A5029886933- Advanced Drug Delivery Systems
- Pharmacogenetics and Drug Metabolism
- Drug Solubulity and Delivery Systems
- Andrographolide Research and Applications
- Ginseng Biological Effects and Applications
- Inflammatory mediators and NSAID effects
- Meat and Animal Product Quality
- Phytochemicals and Medicinal Plants
- Aquaculture disease management and microbiota
- Gastroesophageal reflux and treatments
- Phytochemistry and Bioactive Compounds
- Receptor Mechanisms and Signaling
- Drug-Induced Hepatotoxicity and Protection
- Proteins in Food Systems
- Antimicrobial Peptides and Activities
- Pharmacological Effects and Toxicity Studies
- Biochemical Analysis and Sensing Techniques
- Ion channel regulation and function
- Pharmacological Effects of Natural Compounds
- Cardiac electrophysiology and arrhythmias
- Bacterial biofilms and quorum sensing
- Advancements in Transdermal Drug Delivery
- Seaweed-derived Bioactive Compounds
- Complementary and Alternative Medicine Studies
- Oral microbiology and periodontitis research
Jadavpur University
2009-2020
TCG Lifesciences (India)
2015-2016
Breast cancer is considered as an increasing major life-threatening concern among the malignancies encountered globally in females. Traditional therapy far from satisfactory due to drug resistance and various side effects, thus a search for complementary/alternative medicines natural sources with lesser effects being emphasized. Andrographis paniculata, oriental, traditional medicinal herb commonly available Asian countries, has long history of treating variety diseases, such respiratory...
Context: Andrographis paniculata (Burm.f.) Nees (Acanthaceae) is widely used in tribal medicine India and some other countries for multiple clinical applications. It contains andrographolide (AG) (diterpenoid lactone), a major phytomarker which probably accounts its medicinal properties.Objective: This study investigates the site-specific distribution of AG different tissues rats pharmacokinetic parameter evaluation by using validated liquid chromatography tandem mass spectrometry (LC-MS/MS)...
Abstract Objectives This study attempts to investigate the antimicrobial properties of Kalanchoe blossfeldiana with a particular reference quorum sensing (QS)-mediated biofilm formation. Methods The methanol extract K. leaves (MEKB) was evaluated for including QS-controlled production (including virulence factor, motility and lactone formation) in Pseudomonas aeruginosa. Methanol also anti-cytokine (tumour necrosis factor-alpha, interleukin-6 interleukin-1 beta) peripheral blood mononuclear...
The purpose of the present study was to develop buoyant beads for intragastric delivery furosemide in order evaluate effect incorporated sunflower oil on physiochemical properties alginate beads. Sunflower entrapped were prepared by emulsion-gelation technique. During preparation various batches beads, ratio water (v/v), drug polymer (w/w), kept as variables at two levels; either high or low. Smooth, spherical with nominal weight variation obtained. All floated 24 hours a lag time 5–10 min....
<b>Objective:</b> <i>Bruguiera gymnorrhiza</i> (BRG) (L.) Lamk (<i>Rhizophoraceae</i>), a mangrove species, is widely distributed in the Pacific region, eastern Africa, Indian subcontinent, and subtropical Australia. The leaves of this plant are traditionally used for treating burns inflammatory lesions. This study isolates bioactive compound from methanol extract BRG evaluates possible mechanisms anti-inflammatory activity involved.<br><b>Materials Methods:</b> Bioassay-guided fractionation...
The present study was undertaken to investigate the food-drug interaction of carbamazepine (CBZ). Common fruit juices [grapefruit juice (GFJ), lime (LJ)], known inhibit enzyme cytochrome P450 3A4 (CYP3A4), and some widely consumed beverages [milk (M), black tea (BT)] were involved in this presence CBZ, as might happen during clinical therapy. effects on pharmacokinetics drug-induced toxicity CBZ observed after concomitant administration for a period 28 days. Accordingly, influence altered...
<i>Gymnema sylvestre</i> is traditionally used for diabetes mellitus. A literature survey revealed very few reports, particularly on rat liver microsomal stability, caco-2 permeability and efflux concerns its correlation with the bioavailability of gymnemagenin, an important component <i>G. sylvestre</i>. Therefore, objective our study was to investigate <i>in vitro</i> stability along gymnemagenin establish a probable these findings pharmacokinetic parameters after oral intravenous...
Drugs with low arrhythmogenic tendencies fail to overcome the threshold prolong QT interval and are ruled as safe.However, at provoked conditions these drugs might have possibility precipitate arrhythmia.Although small yet prolongation capability of such must be investigated.The required was attenuated using chronic dose furosemide clarithromycin.Once attenuated, ranitidine explored.Furosemide 10mg.kg - IP on co-administration Clarithromycin 70mg.kg orally for seven day manifested QTc par...