A5059528272- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac electrophysiology and arrhythmias
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Viral Infections and Immunology Research
- Healthcare cost, quality, practices
- Cardiomyopathy and Myosin Studies
- Pericarditis and Cardiac Tamponade
- Hemoglobinopathies and Related Disorders
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- COVID-19 and healthcare impacts
- Ion channel regulation and function
- MRI in cancer diagnosis
University of Kentucky
2016-2025
Brigham and Women's Hospital
2019-2024
University of Alabama at Birmingham
2024
Harvard University
2024
Alaska Heart and Vascular Institute
2022
Society for Cardiovascular Magnetic Resonance
2019-2021
Lexington VA Health Care System
2015-2020
Albert B. Chandler Hospital
2020
Temple College
2017
Texas A&M University
2017
Myocardial infarction (MI) documented by late gadolinium enhancement (LGE) has clinical and prognostic importance, but its detection is sometimes compromised poor contrast between blood MI. MultiContrast Delayed Enhancement (MCODE) a technique that helps discriminate subendocardial MI from pool simultaneously providing T2-weighted image with PSIR (phase sensitive inversion recovery) LGE image. In this validation study, our goal was to prospectively compare standard imaging MCODE in the of...
Stress cardiac magnetic resonance imaging (CMR) has demonstrated excellent diagnostic and prognostic value in single-center studies.This study sought to investigate the of stress CMR downstream costs from subsequent testing a retrospective multicenter United States.In this study, consecutive patients 13 centers across 11 states who presented with chest pain syndrome were referred for followed target period 4 years. The authors associated findings primary outcome cardiovascular death or...
BACKGROUND: The appropriate use criteria for revascularization of stable ischemic heart disease have not been evaluated using randomized data. Using data from the ISCHEMIA trial (International Study Comparative Health Effectiveness with Medical and Invasive Approaches; July 2012 to January 2018, 37 countries), health status benefits an invasive strategy over a conservative one were examined within scenarios. METHODS: Among 1833 participants mapped 36 scenarios, symptom was assessed Seattle...
Regadenoson, dipyridamole and adenosine are commonly used vasodilators in myocardial perfusion imaging for the detection of obstructive coronary artery disease. There few comparative studies vasodilator properties regadenoson, humans. The specific aim this study was to determine relative potency these three by quantifying stress rest humans using cardiovascular magnetic resonance (CMR). Fifteen healthy normal volunteers, with Framingham score less than 1% underwent testing regadenoson (400...
To compare the image quality of coronary CT angiography (CTA) studies between standard filtered back projection (FBP) and adaptive iterative dose reduction in three-dimensions (AIDR3D) reconstruction using noise additional software to simulate reduced radiation exposure. Images from 93 consecutive clinical CTA were processed utilizing FBP, FBP with 50 % simulated (FBP50 %), AIDR3D (AIDR50 %). Signal-to-noise ratio (SNR) contrast-to-noise (CNR) measured within 5 regions-of-interest, for each...
Women with chronic coronary disease are generally older than men and have more comorbidities but less atherosclerosis. We explored sex differences in revascularization, guideline-directed medical therapy, outcomes among patients ischemia on stress testing, without invasive management.
Poly(ADP-ribose) polymerase-1 (PARP-1; EC ) is an abundant nuclear enzyme, activated by DNA strand breaks to attach up 200 ADP-ribose groups proteins. As retroviral infection requires integrase-catalyzed breaks, we examined of pseudotyped HIV type I in fibroblasts from mice with a targeted deletion PARP-1. Viral almost totally abolished PARP-1 knockout fibroblasts. This protection reflects prevention viral integration into the host genome. These findings suggest potential for PARP inhibitors...
The most common defect in cystic fibrosis, deletion of phenylalanine from position 508 the fibrosis transmembrane conductance regulator (ΔF508 CFTR), decreases trafficking this protein to cell surface membrane. Previous studies have shown that low temperature and high concentrations glycerol or trimethylamine N-oxide can partially counteract processing ΔF508 CFTR. present study investigates whether physiologically relevant organic solutes, accumulated by cotransporter proteins, rescue...
Anaemia and RBC (red blood cell) transfusion may be associated with worse clinical outcomes, especially longer storage duration prior to transfusion. The mechanisms underlying these harmful effects are unknown. RBCs have been proposed buffer plasma S1P (sphingosine 1-phosphate), a lysophospholipid essential for the maintenance of endothelial integrity important in regulation haematopoietic cell trafficking. present study examined effect anaemia, on levels. Plasma from 30 individuals...
Abstract Contemporary approaches for developing interventions and assessing pre-clinical cardiovascular risk frequently utilize animal in vitro models. However, these models currently lack normal species-specific reference ranges similar to what exists humans. The genetically diverse Collaborative Cross (CC) population that human genetic heterogenetiety was characterized develop mouse-specific cardiac Mus muscuslus , the most commonly used pre-clincial model. Heart function analyzed males...
AimsKnowledge of adverse events associated with regadenoson perfusion cardiac magnetic resonance (CMR) and patient tolerability has implications for safety staff training. We sought to assess the stress CMR.
It remains controversial whether cardiovascular magnetic resonance imaging with gadolinium only enhances acutely infarcted or also salvaged myocardium. We hypothesized that enhancement of myocardium may be due to altered extracellular volume (ECV) and contrast kinetics compared normal If so, these mechanisms could contribute overestimation acute myocardial infarction (AMI) size.Imaging was performed at 1.5T ≤ 7 days after AMI serial T1 mapping volumetric early (5 min post-contrast) late (20...
The T1 Mapping and Extracellular volume (ECV) Standardization (T1MES) program explored mapping quality assurance using a purpose-developed phantom with Food Drug Administration (FDA) Conformité Européenne (CE) regulatory clearance. We report measurement repeatability across centers describing sequence, magnet, vendor performance. Phantoms batch-manufactured in August 2015 underwent 2 years of structural imaging, B0 B1, "reference" slow testing. Temperature dependency was evaluated by the...
The role of stress cardiac magnetic resonance (CMR) imaging in clinical decision-making by reclassification risk across American College Cardiology/American Heart Association guideline-recommended categories has not been established.To examine the utility CMR for patients without a history coronary artery disease (CAD) who presented with suspected myocardial ischemia.A retrospective, multicenter cohort study median follow-up 5.4 years (interquartile range, 4.6-6.9) was conducted at 13...