A5072359237- Legionella and Acanthamoeba research
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Bacterial biofilms and quorum sensing
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Antifungal resistance and susceptibility
- Viral Infections and Vectors
- Antibiotic Resistance in Bacteria
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Imaging and Diagnostics
- Medical Imaging and Pathology Studies
- Infectious Diseases and Tuberculosis
- Colorectal Cancer Treatments and Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Psoriasis: Treatment and Pathogenesis
- Diagnosis and treatment of tuberculosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- RNA modifications and cancer
- Advanced Glycation End Products research
- Immunotherapy and Immune Responses
- Bacillus and Francisella bacterial research
- Bone health and treatments
University of the Ryukyus
2009-2025
Cardiovascular Center Hokkaido Ohno Hospital
2022-2024
University of the Ryukyus University Hospital
2008-2022
National Cancer Center
2011
Otsuka (Japan)
2001-2005
Nagasaki University
1999-2005
National Institute of Infectious Diseases
2005
Osaka International University
2005
Osaka City University
2005
Highlights•In Okinawa, the timing of RSV epidemic shifted during COVID-19 pandemic•The correlation between and its directionality varied by year•Climate may have had more impact than mobility on incidence pandemic•Lack human migration led to an from indigenous endemic strain•Our findings could guide programs for control vaccinationABSTRACTObjectivesThe coronavirus disease (COVID-19) pandemic affected respiratory syncytial virus (RSV) patterns. However, effects climatic virological factors...
An association between coronavirus disease 2019 (COVID-19) and concomitant varicella-zoster virus (VZV) reactivation has been proposed. We herein report a case of severe VZV pneumonia in 73-year-old man who underwent corticosteroid tapering after recovering from COVID-19 presented with fever, vesicular rashes, hypoxemia. Chest computed tomography (CT) revealed ground-glass opacities multiple granular shadows. Varicella-zoster was detected the skin bronchoalveolar lavage fluid. The patient...
Thymic carcinoma is a rare cancer of the thymus, different from thymoma in respect its malignant nature, and no standard chemotherapy for this has been established yet.We conducted retrospective review efficacy combination with carboplatin (an area under curve 6) paclitaxel (200 mg/m(2)) 16 patients histologically or cytologically proven thymic carcinoma, Masaoka Stage IVa/IVb post-operative recurrent disease.There were 13 males 3 females, median (range) age 56 (38-73) years. Squamous cell...
To evaluate the clinical implications of additional pedal artery angioplasty (PAA) for patients with critical limb ischemia (CLI).Twenty-nine (mean age 77.8±8.6 years; 21 men) CLI (32 limbs) presenting de novo infrapopliteal and (Kawarada type 2/3) disease were reviewed. The need PAA was based on existence sufficient wound blush (WB) around target wounds after conventional above-the-ankle revascularization. Fourteen insufficient WB in 14 limbs received PAA, while 15 18 did not. groups...
A novel DNA-binding protein expressed (8-10% in total protein) Mycobacterium bovis bacillus Calmette-Guérin was observed. This designated mycobacterial 1 (MDP1). MDP1 recognized bases, sugar moieties, phosphate-backbone on DNA and preferentially bound to guanine cytosine. In the gel retardation assay, closed circular plasmid than open linear form also RNA. formed a highly polymerized structure localized not only nucleoid but at 50S ribosomal subunits cell surface. conserved thus far examined...
We herein describe the case of a 63-year-old man who died from relapsed epidermal growth factor receptor gene (EGFR) exon 19 deletion lung adenocarcinoma treated with erlotinib. According to autopsy results, he was confirmed have small cell carcinoma without EGFR T790M mutation in his pancreas and left kidney metastatic specimens, while lesion right had mutation; both retained somatic deletion. report an resistance tyrosine kinase inhibitor via transformation EGFRT790M separate organs.
Pathogenic species of Mycobacterium are slowly growing intracellular bacteria. Slow growth is important for the parasitism these organisms and chronicity disease, but its precise mechanism has not been elucidated. Recently, we found that a novel DNA-binding protein (MDPI) was expressed (7-10% in total protein) mycobacteria, such as bovis bacillus Calmette-Guérin, tuberculosis, leprae. In this study, observed MDPI interfered with replication, transcription, translation analysis vitro E. coli...
Abstract Mycobacterium consists up to 7% of mycobacterial DNA-binding protein 1 (MDP1) in total cellular proteins. Host immune responses MDP1 were studied mice explore the antigenic properties this protein. Anti-MDP1 IgG was produced after infection with either bacillus Calmette-Guérin or tuberculosis C3H/HeJ mice. However, level Ab remarkably low when purified injected. is considered be associated DNA nucleoid, which contains immunostimulatory CpG motif. Therefore, we examined...
Legionella pneumophila pneumonia often exacerbates acute lung injury (ALI) and respiratory distress syndrome (ARDS). Apoptosis of alveolar epithelial cells is considered to play an important role in the pathogenesis ALI ARDS. In this study, we investigated precise mechanism by which A549 induced L. undergo apoptosis. We also studied effect methyl prednisolone on apoptosis these cells. Nuclear deoxyribonucleic acid (DNA) fragmentation caspase activation pneumophila-infected were assessed...
A 42-year-old man was admitted to our hospital with a history of fever, headache and disorientation. His cerebrospinal fluid revealed eosinophilia his serum had an antibody against Angiostrongylus cantonensis (A. cantonensis). Then, he diagnosed as eosinophilic meningoencephalitis caused by A. cantonensis. He treated repeated lumbar punctures oral prednisolone. Although symptom been suffering from at the time admission urinary retention, this disappeared general condition improved. Therefore...
Hepatocyte growth factor (HGF) is known to be involved in the resolution of pulmonary inflammation and repair acute lung injury. Legionella pneumonia sometimes complicated by Our study aimed determine role serum HGF levels pneumonia. Sera from patients with (42 cases), other bacterial (33 tuberculosis (19 normal controls (29 cases) were collected. The for each sample determined sandwich ELISA. Clinical laboratory data collected reviewing medical charts. Serum higher than those pneumonia,...
Abstract Hypertrophic pulmonary osteoarthropathy (HPOA) is a rare paraneoplastic syndrome. Our literature review shows the location of arthralgia and existence edema are referable information for differential diagnosis in arthralgia.
Interleukin (IL)-17A affects the immune system of lung. Legionella infection can potentially lead to severe pneumonia. The present study aimed evaluate role IL-17A in Serum levels were quantified both patients with pneumonia and control subjects; IL-17 was detected sera from 4 out 31 but any controls. There no differences peripheral white blood cell counts or other serum biomarkers (C-reactive protein, lactate dehydrogenase) between IL-17A-positive IL-17A-negative patients. All this cohort...
Drug-coated balloon (DCB) angioplasty has emerged as an effective treatment option for
The aim of the present study was to examine immunohistological characteristics disseminated Mycobacterium avium infection after initiation antiretroviral therapy (ART) for acquired immunodeficiency syndrome (AIDS).We histologically investigated five autopsied AIDS patients with systemic M. infection.The inflammatory cell composition in affected tissues assessed using immunohistochemistry. celiac lymph nodes and intestinal canal were most commonly involved organs cases. common histological...