A5041036883- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- Sphingolipid Metabolism and Signaling
- Lipid Membrane Structure and Behavior
- Antibiotic Resistance in Bacteria
- Cystic Fibrosis Research Advances
- Microbial Metabolic Engineering and Bioproduction
- Bacterial Genetics and Biotechnology
- Amino Acid Enzymes and Metabolism
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Plant Disease Resistance and Genetics
- Inhalation and Respiratory Drug Delivery
- Enzyme Structure and Function
- Viral gastroenteritis research and epidemiology
- Plant-Microbe Interactions and Immunity
- Microbial Natural Products and Biosynthesis
- Neonatal Respiratory Health Research
- Plant Pathogens and Resistance
- Infections and bacterial resistance
University of Vermont
2017-2025
Rutgers, The State University of New Jersey
2022-2025
Rütgers (Germany)
2024
Rutgers Sexual and Reproductive Health and Rights
2024
Lafayette College
2017
Sphingoid bases, including sphingosine, are important components of the antimicrobial barrier at epithelial surfaces where they can cause growth inhibition and killing susceptible bacteria. Pseudomonas aeruginosa is a common opportunistic pathogen that less to sphingosine than many Gram-negative Here, we determined deletion sphBCD operon reduced in presence sphingosine. Using mutants, complementation assays P. PAO1, sphC sphB genes, encoding periplasmic oxidase cytochrome c, respectively,...
Hemolytic phospholipase C, PlcH, is an important virulence factor for
ABSTRACT Clostridium difficile is a Gram-positive spore-forming obligate anaerobe that leading cause of antibiotic-associated diarrhea worldwide. In order for C. to initiate infection, its aerotolerant spore form must germinate in the gut mammalian hosts. While almost all organisms use transmembrane germinant receptors trigger germination, uses pseudoprotease CspC sense bile salt germinants. activates related subtilisin-like protease CspB, which then proteolytically cortex hydrolase SleC....
Abstract Sphingolipids are critical to eukaryotic cell membrane structure and function play important roles in a variety of host processes that impact infection. Thus, it is not surprising many pathogens can perturb sphingolipid homeostasis, often promote pathogenesis. Pseudomonas aeruginosa common opportunistic pathogen that, among virulence factors, secretes the dual-functioning hemolytic phospholipase C/sphingomyelinase, PlcH. PlcH contributes P. pathogenesis several ways plcH mutants...
Stenotrophomonas maltophilia is an important infecting bacterium in the airways of people with cystic fibrosis (CF). However, compared to other CF pathogens, S. has been relatively understudied. The significance our research provide insight into global transcriptomic changes response a medium that was designed mimic aspects lung. This study elucidates overall metabolic occur when encounters lung and generates road map candidate genes test using vitro vivo models CF.
Sphingoid bases, including sphingosine, are important components of the antimicrobial barrier at epithelial surfaces where they can cause growth inhibition and killing susceptible bacteria.
Glutamine amidotransferase-1 domain-containing AraC-family transcriptional regulators (GATRs) are present in the genomes of many bacteria, including all Pseudomonas species. The involvement several characterized GATRs amine-containing compound metabolism has been determined, but full scope GATR ligands and regulatory networks still unknown. Here, we characterize putida ’s detection animal-derived amine creatine, a particularly enriched muscle ciliated cells by creatine-specific GATR,...
Abstract The hemolytic phospholipase C, PlcH, is an important virulence factor for Pseudomonas aeruginosa . PlcH preferentially hydrolyzes sphingomyelin and phosphatidylcholine this hydrolysis activity can drives tissue damage, inflammation, interferes with the oxidative burst of immune cells. Among other contributors, transcription plcH was previously shown to be induced by phosphate starvation via PhoB choline metabolite, glycine betaine, GbdR. Here, we show that sphingosine induce...
ABSTRACT Glutamine amidotransferase-1 domain-containing AraC-family transcriptional regulators (GATRs) are present in the genomes of many bacteria, including all Pseudomonas species. The involvement several characterized GATRs amine-containing compound metabolism has been determined, but full scope GATR ligands and regulatory networks still unknown. Here, we characterize putida’ s detection animal-derived amine compound, creatine, a particularly enriched muscle ciliated cells by...