A5004392590- Stroke Rehabilitation and Recovery
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Heat shock proteins research
- Cerebral Palsy and Movement Disorders
- Microfluidic and Bio-sensing Technologies
- Advanced biosensing and bioanalysis techniques
- Disaster Response and Management
- Protein Structure and Dynamics
- Microfluidic and Capillary Electrophoresis Applications
- Traumatic Brain Injury Research
- Art Therapy and Mental Health
- Acute Ischemic Stroke Management
- Burn Injury Management and Outcomes
- Physical Education and Training Studies
- RNA Research and Splicing
- Neurological Disorders and Treatments
- Cardiovascular and exercise physiology
University of Chicago
2022-2024
University of Missouri
2022
New York University
2022
ABSTRACT Ribosome biogenesis is among the most resource-intensive cellular processes, with ribosomal proteins accounting for up to half of all newly synthesized in eukaryotic cells. During stress, cells shut down ribosome part by halting rRNA synthesis, potentially leading massive accumulation aggregation-prone “orphan” (oRPs). Here we show that during heat shock yeast and human cells, oRPs accumulate as reversible condensates at nucleolar periphery recognized Hsp70 co-chaperone Sis1/DnaJB6....