respiration and sleep
- Bat Biology and Ecology Studies
- Nerve Injury and Rehabilitation
- Circadian rhythm and melatonin
- Child and Animal Learning Development
- Marine animal studies overview
- Memory and Neural Mechanisms
- Neurogenetic and Muscular Disorders Research
- Robotic Locomotion and Control
- Olfactory and Sensory Function Studies
- Decision-Making and Behavioral Economics
- Effects of Environmental Stressors on Livestock
Karolinska Institutet
2016-2025
University of St Andrews
2012-2018
Proprioception is essential for behavior and provides a sense of our body movements in physical space. Proprioceptor organs are thought to be only the periphery. Whether central nervous system can intrinsically its own movement remains unclear. Here we identify segmental organ proprioception adult zebrafish spinal cord, which embedded by intraspinal mechanosensory neurons expressing Piezo2 channels. These cells late-born, inhibitory, commissural with unique molecular physiological profiles...
The flexibility of locomotor movements requires an accurate control their start, duration, and speed. How brainstem circuits encode convey these parameters remains unclear. Here, we have combined in vivo calcium imaging, electrophysiology, anatomy, behavior adult zebrafish to address questions. We reveal that the detailed are encoded by two molecularly, topographically, functionally segregated glutamatergic neuron subpopulations within nucleus medial longitudinal fasciculus. changes...
Ubiquitously expressed sodium pumps are best known for maintaining the ionic gradients and resting membrane potential required generating action potentials. However, activity- state-dependent changes in pump activity can also influence neuronal firing regulate rhythmic network output. Here we demonstrate that locomotor networks spinal cord of neonatal mice. The inhibitor, ouabain, increased frequency decreased amplitude drug-induced bursting, effects were dependent on presence neuromodulator...
While the inflammatory processes in rheumatoid arthritis have been described, mechanisms driving pain are poorly defined. Here, we used a multitude of approaches to uncover neural basis, mediators, intracellular signaling pathway and mechanism pain. In cartilage autoantibody-induced mice, an early immune-activation cytokine storm were mainly driven by vascular cells monocyte/macrophages dorsal root ganglion. However, persistently elevated interferons receptor-activation MNK1/2-eIF4E at all...
Abstract Activity-dependent modification of neural network output usually results from changes in neurotransmitter release and/or membrane conductance. In Xenopus frog tadpoles, spinal locomotor is adapted by an ultraslow afterhyperpolarization (usAHP) mediated increase Na + pump current. Here we systematically explore how the interval between two swimming episodes affects second episode, which shorter and slower than first episode. We find firing reliability rhythmic neurons to be lower...
Locomotion relies on the coordinated activity of rhythmic neurons in hindbrain and spinal cord depends critically intrinsic properties excitatory interneurons. Therefore, understanding how ion channels sculpt these interneurons, consequences for circuit function behavior, is an important task. The hyperpolarization-activated cation current, Ih, known to play roles shaping neuronal rhythm generation many networks. We show stage 42 Xenopus laevis frog tadpoles that Ih strongly expressed only...
Abstract Dopamine plays important roles in the development and modulation of motor control circuits. Here we show that dopamine exerts potent effects on central pattern generator circuit controlling locomotory swimming post-embryonic Xenopus tadpoles. (0.5–100 μM) reduced fictive swim bout occurrence caused both spontaneous evoked episodes to become shorter, slower weaker. The D2-like receptor agonist quinpirole mimicked this repertoire inhibitory swimming, whilst D4 antagonist, L745,870,...
During development, all animals undergo major adaptations to accommodate behavioral flexibility and diversity. How these are reflected in the changes motor circuits controlling our behaviors remains poorly understood. Here, we show, using a combination of techniques applied at larval adult zebrafish stages, that pattern-generating V0d inhibitory interneurons within locomotor circuit developmental switch their role. In larvae, show have primary function high-speed behavior yet redundant for...
Dynamic neuronal Na+/K+ pumps normally only respond to intense action potential firing owing their low affinity for intracellular Na+. Recruitment of these Na+ produces a post-activity ultraslow afterhyperpolarization (usAHP) up ∼10 mV in amplitude and ∼60 s duration, which influences properties future network output. In spinal motor networks, the usAHP underlies short-term memory (STMM), reducing intensity duration locomotor output manner dependent on interval between bouts. contrast...
Abstract Mutations in the gene encoding alpha3 Na+/K+-ATPase isoform (ATP1A3) lead to movement disorders that manifest with dystonia, a common neurological symptom many different origins, but for which underlying molecular mechanisms remain poorly understood. We have generated an ATP1A3 mutant mouse displays motor impairments and hyperexcitable phenotype compatible dystonia. show neurons harboring this mutation are compromised their ability extrude raised levels of intracellular sodium,...