A5071404564- Eating Disorders and Behaviors
- Obesity, Physical Activity, Diet
- Genetic Associations and Epidemiology
- Obsessive-Compulsive Spectrum Disorders
- Child Nutrition and Feeding Issues
- Impact of Technology on Adolescents
- Behavioral Health and Interventions
- Substance Abuse Treatment and Outcomes
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Consumer Behavior in Brand Consumption and Identification
- Obesity and Health Practices
- Nutrition, Genetics, and Disease
- Prenatal Substance Exposure Effects
- Cardiovascular Disease and Adiposity
- Child and Adolescent Psychosocial and Emotional Development
- Genomic variations and chromosomal abnormalities
- Early Childhood Education and Development
- Digestive system and related health
- Mental Health Research Topics
- LGBTQ Health, Identity, and Policy
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Suicide and Self-Harm Studies
- Attention Deficit Hyperactivity Disorder
- Genetic Syndromes and Imprinting
Texas Tech University
2024-2025
University of North Carolina at Chapel Hill
2015-2024
UNSW Sydney
2021
Neuroscience Research Australia
2021
Genomics (United Kingdom)
2017
John Wiley & Sons (United Kingdom)
2016
Washington University in St. Louis
2005-2015
University of Colorado Boulder
2010-2012
Michigan State University
2003-2005
ABSTRACT Objective Self‐report measures of ARFID symptoms (e.g., Nine‐Item Avoidant/Restrictive Food Intake Disorder Screen [NIAS]) are used to assess symptom differences between groups. Measurement invariance techniques clarify if groups interpret a measure similarly, providing foundation for examining group differences. Considering age and reporter status parent vs. self‐report), we investigated measurement the NIAS in (1) self‐reporting adults adolescents; (2) reports on children (3)...
The extent to which genetic and environmental factors influenced anorexia nervosa ( AN ), major depressive disorder MDD suicide attempts SA ) were evaluated. Participants 6,899 women from the Swedish Twin Study of Adults: Genes Environment. A Cholesky decomposition assessed independent overlapping contributions , . Genetic accounted for a substantial amount liability all three traits; unique most remaining liability. Shared may underlie coexpression these traits. Results underscore...
Abstract Eating disorders and substance use frequently co‐occur. Twin studies reveal shared genetic variance between liabilities to eating use, with the strongest associations symptoms of bulimia nervosa problem alcohol (genetic correlation [ r g ], twin‐based = 0.23‐0.53). We estimated disorder phenotypes using data from genome‐wide association (GWAS). Four (anorexia [AN], AN binge eating, without a factor score), eight substance‐use‐related (drinks per week, [AUD], smoking initiation,...
There is a high rate of co-morbidity between binge-eating and binge-drinking behaviors, suggesting common neuropathology. Recently, phosphodiesterase 4B (PDE4B) was identified as pleiotropic gene associated with comorbid alcohol use disorder (AUD) anorexia nervosa in genome-wide association study, implicating PDE4B potential contributor to shared genetic risk these disorders. To address this possibility, we developed novel mouse model co-morbid -drinking C57BL/6NJ mice which underwent 10...
Objective: Rates of alcohol dependence are elevated in women with eating disorders who engage binge or compensatory behaviors compared do not report and healthy controls. Alcohol dependence, eating, heritable; however, it is unclear whether a shared genetic liability contributes to the phenotypic association among these traits, little information exists regarding this men. We investigated environmental correlations male female twins. Method: Participants included 5,993 same- opposite-sex...
Abstract Objective Cardiovascular complications occur in up to 80% of patients with anorexia nervosa (AN), yet the underlying mechanisms warrant further investigation. We assessed genetic correlation ( r g ) between AN and cardiovascular disease (CVD) events inform whether elevated risk among individuals is due shared effects. Method used genome‐wide association study summary statistics for N = 72,517), binge eating 12,630), without 12,516), six CVD 390,142 977,323). calculated s via linkage...
This study examined the genetic and environmental influences on rumination its associations with several forms of psychopathology in a sample adult twins (
ABSTRACT Objective Although prior studies have demonstrated that depression is associated with an overeating–binge eating dimension (OE‐BE) phenotypically, little research has investigated whether familial factors contribute to the co‐occurrence of these phenotypes, especially in community samples multiple racial/ethnic groups. We examined extent which (i.e., genetic and shared environmental) influences overlapped between Major Depressive Disorder (MDD) OE‐BE a population‐based sample were...
ABSTRACT Objective Purging disorder (PD) was recently included as an otherwise specified feeding or eating (OSFED) in the DSM‐5; however, limited information is available on its prevalence, and etiology unknown. Method Data from 1,790 monozygotic 1,440 dizygotic European American female twins (age range = 18–29 years) Missouri Adolescent Female Twin Study were used to investigate prevalence familial influences for PD. A structured clinical interview assessed lifetime DSM‐IV criteria...
Objective: Research indicates that low parental monitoring increases the risk for early substance use. Because tends to co-occur with other familial and neighborhood factors, specificity of association is challenging establish. Using logistic regression propensity score analyses, we examined associations between use in European American (EA) African (AA) girls, controlling factors associated monitoring. Method: Participants were 3,133 EA 523 AA girls from Missouri Adolescent Female Twin...
Cyclic AMP (cAMP)-dependent signaling is highly implicated in the pathophysiology of alcohol use disorder (AUD), with evidence supporting efficacy inhibiting cAMP hydrolyzing enzyme phosphodiesterase 4 (PDE4) as a therapeutic strategy for drinking reduction. Off-target emetic effects associated non-selective PDE4 inhibitors has prompted development selective isozyme treating neuropsychiatric conditions. Herein, we examined effect PDE4B inhibitor A33 (0–1.0 mg/kg) on both female and male mice...
It is unknown whether there are racial differences in the heritability of major depressive disorder (MDD) because most psychiatric genetic studies have been conducted samples comprised largely white non-Hispanics. To examine potential between African-American (AA) and European-American (EA) young adult women (1) Diagnostic Statistical Manual Mental Disorders, 4th Edition (DSM-IV) MDD prevalence, symptomatology, risk factors, (2) and/or environmental liability to MDD, we analyzed data from a...
Aspects of disordered eating and personality traits, such as neuroticism, are correlated individually heritable. We examined the phenotypic correlation between binge episodes indices (neuroticism, extraversion, openness to experience, agreeableness, conscientiousness, control/impulsivity). For correlations ≥|0.20|, we estimated extent which genetic environmental factors contributed this correlation. Participants included 3,446 European American same-sex female twins from Missouri Adolescent...