A5057018598- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Hormonal and reproductive studies
- Coronary Interventions and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Smoking Behavior and Cessation
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Nitric Oxide and Endothelin Effects
- Vitamin D Research Studies
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Disease and Adiposity
- Sepsis Diagnosis and Treatment
- Bone health and osteoporosis research
- Cardiac Arrhythmias and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood properties and coagulation
- Asthma and respiratory diseases
- Mast cells and histamine
- Cardiac electrophysiology and arrhythmias
- Pharmacology and Obesity Treatment
- Cardiovascular Health and Disease Prevention
- Receptor Mechanisms and Signaling
- Blood Pressure and Hypertension Studies
- Eicosanoids and Hypertension Pharmacology
- Pharmacological Effects and Assays
Veterans Health Administration
2015-2023
Kansas City VA Medical Center
2014-2022
University of Kansas Medical Center
2015-2022
University Hospital and Clinics
2007-2015
University Medical Center
2007-2015
University of California, San Francisco
2009-2013
University of Kansas
2013
San Joaquin Valley Agricultural Sciences Center
2009
California State University, Fresno
2007
Catholic Medical Center
2001-2004
AimsThere is a significant uncertainty regarding the effect of testosterone replacement therapy (TRT) on cardiovascular (CV) outcomes including myocardial infarction (MI) and stroke. The aim this study was to examine relationship between normalization total (TT) after TRT CV events as well all-cause mortality in patients without previous history MI
Background The mechanisms involved in the dysfunction of both endothelium-dependent vasodilatation (EDV) and NO biosynthesis related to smoking are unclear. In this study, EDV was assessed healthy smokers nonsmokers vivo and, using serum from same individuals, biosynthetic pathway vitro. Methods Results Flow-mediated brachial artery measured 23 male patients (8 15 smokers). Serum collected, added confluent (≈85%) monolayers human umbilical vein endothelial cells (HUVECs), incubated for 12...
Background— Our group has previously shown that human umbilical vein endothelial cells exposed to smokers’ serum decreased nitric oxide (NO) production and synthase (eNOS) activity in the presence of increased eNOS expression. In present study, we examined whether these observations extended coronary artery (HCAECs). addition, role reactive oxygen species observed alterations was examined. Methods Results— HCAECs were incubated with from 10 nonsmokers 15 smokers for 12 hours or without...
Abstract Objective The aim of the study was to examine effects vitamin D (Vit-D) treatment and nontreatment on Vit-D–deficient patients without a prior history myocardial infarction (MI). Materials Methods This retrospective, observational, nested case–control (N = 20 025) with low 25-hydroxyvitamin ([25-OH]D) levels (<20 ng/mL) who received care at Veterans Health Administration from 1999 2018. Patients were divided into 3 groups: Group A (untreated, ≤20 ng/mL), B (treated, 21-29 C...
BACKGROUND: The appropriate use criteria for revascularization of stable ischemic heart disease have not been evaluated using randomized data. Using data from the ISCHEMIA trial (International Study Comparative Health Effectiveness with Medical and Invasive Approaches; July 2012 to January 2018, 37 countries), health status benefits an invasive strategy over a conservative one were examined within scenarios. METHODS: Among 1833 participants mapped 36 scenarios, symptom was assessed Seattle...
The purpose of this study was to examine the effect cigarette smoke exposure (CSE) on clot dynamics and fibrin architecture isolate relative contribution platelets fibrinogen dynamics.From young healthy males smokers (n=34) nonsmokers a baseline blood drawn, had another draw after smoking 2 regular cigarettes. Using thromboelastography (TEG) degree platelet-fibrin interaction measured. In additional experiments, abciximab (20 microg/mL) added samples (n=27) reduce effects platelet function...
Atrial fibrillation (AF) is the most common cardiac dysrhythmia associated with significant morbidity and mortality. Several small studies have reported that low serum total testosterone (TT) levels were a higher incidence of AF. In contrast, it also anabolic steroid use an increase in risk To date, no study has explored effect normalization on new AF after replacement therapy (TRT) patients testosterone.Using data from Veterans Administrations Corporate Data Warehouse, we identified...
Women with chronic coronary disease are generally older than men and have more comorbidities but less atherosclerosis. We explored sex differences in revascularization, guideline-directed medical therapy, outcomes among patients ischemia on stress testing, without invasive management.
The purpose of this study was to determine the role nitric oxide and poly(ADP-ribose) synthase on impaired mitochondrial function in septic shock.Human umbilical vein endothelial cells were incubated with serum from ten healthy controls, 20 patients shock, seven critically ill who not septic. experiment repeated after pretreatment 3-aminobenzamide, a inhibitor, or N(G)-methyl-L-arginine, nonspecific inhibitor.Mitochondrial respiration measured using modified MTT...
Background— Data about the effects of smoking on thrombo-hemostatic factors (tissue factor [TF] and tissue pathway inhibitor [TFPI-1]) are limited fibrinolytic plasminogen activator [t-PA] inhibitor-1 [PAI-1]) debatable. The present study investigated smoking-related, endothelial cell (EC)–specific responses for these their relation to nitric oxide (NO) production in vitro. Methods Results— Serum from 8 nonsmokers 15 smokers were incubated with confluent (≈85%) human umbilical vein cells...
Abstract Objectives To assess the prognostic significance of high vs. low grade coronary artery ectasia (CAE) and impact antithrombotic or anticoagulant therapy on adverse cardiac outcomes. Background There is paucity knowledge angiographic characteristics in CAE that Methods results In this retrospective study, we reviewed angiograms medical records all cases confirmed (2001–2011). Extent was categorized using Markis classification. Types 1 2 were as high‐grade types 3 4 low‐grade CAE....
This brief report describes a case of transient left ventricular dysfunction in 42-year-old woman associated with methamphetamine abuse. Transient (stress-induced) has been described previously, usually postmenopausal women following emotional stress and also severe medical illness. is the first reported
ABSTRACT-We examined the mechanisms and adhesive molecules mediating platelet-neutrophil adhesion in patients with septic shock. Neutrophils, platelets, platelet poor plasma (NPPP) were isolated from 12 normal volunteers. Platelets neutrophils stimulated (SPPP) removed Cell was assessed by filtration through 5-microm pore filters flow cytometry. Blocking monoclonal antibodies used against neutrophil surface receptors glycoprotein complex IIb/IIla, P-selectin, ICAM-2, CD11a, CD11b, CD18. The...