A5003680467- Insect symbiosis and bacterial influences
- Systemic Lupus Erythematosus Research
- Mosquito-borne diseases and control
- Immunodeficiency and Autoimmune Disorders
- Inflammatory Myopathies and Dermatomyositis
- Genomics and Phylogenetic Studies
- Advanced Proteomics Techniques and Applications
- Parasitic Diseases Research and Treatment
- RNA modifications and cancer
- Plant tissue culture and regeneration
- Cardiac Structural Anomalies and Repair
- Machine Learning in Bioinformatics
- Renal Diseases and Glomerulopathies
- Systemic Sclerosis and Related Diseases
- Malaria Research and Control
- Vascular Tumors and Angiosarcomas
- Invertebrate Immune Response Mechanisms
- Insect Resistance and Genetics
- Bioinformatics and Genomic Networks
- interferon and immune responses
- Platelet Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Gene Regulatory Network Analysis
- Skin Diseases and Diabetes
- Lymphoma Diagnosis and Treatment
University of Pennsylvania
2022
Institute of Bioinformatics
2009-2016
Amrita Vishwa Vidyapeetham
2011-2014
Sanjay Gandhi Post Graduate Institute of Medical Sciences
1998-2014
West Suffolk Hospital
2012
Complementing genome sequence with deep transcriptome and proteome data could enable more accurate assembly annotation of newly sequenced genomes. Here, we provide a proof-of-concept an integrated approach for analysis the Anopheles stephensi, which is one most important vectors malaria parasite. To achieve broad coverage genes, carried out sequencing profiling multiple anatomically distinct sites. Based on transcriptomic alone, identified corrected 535 events incomplete involving 1196...
Accurate annotation of protein-coding genes is one the primary tasks upon completion whole genome sequencing any organism. In this study, we used an integrated transcriptomic and proteomic strategy to validate improve existing zebrafish annotation. We undertook high-resolution mass-spectrometry-based profiling 10 adult organs, fish body, two developmental stages (SAT line), in addition six organs. More than 7,000 proteins were identified from analyses, ∼69,000 high-confidence transcripts...
Although the targets of most miRNAs have not been experimentally identified, microRNAs (miRNAs) begun to be extensively characterized in physiological, developmental and disease-related contexts recent years. Thus far, mainly computational approaches employed predict potential for large majority miRNAs. exert a major influence on efficiency translation their animals, studies describing experimental identification miRNA target genes are based detection altered mRNA levels. miR-143 is involved...
Anopheles gambiae is a major mosquito vector responsible for malaria transmission, whose genome sequence was reported in 2002. Genome annotation continuing effort, and many of the approximately 13,000 genes listed VectorBase are predictions that have still not been validated by any other method. To identify protein-coding An. based on its genomic sequence, we carried out deep proteomic analysis using high-resolution Fourier transform mass spectrometry both precursor fragment ions. Based...
Gastric cancer is the second leading cause of death worldwide, both in men and women. A genomewide gene expression analysis was carried out to identify differentially expressed genes gastric adenocarcinoma tissues as compared adjacent normal tissues. We used Agilent's whole human genome oligonucleotide microarray platform representing ~41,000 carry analysis. Two-color employed directly compare between tumor Through this approach, we identified several previously known candidate along with a...
The aim of this study was to examine whether the clinical features antiphospholipid antibody syndrome are associated with anti-cardiolipin and anti-beta2 glycoprotein I antibodies in Indian patients SLE. Seventy-six (71 females), who fulfilled 1982 ACR criteria for SLE, were prospectively studied (APS), their sera analysed presence IgG/IgM/IgA (aCL) by an in-house ELISA and, 65 them, IgG (anti-beta2 GPI) a commercial kit. Thirty-nine (51%) positive aCL, all which either alone (79.6%) or...
Follicle stimulating hormone (FSH) is an important responsible for growth, maturation and function of the human reproductive system. FSH regulates synthesis steroid hormones such as estrogen progesterone, proliferation follicles in ovary spermatogenesis testes. a glycoprotein heterodimer that binds acts through receptor, G-protein coupled receptor. Although online pathway repositories provide information about receptor mediated signal transduction, signaling events initiated specifically by...
Anopheles gambiae has a well-adapted system for host localization, feeding, and mating behavior, which are all governed by neuronal processes in the brain. However, there no published reports characterizing brain proteome to elucidate signaling mechanisms vector. To this end, large-scale mapping of An. was carried out using high resolution tandem mass spectrometry, revealing repertoire >1800 proteins, 15% could not be assigned any function. A large proportion identified proteins were...
Canine heartworm is a widespread and potentially fatal mosquito-borne disease caused by infections with the parasitic nematode, Dirofilaria immitis. We have previously shown that systemic activation of Toll immune pathway via silencing negative regulator Cactus in Aedes aegypti blocks parasite development Malpighian tubules (MT), mosquito renal organ. However, it was not established whether MT were directly responding to or alternatively upregulated proteins other changes hemolymph driven...
Les myopathies inflammatoires sont un groupe de maladies systémiques auto-immunes qui comprennent les polymyosites, dermatomyosites et à inclusion. Pour faciliter le diagnostic, critères classiques fondés sur des cliniques. En complément, depuis une quinzaine d'années autoanticorps caractérisant certaines formes ont été identifiés. spécifiques ces myosites douzaine spécificités que l'on classe en fonction la répartition cellulaire l'autoantigène ; plus caractéristiques ceux dirigés contre...
Abstract Background Canine heartworm is a widespread and potentially fatal mosquito-borne disease caused by infections with the parasitic nematode, Dirofilaria immitis . We have previously shown that systemic activation of Toll immune pathway via silencing negative regulator Cactus in Aedes aegypti blocks parasite development Malpighian tubules, mosquito renal organ. However, it was not established whether tubules were directly responding to or alternatively upregulated proteins other...