A5013267515- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Vascular anomalies and interventions
- Cardiovascular and Diving-Related Complications
- Cancer Cells and Metastasis
- Venous Thromboembolism Diagnosis and Management
- Congenital Diaphragmatic Hernia Studies
- Congenital heart defects research
- Medical and Biological Sciences
- Hip and Femur Fractures
- Cardiomyopathy and Myosin Studies
- Protease and Inhibitor Mechanisms
- Sarcoma Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Chronic Kidney Disease and Diabetes
- Atomic and Subatomic Physics Research
- Cardiac Valve Diseases and Treatments
- Neurogenetic and Muscular Disorders Research
- RNA modifications and cancer
- Dermatologic Treatments and Research
- Viral-associated cancers and disorders
- Urinary and Genital Oncology Studies
- Graphene and Nanomaterials Applications
- Cancer Research and Treatments
- Cardiac Structural Anomalies and Repair
Federal Almazov North-West Medical Research Centre
2017-2023
City Children's Hospital No. 22
2021-2023
Ministry of Health of the Russian Federation
2023
Federal State Budgetary Institution "Federal Center For Cardiovascular Surgery" Ministry of Health of The Russian Federation
2021
Moscow State University of Medicine and Dentistry
2017
Eli Lilly (United States)
2012
Memorial Sloan Kettering Cancer Center
2010
Kettering University
2009-2010
Matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases that catalyze the degradation reactions extracellular matrix components. In humans, 23 enzymes this known, which subdivided into 6 groups based on their structure and substrate types: collagenases, gelatinases, stromelysins, matrilizines, MMP membrane type other MMPs. functions diverse, an imbalance activity may be one etiological factors various diseases. The review considers classification, regulation genetic...
Abstract Purpose: Recent evidence suggests that at least some sarcomas arise through aberrant differentiation of mesenchymal stromal cells (MSCs), but MSCs have never been isolated directly from human sarcoma specimens. Experimental Design: We examined cell lines and primary adherent cultures derived surgical samples for features MSCs. further characterized as either benign or malignant by the presence tumor-defining genetic lesions tumor formation in immunocompromised mice. Results: show a...
Матриксные металлопротеиназы (ММП) - ферменты класса гидролаз, осуществляющие ферментативный катализ с помощью связанного в активном центре иона цинка. Функции ММП разнообразны, и нарушение баланса их активности может быть одним из этиологических факторов различных заболеваний. В данном обзоре рассмотрена классификация человека, особенности структуры регуляции, а также роль физиологических патологических процессах организме человека. Приведен перечень наиболее изученных на настоящий момент...
5012 Background: VEGF receptor-mediated-signaling contributes to ovarian cancer pathogenesis. Elevated expression and serum levels are associated with poor clinical outcomes. We investigated RAM, a fully human VEGFR-2 antagonist antibody, in patients (pts) persistent or recurrent EOC/FTC/PPC. Methods: Adult women EOC/FTC/PPC who had completed ≥1 platinum (P)-based chemotherapeutic (ct) regimen P-free interval (PFI) of <12 months (m), progression on, disease after P-based therapy were...
Introduction . TAPVC is a condition that requires diagnosis and surgical treatment in short period of time. As the result an absence direct connection between pulmonary veins left atrium, systemic venous return drainage to right heart with volume pressure overload. At same time, preload depending on atrial septal defect. The hemodynamic features create conditions for abnormal spread electric impulses, whereas necessity reconstruction level — reasons rhythm conduction disturbance...
Clinical data of a 39-year-old patient with corrected transposition the great arteries, combined complete atrioventricular block and conduction along an accessory pathway, are presented. The features changes in structure system, rhythm characteristic this rare congenital heart disease discussed.
ЖУРНАЛ ИМЕНИ АКАДЕМИКА Б
Abstract Introduction: Mesothelioma is an aggressive malignancy which spreads via local invasion. We have observed fine, long, non-adherent cable-like structures connecting mesothelioma cells in vitro are consistent with tunneling nanotubes, entity recently described malignant as well neuronal and immune cells. hypothesized that nanotubes facilitate intercellular communication between distant neighboring transfer of intracellular components. Materials Methods: Biphasic sarcomatoid cells,...
The clinical experience of performing ventriculoatrial shunting in children with hydrocephalus tumor etiology the Department Neurosurgery Children Almazov National Medical Research Centre is presented. Intraoperative and postoperative echocardiographic monitoring suggested as main method distal (atrial) catheter system.
Aim. Description of three clinical cases pediatric patients with dilated cardiomyopathy (DCMP) and an analysis their genetic causes. Material methods . Using the method targeted sequencing, data were obtained on presence pathogenic variants RBM20 gene in DCMP. Results. Three childhood DCMP development, associated structural disorders gene, are particularly described. It is known that involved splicing mRNA TTN encoding titin protein. A disorder can lead to a change biomechanical signaling...
<h3>ЦЕЛЬ ИССЛЕДОВАНИЯ</h3> Представить результаты анатомической коррекции транспозиции магистральных артерий (ТМА) за период с 1992 по 2021 г. <h3>МАТЕРИАЛ И МЕТОДЫ</h3> Исследование включало 504 ребенка ТМА, из них у 120 (23,8%) больных порок был ассоциирован дефектом межжелудочковой перегородки (ДМЖП), 60 (11,9%) пациентов сочетался ДМЖП и обструкцией дуги аорты. Всем детям была выполнена одномоментная коррекция ТМА методом артериального переключения, а также сопутствующих внутрисердечных...
O bjective. Pulmonary hypertension is one of the typical complications congenital heart defects with pulmonary overload circulation. Hemodynamic status circulation critically important for patients univentricular anatomy and determines opportunities results surgical treatment. Case report. We present a case report superior vena cava syndrome feigning thrombosis anastomosis in patient after Glenn procedure. Clear clinical picture, hemodynamic instability inability to exclude dysfunction were...
Pulmonary atresia with defect of interventricular septum and collateral pulmonary blood flow refers to complicated congenital malformation the heart. Surgical treatment represents itself as very difficult task because anatomical variability this abnormality. The main problem surgery is a definitive repair including correction maldistributions arterial bed (unifocalization flow), reconstruction outflow tract right ventricle closing defect. performance could be successful in patients case...
Some cancers carry massive genomic rearrangements, confined to one chromosomal region, that are thought arise in a single event.
Морозов А
The article presents a rare case of combination Ebstein’s anomaly and primary cardiomyopathy in 14-year-old teenager. clinical demonstrates diagnostic difficulties due to an unusual picture, as well interpretation choice treatment tactics.
Neonatal lupus is a rare disease associated with the circulation in mother’s blood of one or more autoantibodies to soluble intracellular ribonucleoproteins Ro/SS-A and La/SS-B. This extremely often manifested by congenital heart block, which can progress even after birth child. We have described case fibrosis, calcification cartilaginous metaplasia atrioventricular node zone, caused complete block child who died from neonatal lupus.
Whole-genome sequencing will soon become easily available, but many challenges lie ahead.
Abstract Background: Mesenchymal Stem Cells (MSCs) have been proposed as the cell of origin sarcoma. In soft tissues, microvascular pericyte has recently shown to MSC properties (Crisan et al, Cell 3:301). We previously reported isolation benign mesenchymal cultures from sarcoma surgical samples. These cells immunophenotype (CD45-CD31- CD73+CD105+CD90+) and in vitro differentiation potential characteristic MSCs. hypothesized that these sarcoma-associated MSCs (SA-MSCs) are derived pericytes...
Collagen-secreting cells in kidney fibrosis may be derived from microvascular pericytes the stroma rather than through an epithelial-to-mesenchymal transition.