A5023348784- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
- Orthopaedic implants and arthroplasty
- Reconstructive Surgery and Microvascular Techniques
- Tissue Engineering and Regenerative Medicine
- Connective tissue disorders research
- Temporomandibular Joint Disorders
- Magnesium Alloys: Properties and Applications
- Legal processes and jurisprudence
- Proteoglycans and glycosaminoglycans research
- Electrospun Nanofibers in Biomedical Applications
- Dental materials and restorations
- Facial Trauma and Fracture Management
- Voice and Speech Disorders
- Facial Nerve Paralysis Treatment and Research
- Surgical Sutures and Adhesives
- Orthodontics and Dentofacial Orthopedics
Charité - Universitätsmedizin Berlin
2024
University Medical Center Hamburg-Eppendorf
2018-2020
Universität Hamburg
2018-2020
Eppendorf (Germany)
2019
Republic Klaipeda Hospital
2017
Goethe University Frankfurt
2012-2013
University Hospital Frankfurt
2013
The use of non-resorbable polytetrafluoroethylene (PTFE) membranes is indicated for the treatment large, non-self-containing bone defects, or multi-walled defects in case vertical augmentations. However, less known about molecular basis foreign body response to PTFE membranes. In present study, inflammatory tissue responses a novel high-density (dPTFE) barrier membrane have preclinically been evaluated using subcutaneous implantation model BALB/c mice by means histopathological and...
This study compared the material-specific tissue response to synthetic, hydroxyapatite-based bone substitute material NanoBone (NB) with that of xenogeneic, bovine-based Bio-Oss (BO). The sinus cavities 14 human patients were augmented NB and BO in a split-mouth design. Six months after augmentation, biopsies extracted for histological histomorphometric investigation prior dental implant insertion. following evaluated: cellular inflammatory pattern, induction multinucleated giant cells,...
ABSTRACT Purpose: In this study the de novo bone formation capacity of a nanocrystalline hydroxyapatite substitute was assessed 3 and 6 months after its insertion into human sinus cavity. Materials Methods: Sinus cavity augmentation performed in total 14 patients ( n = 7 implantation months; months) with severely atrophic maxillary bone. The specimens obtained were analyzed histologically histomorphometrically special focus on metabolism within residual augmented region. Results: This...
Biphasic bone substitutes (BBS) are currently well-established biomaterials. Through their constant development, even natural components like hyaluronic acid (HY) have been added to improve both handling and also regenerative properties. However, little knowledge exists regarding the consequences of addition HY biocompatibility inflammatory tissue reactions. Thus, present study was conducted, aiming analyze influence two different amounts high molecular weight (HMWHY), combined with a BBS,...
The physicochemical properties of synthetically produced bone substitute materials (BSM) have a major impact on biocompatibility. This affects bony tissue integration, osteoconduction, as well the degradation pattern and correlated inflammatory responses including macrophages multinucleated giant cells (MNGCs). Thus, influencing factors such size, special surface morphologies, porosity, interconnectivity been subject extensive research. In present publication, influence granule size three...
The present study investigates the in vivo tissue reaction and integration behavior of an injectable bone substitute material (IBS) composed a water-based gel combined with nano hydroxyapatite particles biphasic calcium phosphate granules. results IBS were compared to granules (BBSM) same chemical composition.The subcutaneous implantation model 40 female 5-week-old CD-1 mice up 60 days after was used for conduction experiments. Moreover, established histological, histopathological...
Short implants present a promising approach for patients with advanced atrophy to avoid augmentative procedures. However, concerns about increased biological and technical complications due an unfavorable implant-crown ratio are still present.The aim of the retrospective study was evaluate whether reduced implant length has any impact on success peri-implant hard soft tissue health in placed posterior maxilla sinus augmentation procedures.Fourteen received total 30 7-mm maxilla. Implants...
Background/Aim: A new manufacturing process has been established for the condensation of collagen derived from porcine pericardium to develop a dental barrier membrane (CPM) that can provide long functionality. native (PM) was used as control. Materials and Methods: Established in vitro procedures using L929 MC3T3 cells were cytocompatibility analyses. For vivo study, subcutaneous implantation both types 40 BALB/c mice histological, immuno histochemical histomorphometrical methods conducted....
The present prospective randomized split-mouth trial reports on the 3-year clinical and radiological follow-up investigation of implants placed 7 months after sinus augmentation with 2 different bone substitute materials. aim study was to complete histologic observation cellular reactions by analyses volumetric changes augmented A performed in 14 patients synthetic material Nanobone (NB) xenogeneic Bio-Oss (BO). Changes volume density biomaterials were investigated analysis computed...
GBR (guided bone regeneration) is a standard procedure for building up bony defects in the jaw. In this procedure, resorbable membranes made of bovine and porcine collagen are increasingly being used, which, addition to many possible advantages, could have potential disadvantage shorter barrier functionality, especially when augmenting large-volume defects. Thus, it importance evaluate integration behavior standing time using specialized methods predict its respective biocompatibility. This...
The present publication reports the purification effort of two natural bone blocks, that is, an allogeneic block (maxgraft®, botiss biomaterials GmbH, Zossen, Germany) and a xenogeneic (SMARTBONE®, IBI S.A., Mezzovico-Vira, Switzerland) in addition to previously published results based on histology. Furthermore, specialized scanning electron microscopy (SEM) vitro analyses (XTT, BrdU, LDH) for testing cytocompatibility ISO 10993-5/-12 have been conducted. microscopic showed both blocks...
Background: Due to bone loss, implant placement in the posterior mandible is often impossible without prior augentative procedures. The reconstruction of defects with horizontal and vertical components using particulated grafts requires a mechanically stable structure for stabilization grafting material. Although titanium‐reinforced membranes titanium meshes have been shown be effective this indication, necessity their removal, separate surgical procedure, seen as disadvantage. Since...
Background: This study evaluated the efficacy of recombinant human bone morphogenetic protein-2 (rhBMP-2) in inducing de novo formation during augmentation severely resorbed posterior maxilla for dental implant placement. Methods: Composite grafts consisting rhBMP-2/absorbable collagen sponge (ACS) mixed with deproteinized bovine mineral (DBBM) Bio-Oss a 1:1 ratio were used to reconstruct maxillae 13 patients (five men, eight women; age range: 50 66 years). Three treated sinus floor alone,...