Despite treatment advances for sepsis and pneumonia, significant improvements in outcome have not been realized. Antiplatelet therapy may improve pneumonia sepsis. In this study, the authors show that ticagrelor reduced leukocytes with attached platelets as well inflammatory biomarker interleukin (IL)-6. Pneumonia patients receiving required less supplemental oxygen lung function tests trended toward improvement. Disruption of P2Y12 receptor a murine model protected against response,...

<sec> <title>BACKGROUND</title> Different factors, such as parental trauma or parenting style, may influence their child(ren)’s medical treatment adherence. Authoritative, “flexible” is known to develop the most nurturing relationship between parent and child(ren). </sec> <title>OBJECTIVE</title> This study examines trauma, adherence recommendations. <title>METHODS</title> Participants were recruited through Amazon.com’s Mechanical Turk (mTurk), an online crowdsourcing platform. 18 years...

Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) is an organophosphate flame retardant. The primary TDCPP metabolite, bis(1,3-dichloro-2-propyl) (BDCPP), detectable in the urine of over 90 % Americans. Epidemiological studies show sex-specific associations between urinary BDCPP levels and metabolic syndrome, which established risk factor for type 2 diabetes, heart disease, stroke. We used a mouse model to determine whether exposure disrupts glucose homeostasis. Six-week old male female C57BL/6J...

Abstract Background Insomnia is a well‐established, prospective risk factor for Alcohol Use Disorder. Thus, targeting sleep problems could serve as novel and efficacious means of reducing problematic drinking. Here, we examined the potential utility well‐validated, interactive, easy to use, self‐paced digital cognitive behavioral therapy insomnia program. In randomized, single‐blind pilot study, impact treatment with Sleep Healthy Using Internet (SHUTi) on drinking outcomes in sample heavy...

While progress has been made in identifying common genetic variants associated with human diseases, for most of complex the identified only account a small proportion heritability. Challenges remain finding additional unknown predisposing to diseases. With advance next-generation sequencing technologies, studies have become commonplace research. The ongoing exome-sequencing and whole-genome-sequencing generate massive amount allow researchers comprehensively investigate their role discovery...

Abstract Many genetic markers have been associated with variations in treatment response to analgesics, but none assessed the context of combination therapies. In this study, effects nortriptyline and morphine were tested for an association relevant pain pathways. Treatment determined single A total 24 functional nucleotide polymorphisms within gene loci mu-opioid receptor ( OPRM1 ) locus, ATP-Binding Cassette B1 Transporter ABCB1 ), Cytochrome P450 family CYP2C19 CYP2D6 catecholamine...

Existing literature supports benefits of early tracheostomy and percutaneous endoscopic gastrostomy (PEG) in certain patient populations. The aim this study was to review PEG placement data patients with hemorrhagic stroke order identify factors associated earlier evaluate outcomes.

Motivated by a practical need for the comparison of hemolysis curves at various treatment levels, we propose novel method pairwise mean functional responses. The - percent as function time mice erythrocytes (red blood cells) hydrochloric acid have been measured among different levels. This data set fits well within analysis paradigm, in which series is considered realization underlying stochastic process or smooth curve. Previous research has only provided methods identifying some...

Historically, the majority of statistical association methods have been designed assuming availability SNP-level information. However, modern genetic and sequencing data present new challenges to access sharing genotype-phenotype datasets, including cost management, difficulties in consolidation records across research groups, etc. These issues make based on summary statistics particularly appealing. The most common form combining is a sum squared scores, possibly weighted, as burden tests...

Recent technological advances equipped researchers with capabilities that go beyond traditional genotyping of loci known to be polymorphic in a general population. Genetic sequences study participants can now assessed directly. This capability removed technology-driven bias toward scoring predominantly common polymorphisms and let reveal wealth rare sample-specific variants. Although the relative contributions trait variation are being debated, faced need for new statistical tools...

ABSTRACT Objective This study determined whether hypercholesterolemia would contribute to both the initiation and progression of angiotensin (Ang)II-induced abdominal aortic aneurysms (AAAs) in mice. Methods Results To determine accelerates AAAs, male low-density lipoprotein (LDL) receptor -/- mice were either fed one week Western diet prior starting AngII infusion or initiated after infusion. During first infusion, normal had less luminal expansion suprarenal aorta compared those The two...

We approach the problem of combining top-ranking association statistics or P-values from a new perspective which leads to remarkably simple and powerful method. Statistical methods, such as Rank Truncated Product (RTP), have been developed for associations this general strategy proved be useful in applications detecting combined effects multiple disease components. To increase power, these methods aggregate signals across top ranking SNPs, while adjusting their total number assessed study....

With advancements in next-generation sequencing technology, a massive amount of data is generated, which offers great opportunity to comprehensively investigate the role rare variants genetic etiology complex diseases. Nevertheless, high-dimensional poses challenge for statistical analysis. The association analyses based on traditional methods suffer substantial power loss because low frequency and extremely high dimensionality data. We developed Weighted U Sequencing test, referred as...

Abstract Background Since October 2014, the Centers for Medicare and Medicaid Services has penalized 25% of U.S. hospitals with highest rates hospital-acquired conditions under Hospital Acquired Conditions Reduction Program (HACRP). While early evaluations HACRP program reported cumulative reductions in conditions, more recent studies have not found a clear association between receipt penalty hospital quality care. We posit that some this disconnect may be driven by frequent scoring updates....

The authors quantified the impact of use telehealth services on patient-level clinical outcomes among children with complex behavioral and emotional needs in Idaho during COVID-19 pandemic by comparing data collected 2020 for same months 2019.Longitudinal statewide Child Adolescent Needs Strengths (CANS) assessments were extracted from Idaho's mental health system. Prepandemic matched to midpandemic assessments. A linear mixed-effect model was used explore four child-level outcomes:...

Measured as elapsed time from first use to dependence syndrome onset, the estimated "induction interval" for cocaine is thought be short relative cannabis interval, but little known about risk of becoming dependent during months after onset use. Virtually all published estimates this facet drug epidemiology are life histories elicited years To improve estimation, we turn new month-wise data nationally representative samples newly incident users identified via probability sampling and...

Behavioral economic demand provides a multidimensional understanding of reinforcement. Commodity purchase tasks are an efficient method for measuring in human participants. One challenge translating these procedures to electronic nicotine delivery systems (ENDS or e-cigarettes) is defining commodity units given the lack standardization e-cigarette marketplace.The purpose this study was directly compare methods operationalizinge-cigarette purchases, puffs, cartridges, and mLs liquid, using...