A5071472752- Chronic Myeloid Leukemia Treatments
- Eosinophilic Disorders and Syndromes
- Reproductive Biology and Fertility
- Ovarian function and disorders
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Chronic Lymphocytic Leukemia Research
- Fungal Plant Pathogen Control
- Endometriosis Research and Treatment
- Renal and related cancers
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Uterine Myomas and Treatments
- Cervical Cancer and HPV Research
- Circular RNAs in diseases
- Reproductive Health and Technologies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pancreatic function and diabetes
- Cancer-related molecular mechanisms research
- Pregnancy-related medical research
- Biochemical and Structural Characterization
- Mast cells and histamine
- RNA modifications and cancer
- Plant Genetic and Mutation Studies
Universiti Sains Islam Malaysia
2018-2024
National University of Malaysia
2016-2023
University of Minnesota
2023
University of the Ryukyus
2023
University Kebangsaan Malaysia Medical Centre
2016-2018
Hospital Universiti Sains Malaysia
2017
Universiti Sains Malaysia
2011-2016
Development of resistance to imatinib mesylate (IM) in chronic myeloid leukemia (CML) patients has emerged as a significant clinical problem. The observation that increased epigenetic silencing potential tumor suppressor genes correlates with disease progression some CML treated IM suggests relationship between and development. We hypothesize promoter hypermethylation HOXA4 could be an mechanism mediating patients. Thus study was undertaken investigate the status on treatment determine its...
There is a lack of non-invasive screening modalities to diagnose chronic atrophic gastritis (CAG) and intestinal metaplasia (IM). Thus, the aim present study was determine sensitivity specificity serum pepsinogen I (PGI), PGI:II, PGI:II ratio gastrin-17 (G-17) in diagnosing CAG IM, correlations between these biomarkers pre-malignant gastric lesions. A cross-sectional 72 patients (82% calculated sample size) who underwent oesophageal-gastro-duodenoscopy for dyspepsia performed study. The mean...
Development of resistance to imatinib mesylate (IM) in chronic myeloid leukemia (CML) patients is mediated by different mechanisms that can be classified as BCR-ABL dependent or independent pathways. are most frequently associated with point mutations tyrosine kinase domain (TKD) BCR-ABL1 and also gene amplification. Many types frequencies have been reported studies, probably due the composition study cohorts. Since no reports available from Malaysia, this was undertaken investigate...
Fragile X Syndrome (FXS) is the most common form of inherited mental retardation in men. It caused by abnormalities FMR1 gene that are associated with CGG repeat expansion and hypermethylation status its promoter. Methylated alleles lead to transcriptional inhibition consequent loss Mental Retardation Protein. Chemical modification cytosine uracil bisulfite treatment has proved be an attractive method for DNA methylation studies precludes labor-intensive Southern blot analysis, which gold...
Abstract Background Imatinib mesylate is a molecularly targeted tyrosine kinase inhibitor drug. It effectively used in the treatment of chronic myeloid leukemia (CML) patients. However, development resistance to imatinib as result BCR‐ABL dependent and independent mechanisms has emerged daunting problem management CML Between these mechanisms, are still not robustly understood. Aim To investigate correlation HOXA4 HOXA5 promoter DNA hypermethylation with among Methods results Samples from...
RNA extraction from human cumulus cells (CCs) is considered challenging due to low cell’s pop-ulation and small cell. The successful gene expression analysis ultimately de-pends on an excellent concentration of Ribonucleic acid (RNA) yield by appropriate technique. Our study aims consolidate cell collection method, preparation ex-traction techniques ensure a good for better analysis. From the results obtained, optimal strategy found involved mechanical denudation without enzy-matic process,...
Through a combination of in vitro structure–activity assays, crystallography, and vivo knockout experiments, we have identified structurally characterized the first bacterial borosin natural product.
Abstract Background Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the expression of BCR-ABL1 fusion gene. Tyrosine kinase inhibitors (TKI) are used to treat CML, but mutations in tyrosine domain contribute CML chemo-resistance. Therefore, finding alternative molecular-targeted therapy important for comprehensive treatment CML. MicroRNAs (miRNA) small non-coding regulatory RNAs which suppress their target genes binding 3′ untranslated region (3′UTR) mRNA....
Background: The anti-apoptotic protein Bcl-xL is a viable target for cancer therapy due to its critical role in formation and resistance chemotherapy. Insights into Bcl-xL’s have spurred the development of new category drugs called inhibitors, which mimic BH3-only cause apoptosis. It could be initiated using alkaloids, owing their remarkable biological characteristics. Alkaloids, among biggest obtainable from plants, possess distinctive structure characterized by presence nitrogen atom...