A5018455558- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Oral Health Pathology and Treatment
- Esophageal Cancer Research and Treatment
- Circular RNAs in diseases
- RNA and protein synthesis mechanisms
- Ferroptosis and cancer prognosis
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- Skin Protection and Aging
- RNA Research and Splicing
- Genetic factors in colorectal cancer
- Ubiquitin and proteasome pathways
- Viral-associated cancers and disorders
- Moyamoya disease diagnosis and treatment
- Leptospirosis research and findings
- Colorectal Cancer Treatments and Studies
- Indoor Air Quality and Microbial Exposure
Mitchell Institute
2025
Texas A&M University
2025
Institute of Bioinformatics
2016-2024
Sardar Patel University
2022-2024
Einstein Medical Center Philadelphia
2024
Penn State Milton S. Hershey Medical Center
2024
Amrita Vishwa Vidyapeetham
2016-2023
Chemnitz University of Technology
2023
Institute of Bioinformatics and Applied Biotechnology
2021
Biotech Park
2021
Blockade of the programmed death 1 (PD-1) pathway has emerged as a novel therapy for cancer. Therefore, development biomarkers response prediction, such PD-ligand (PD-L1) expression by immunohistochemistry, may help to stratify patients. Solid tumors with CD8 T-cell rich tumor microenvironment have been implicated be associated increased PD-L1 expression. We hypothesized that gastric cancers Epstein-Barr virus infection (EBV+) or microsatellite instability (MSI), both which are known harbor...
Background Biliary tract cancers are rare, aggressive neoplasms. Most patients present with advanced/unresectable or metastatic disease at diagnosis, and no second‐line regimen has demonstrated clinical benefit. This was a phase 2 study evaluating the efficacy safety of regorafenib in who had after receiving standard therapy. Methods In this single arm‐study, biliary cancer failed least 1 line systemic chemotherapy received once daily on schedule 21‐days on/7‐days off 28‐day cycle. Patients...
Complementing genome sequence with deep transcriptome and proteome data could enable more accurate assembly annotation of newly sequenced genomes. Here, we provide a proof-of-concept an integrated approach for analysis the Anopheles stephensi, which is one most important vectors malaria parasite. To achieve broad coverage genes, carried out sequencing profiling multiple anatomically distinct sites. Based on transcriptomic alone, identified corrected 535 events incomplete involving 1196...
Breast cancer is the most common malignancy among women, with highest incidence rate worldwide. Dysregulation of long noncoding RNAs during preliminary stages breast carcinogenesis poorly understood. In this study, we performed RNA sequencing to identify expression profiles associated early-stage cancer. was on six invasive ductal carcinoma (IDC) tissues along paired normal tissue samples, seven in situ tissues, and five apparently tissues. We identified 375 differentially expressed lncRNAs...
To conduct a retrospective data collection on prevalence of functional food lentinan as its role in anti-cancer therapies and management carcinomas. The methodical review was carried out various indexed databases Scopus, Web sciences Pubmed, addition to the Google Scholar database. work focuses observational studies like anti-tumour, cytotoxic immunomodulating lentinan. World Health Organisation (WHO) classifies cancer second leading cause death worldwide, approximately 1 6 deaths occurring...
Abstract Contemporary approaches for developing interventions and assessing pre-clinical cardiovascular risk frequently utilize animal in vitro models. However, these models currently lack normal species-specific reference ranges similar to what exists humans. The genetically diverse Collaborative Cross (CC) population that human genetic heterogenetiety was characterized develop mouse-specific cardiac Mus muscuslus , the most commonly used pre-clincial model. Heart function analyzed males...
Purpose Carboxyamidotriazole orotate (CTO) is a novel oral inhibitor of non-voltage-dependent calcium channels with modulatory effects in multiple cell-signaling pathways and synergistic temozolomide (TMZ) glioblastoma (GBM) models. We conducted phase IB study combining CTO two standard TMZ schedules GBM. Methods In cohort 1, patients recurrent anaplastic gliomas or GBM received escalating doses (219 to 812.5 mg/m2 once daily 600 mg fixed once-daily dose) combined (150 5 days during each...
Abstract Epstein-Barr virus (EBV) oncoprotein EBNA3C is indispensable for primary B-cell transformation and maintenance of lymphoblastoid cells outgrowth. usurps two putative cellular pathways—cell-cycle apoptosis, essentially through modulating ubiquitin-mediated protein-degradation or gene transcription. In cancer cells, these pathways are interconnected with autophagy,—a survival-promoting catabolic network in which cytoplasmic material including mis/un-folded protein aggregates damaged...
Carcinogenic effect of tobacco in oral cancer is through chewing and/or smoking. Significant differences exist development between users and non-users. However, molecular alterations induced by different forms are yet to be fully elucidated. We developed cellular models chronic exposure cigarette smoke using immortalized keratinocytes. Chronic resulted increased cell scattering invasiveness miRNA sequencing Illumina HiSeq 2500 the identification 10 significantly dysregulated miRNAs (4 fold;...
Esophageal squamous cell carcinoma (ESCC) is the most common histological subtype of esophageal cancer in India. Cigarette smoking and chewing tobacco are known risk factors associated with ESCC. However, genomic alterations ESCC India not well characterized. In this study, we carried out exome sequencing to characterize mutational landscape tumors from subjects a varied history usage. The whole sequence analysis an Indian cohort revealed several genes that were mutated or had copy number...
Abstract Breast cancer is a major cause of cancer‐related death in women worldwide. Non‐coding RNAs are potential resource to be used as an early diagnostic biomarker for breast cancer. Circular recently identified group non‐coding RNA with significant role disease development utility diagnosis/prognosis In this study, we 26 differentially expressed circular associated early‐stage sequencing and two circRNA detection tools (find_circ DCC) were understand the expression signature We...
Male infertility poses a growing challenge to the healthcare system, with its prevalence on rise. Unhealthy lifestyle, food, and addictions such as smoking, alcoholism, etc accelerate occurrence. While several approaches are being investigated prevent treat this condition, each therapeutic approach has drawbacks. Traditional medications continue play crucial role in system. In recent years, there been shift towards determining efficacy of phytochemicals (or, herbal drugs) remedies. To...
Skin acts as a protective barrier against direct contact with pollutants but inhalation and systemic exposure have indirect effect on keratinocytes. Exposure to diesel exhaust has been linked increased oxidative stress.To investigate global proteomic alterations in particulate extract (DPE)/its vapor exposed skin keratinocytes.We employed Tandem Mass Tag (TMT)-based proteomics study of DPE/DPE primary observed an expression stress response protein NRF2, upon chronic keratinocytes DPE/its...
Tobacco in its smoke and smokeless form are major risk factors for esophageal squamous cell carcinoma (ESCC). However, molecular alterations associated with tobacco exposure poorly understood. In the Indian subcontinent, is predominantly consumed chewing form. An understanding of vital identifying markers potential targets. We developed an vitro cellular model by exposing non-transformed epithelial cells to over eight-month period. Chronic led increase proliferation, invasive ability...
Cigarette smoking has been associated with multiple negative effects on human skin. Long-term physiological of cigarette smoke are through chronic and not acute exposure. Molecular alterations due to exposure remain unclear. Primary skin keratinocytes chronically exposed condensate (CSC) showed a decreased wound-healing capacity an increased expression NRF2 MMP9. Using quantitative proteomics, we identified 4728 proteins, which 105 proteins were overexpressed (≥2-fold) 41 downregulated...
Oral squamous cell carcinoma (OSCC) is a common cancer of the oral cavity in India. Cigarette smoking and chewing tobacco are known risk factors associated with OSCC. However, genomic alterations OSCC varied consumption history not well-characterized. In this study, we carried out whole-exome sequencing to characterize mutational landscape tumors from subjects different habits. We identified several frequently mutated genes, including TP53 , NOTCH1 CASP8 RYR2 LRP2 CDKN2A ATM . HRAS exhibited...
Chronic exposure to cigarette smoke markedly increases the risk for lung cancer. Regulation of gene expression at post-transcriptional level by miRNAs influences a variety cancer-related interactomes. Yet, relatively little is known on effects long-term miRNA and regulation. NCI-H292 (H292) cell line sensitive with mucoepidermoid characteristics in culture. We report, this study, original observations (12 months) H292 line, using microarray-based profiling, stable isotopic labeling amino...
Transcription factors are commonly deregulated in various cancers. Here, we evaluated role of ELF3 pathogenesis bladder carcinoma (BCa).We confirmed expression pattern BCa cell lines using western blot; and different grades tumors Immunohistochemistry. Cell invasion assay was employed to demonstrate potential EMT.ELF3 showed selective low-grade tumor tissues. Overexpression mesenchymal line UMUC3 resulted reduced decreased markers. We observed association low with increased risk overall poor...
Gallbladder cancer (GBC) is a common malignancy of biliary tract cancers and its incidence has been rising rapidly worldwide. The prognosis for this disease dismal as most the symptoms are non-specific leading to definitive diagnosis only at late stage. Loss DKK3 gene associated with possible tumor suppressor role in human cancers. regulation GBC have not studied. We found that expression levels were low patients cell lines. Treatment lines demethylating agent 5-Aza- 2'-deoxycytidine...
Tobacco usage is a known risk factor associated with development of oral cancer. It mainly consumed in two different forms (smoking and chewing) that vary their composition methods intake. Despite being the leading cause cancer, molecular alterations induced by tobacco are poorly understood. We therefore sought to investigate adverse effects cigarette smoke/chewing exposure keratinocytes (OKF6/TERT1). OKF6/TERT1 cells acquired oncogenic phenotype after treating for period 8 months. employed...
Malaria is one of the most debilitating mosquito-borne diseases with high global health burdens. While much research on malaria and focused Africa, Southeast Asia accounts for a sizable portion burden malaria. Moreover, about 50% Asian incidence deaths have been from India. A promising development in this context that completion genome sequence Anopheles stephensi, major vector Asia, offers new opportunities innovation, including progress deciphering vectorial ability mosquito species at...
The frequency of Candida infections is currently rising, and thus adversely impacting global health. situation exacerbated by azole resistance developed fungal pathogens. tropicalis an opportunistic pathogen that causes candidiasis, for example, in immune-compromised individuals, cancer patients, those who undergo organ transplantation. It a member the non-albicans group are known to be azole-resistant, frequently seen individuals being treated cancers, HIV-infection, underwent bone marrow...
Abstract The Triton X‐114‐based solubilization and temperature‐dependent phase separation of proteins is used for subcellular fractionation where, aqueous, detergent, pellet fractions represents cytoplasmic, outer membrane (OM), inner proteins, respectively. Mass spectrometry‐based proteomic analysis X‐114 Leptospira interrogans identified 2957 unique distributed across the fractions. results are compared with bioinformatics predictions on their localization pathogenic nature. Analysis...
Abstract Epidermal growth factor receptor (EGFR) targeted therapies have shown limited efficacy in head and neck squamous cell carcinoma (HNSCC) patients despite its overexpression. Identifying molecular mechanisms associated with acquired resistance to EGFR-TKIs such as erlotinib remains an unmet need a therapeutic challenge. In this study, we employed integrated multi-omics approach delineate by carrying out whole exome sequencing, quantitative proteomic phosphoproteomic profiling. We...