A5085743942- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced NMR Techniques and Applications
- Medical Imaging Techniques and Applications
- Nuclear Physics and Applications
- MRI in cancer diagnosis
- Neuroscience and Neuropharmacology Research
- Wireless Sensor Networks for Data Analysis
- Bipolar Disorder and Treatment
- Integrated Energy Systems Optimization
- Anesthesia and Neurotoxicity Research
- Alzheimer's disease research and treatments
- Lanthanide and Transition Metal Complexes
- Neurological disorders and treatments
- Smart Grid Energy Management
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2019-2023
Frédéric Joliot Institute for Life Sciences
2023
CEA Paris-Saclay
2019-2023
Université Paris-Saclay
2019-2022
Centre National de la Recherche Scientifique
2021-2022
General Electric (Spain)
2020
Purpose The SNR at the center of a spherical phantom known electrical properties was measured in quasi‐identical experimental conditions as function magnetic field strength between 3 T and 11.7 T. Methods water saline with gradient‐recalled echo sequence. Measurements were performed NeuroSpin 3, 7, then shipped to Maastricht University Minnesota for additional data points 9.4, 10.5 Experiments carried out exact same type birdcage volume coil (except T, where similar used) attempt isolating...
BackgroundLithium (Li) is a first-line treatment for bipolar disorder (BD). To study its cerebral distribution and association with plasma concentrations, we used 7Li magnetic resonance imaging at 7T in euthymic patients BD treated Li carbonate least 2 years.MethodsThree-dimensional scans (N = 21) were acquired an ultra-short echo-time sequence using non-Cartesian k-space sampling scheme. Lithium concentrations ([Li]) estimated phantom replacement approach accounting differential T1 T2...
Abstract The pathophysiological processes underlying the development and progression of Alzheimer's disease (AD) on neuronal level are still unclear. Previous research has hinted at metabolic energy deficits altered sodium homeostasis with impaired function as a potential marker relevant for neurotransmission in AD. Using ( 23 Na) magnetic resonance (MR) imaging an ultra‐high‐field 7 Tesla MR scanner, we found increased cerebral tissue concentration (TSC) 17 biomarker‐defined AD patients...
Application of MRI in clinical routine mainly addresses structural alterations. However, pathological changes at a cellular level are expected to precede the occurrence brain atrophy clusters and symptoms. In this context, 23Na-MRI examines sodium as potential metabolic parameter. Recently, we have shown that ultra-high-field (7 T) was able detect increased tissue concentration (TSC) Alzheimer's disease (AD). work, aimed assessing AD-pathology with larger cohort on 3T MR scanner.We used...
After more than 20 years of research and development, the 11.7T Iseult MRI scanner is in last stage its commissioning. However, authorization Human examination at this unprecedented magnetic field strength still pending. In context, examinations healthy anaesthetized non-human primates are being carried out to check on absence acute physiological effects following exposure gain some insights into opportunities challenges ahead.
Abstract Background [18F]‐2‐fluoro‐2‐deoxy‐D‐glucose (FDG) positron emission tomography (PET) is applied to delineate cerebral glucose metabolic patterns in Alzheimer’s disease (AD). Sodium MR imaging ( 23 Na‐MRI) can reveal alterations tissue sodium concentration (TSC) the brain, potentially reflecting mitochondrial dysfunction and impaired cellular energy state. This initial study aims at investigating disease‐specific topographical associations between metabolism assessed via FDG‐PET...
Quantitative 23 Na MRI provides useful information about brain tissue homeostasis. Most sequences use deterministic non-Cartesian 3D trajectories such as TPI. However, stochastic strategies SPARKLING could improve the coverage of k-space. This study evaluates advantages versus From in vivo datasets at 7T, we determined that undersampled acquisitions outperform TPI for (8 mm) 3 resolution with a birdcage coil or (4 32-channel coil. Through extrapolation these results, predict...